About   Help   FAQ
Bcl2l12 Gene Detail
Summary
  • Symbol
    Bcl2l12
  • Name
    BCL2-like 12 (proline rich)
  • Synonyms
    2810475P17Rik, 5430429M05Rik, Bcl2-L12, Bcl-L12
  • Feature Type
    protein coding gene
  • IDs
    MGI:1922986
    NCBI Gene: 75736
  • Gene Overview
    MyGene.info: BCL2L12
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:44991222-44997638 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 29.07 cM, cytoband B2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    79 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1922986
protein coding gene Chr7:44991222-44998712 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032191
protein coding gene Chr7:45215539-45222029 (-)
A/J MGP_AJ_G0032170
protein coding gene Chr7:44359031-44365401 (-)
AKR/J MGP_AKRJ_G0032106
protein coding gene Chr7:45585163-45591507 (-)
BALB/cJ MGP_BALBcJ_G0032182
protein coding gene Chr7:44357150-44363515 (-)
C3H/HeJ MGP_C3HHeJ_G0031898
protein coding gene Chr7:46086534-46093726 (-)
C57BL/6NJ MGP_C57BL6NJ_G0032674
protein coding gene Chr7:47476785-47483142 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029688
protein coding gene Chr7:46926295-46932665 (-)
CAST/EiJ MGP_CASTEiJ_G0031226
protein coding gene Chr7:37456877-37463556 (-)
CBA/J MGP_CBAJ_G0031862
protein coding gene Chr7:49039470-49045857 (-)
DBA/2J MGP_DBA2J_G0032020
protein coding gene Chr7:44030388-44036916 (-)
FVB/NJ MGP_FVBNJ_G0031971
protein coding gene Chr7:43807132-43813788 (-)
LP/J MGP_LPJ_G0032098
protein coding gene Chr7:45892012-45898394 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032008
protein coding gene Chr7:47760592-47767772 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0032690
protein coding gene Chr7:44805018-44811369 (-)
PWK/PhJ MGP_PWKPhJ_G0030949
protein coding gene Chr7:37394912-37401327 (-)
SPRET/EiJ MGP_SPRETEiJ_G0030786
protein coding gene Chr7:32812506-32818858 (-)
WSB/EiJ MGP_WSBEiJ_G0031343
protein coding gene Chr7:45281883-45288173 (-)



Homology
more
  • Human Ortholog
    BCL2L12, BCL2 like 12
  • Vertebrate Orthologs
    6
  • Human Ortholog
    BCL2L12, BCL2 like 12
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 83596
    neXtProt AC: NX_Q9HB09
    UniProt: Q9HB09

  • Chr Location
    19q13.33; chr19:49665072-49673916 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    178 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 75736 NCBI Gene Model | MGI Sequence Detail 6417 C57BL/6J ±  kb
    transcript NM_029410 RefSeq | MGI Sequence Detail 1090 C57BL/6  
    polypeptide NP_083686 RefSeq | MGI Sequence Detail 255 C57BL/6  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    Molecular
    Reagents
    less
    • All nucleic 7
      cDNA 7

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1920050
    References
    more
    • Summaries
      All 199
      Developmental Gene Expression 1
      Gene Ontology 4
      Phenotypes 178
    • Earliest
      J:98127 Sato M, et al., Distinct and essential roles of transcription factors IRF-3 and IRF-7 in response to viruses for IFN-alpha/beta gene induction. Immunity. 2000 Oct;13(4):539-48
    • Latest
      J:275220 Huai W, et al., KAT8 selectively inhibits antiviral immunity by acetylating IRF3. J Exp Med. 2019 Apr 1;216(4):772-785

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    10/08/2019
    MGI 6.14
    The Jackson Laboratory