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Pank1 Gene Detail
Summary
  • Symbol
    Pank1
  • Name
    pantothenate kinase 1
  • Synonyms
    4632412I06Rik, 5430426F23Rik, Pank1, Pank1a, Pank1b
  • Feature Type
    protein coding gene
  • IDs
    MGI:1922985
    NCBI Gene: 75735
  • Gene Overview
    MyGene.info: PANK1
  • Alliance
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:34810894-34879455 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 19, 29.79 cM, cytoband G1-G3
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    475 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1922985
protein coding gene Chr19:34806935-34879593 (-)
129S1/SvImJ MGP_129S1SvImJ_G0025066
protein coding gene Chr19:33585877-33657573 (-)
A/J MGP_AJ_G0025042
protein coding gene Chr19:31953395-32022596 (-)
AKR/J MGP_AKRJ_G0025010
protein coding gene Chr19:33061948-33132180 (-)
BALB/cJ MGP_BALBcJ_G0025040
protein coding gene Chr19:32074757-32144012 (-)
C3H/HeJ MGP_C3HHeJ_G0024799
protein coding gene Chr19:33136249-33209915 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025481
protein coding gene Chr19:34586387-34657724 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022899
protein coding gene Chr19:31368718-31435776 (-)
CAST/EiJ MGP_CASTEiJ_G0024266
protein coding gene Chr19:32888140-32961131 (-)
CBA/J MGP_CBAJ_G0024776
protein coding gene Chr19:36176862-36267368 (-)
DBA/2J MGP_DBA2J_G0024908
protein coding gene Chr19:31854603-31923009 (-)
FVB/NJ MGP_FVBNJ_G0024869
protein coding gene Chr19:31682520-31749869 (-)
LP/J MGP_LPJ_G0024994
protein coding gene Chr19:33699063-33771381 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024900
protein coding gene Chr19:35963021-36035251 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025539
protein coding gene Chr19:33137641-33205701 (-)
PWK/PhJ MGP_PWKPhJ_G0024018
protein coding gene Chr19:31673056-31742995 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023818
protein coding gene Chr19:32001106-32075475 (-)
WSB/EiJ MGP_WSBEiJ_G0024333
protein coding gene Chr19:33211627-33281418 (-)



Homology
more
  • Human Ortholog
    PANK1, pantothenate kinase 1
  • Vertebrate Orthologs
    8
  • Human Ortholog
    PANK1, pantothenate kinase 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    PANK
  • Links
    NCBI Gene ID: 53354
    neXtProt AC: NX_Q8TE04
    UniProt: Q8TE04

  • Chr Location
    10q23.31; chr10:89579497-89645572 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from 1 allele in 2 genetic backgrounds
    19 phenotypes from multigenic genotypes
    3 images
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mutant has increased body weight, polyphagia, decreased serum triglyceride and glucose levels after fasting.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000033610 Ensembl Gene Model | MGI Sequence Detail 68562 C57BL/6J ±  kb
    transcript ENSMUST00000036584 Ensembl | MGI Sequence Detail 3460 Not Applicable  
    polypeptide ENSMUSP00000043562 Ensembl | MGI Sequence Detail 548 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 12
      Genomic 1
      cDNA 11

      Microarray probesets 10
    Other
    Accession IDs
    less
    MGI:1925512
    References
    more
    • Summaries
      All 41
      Developmental Gene Expression 4
      Gene Ontology 10
      Phenotypes 8
    • Earliest
      J:74934 Rock CO, et al., Pantothenate kinase regulation of the intracellular concentration of coenzyme A. J Biol Chem. 2000 Jan 14;275(2):1377-83
    • Latest
      J:228074 Zano SP, et al., Correction of a genetic deficiency in pantothenate kinase 1 using phosphopantothenate replacement therapy. Mol Genet Metab. 2015 Dec;116(4):281-8

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory