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Sesn3
Gene Detail
Symbol

Name
ID
Sesn3
sestrin 3
MGI:1922997
Synonyms
5630400E15Rik, MGC:7182, SEST3
Feature Type
protein coding gene
Genetic Map
Chromosome 9
3.89 cM, cytoband A3
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr9:14276301-14326138 bp, + strand
From VEGA annotation of GRCm38

  49838 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:14386  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Sesn3

Human
homologs
Human Homolog SESN3, sestrin 3
NCBI Gene ID 143686
neXtProt AC  NX_P58005
Human Synonyms  SEST3
Human Chr (Location)  11q21; chr11:95165513-95232541 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Gene trapped(1) Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
 
When fed a high fad diet, mice homozygous for a gene trap allele exhibit impaired glucose tolerance, insulin resistance, reduced hepatic glucose production, impaired adipocyte glucose uptakem increased hepatic steatosis, and decreased mitochondria in the liver.
 
Interactions
Sesn3 interacts with 87 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (6 annotations)
Process glucose homeostasis, regulation of protein kinase B signaling, ...
Component nucleus
Function molecular_function
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (2)    Tissues (2)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 2
cDNA source data(9)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(9) cDNA(9)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000021054 (Evidence)
Ensembl Gene ModelENSMUSG00000032009 (Evidence)
Entrez Gene75747 (Evidence)
DFCITC1582425, TC1583018, TC1606228, TC1622822, TC1630753, TC1714892
DoTSDT.101261717, DT.101339864, DT.101347264, DT.480733, DT.91592424
NIA Mouse Gene IndexU010064, U010065, U214762
Consensus CDS ProjectCCDS22820.1
International Mouse Knockout Project StatusSesn3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021054 VEGA Gene Model | MGI Sequence Detail 49838 C57BL/6J ±  kb
transcript OTTMUST00000049804 VEGA | MGI Sequence Detail 2162 Not Applicable 
polypeptide OTTMUSP00000023133 VEGA | MGI Sequence Detail 492 Not Applicable 

For the selected sequences
All sequences(41) RefSeq(2) UniProt(4)
Polymorphisms
SNPs within 2kb(247 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006730 PA26 p53-induced protein (sestrin)
Protein Ontology PR:000014716 sestrin-3
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:204895 Lee JH, et al., Sestrins orchestrate cellular metabolism to attenuate aging. Cell Metab. 2013 Dec 3;18(6):792-801
All references(36)
Other
accession IDs
MGI:1933128

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory