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Sesn3
Gene Detail
Symbol

Name
ID
Sesn3
sestrin 3
MGI:1922997
Synonyms
5630400E15Rik, MGC:7182, SEST3
Feature Type
protein coding gene
Genetic Map
Chromosome 9
3.89 cM, cytoband A3
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr9:14276301-14326138 bp, + strand
From VEGA annotation of GRCm38

  49838 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:14386  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: SESN3
Gene Tree: Sesn3

Human
homologs
SESN3, sestrin 3
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 143686
neXtProt AC: NX_P58005

Human Synonyms: SEST3

Human Chr (Location): 11q21; chr11:95165513-95232541 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Gene trapped(1) Targeted(1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
When fed a high fad diet, mice homozygous for a gene trap allele exhibit impaired glucose tolerance, insulin resistance, reduced hepatic glucose production, impaired adipocyte glucose uptakem increased hepatic steatosis, and decreased mitochondria in the liver.
 
Interactions
Sesn3 interacts with 87 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (6 annotations)
Process glucose homeostasis, regulation of protein kinase B signaling, ...
Component nucleus
Function molecular_function
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (2)    Tissues (2)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 2
cDNA source data(9)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase sesn3 ; ZFIN sesn3    NEW 
Molecular
reagents
All nucleic(9) cDNA(9)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000021054 (Evidence)
Ensembl Gene Model ENSMUSG00000032009 (Evidence)
Entrez Gene 75747 (Evidence)
DFCI TC1583018, TC1582425, TC1606228, TC1622822, TC1630753, TC1714892
DoTS DT.91592424, DT.480733, DT.101261717, DT.101347264, DT.101339864
NIA Mouse Gene Index U010065, U010064, U214762
Consensus CDS Project CCDS22820.1
International Mouse Phenotyping Consortium Status Sesn3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021054 VEGA Gene Model | MGI Sequence Detail 49838 C57BL/6J ±  kb
transcript OTTMUST00000049804 VEGA | MGI Sequence Detail 2162 Not Applicable 
polypeptide OTTMUSP00000023133 VEGA | MGI Sequence Detail 492 Not Applicable 

For the selected sequences
All sequences(41) RefSeq(2) UniProt(4)
Polymorphisms
SNPs within 2kb(247 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006730 PA26 p53-induced protein (sestrin)
Protein Ontology PR:000014716 sestrin-3
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:204895 Lee JH, et al., Sestrins orchestrate cellular metabolism to attenuate aging. Cell Metab. 2013 Dec 3;18(6):792-801
All references(34)
Other
accession IDs
MGI:1933128

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory