About   Help   FAQ
Mff Gene Detail
Summary
  • Symbol
    Mff
  • Name
    mitochondrial fission factor
  • Synonyms
    5230400G24Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1922984
    NCBI Gene: 75734
  • Gene Overview
    MyGene.info: MFF
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr1:82724890-82752394 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      27505 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 42.45 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    MFF, mitochondrial fission factor
  • Vertebrate Orthologs
    6
  • Human Ortholog
    MFF, mitochondrial fission factor
    Orthology source: HGNC
  • Synonyms
    C2orf33, EMPF2, GL004
  • Links
    NCBI Gene ID: 56947
    neXtProt AC: NX_Q9GZY8
    UniProt: Q9GZY8

  • Chr Location
    2q36.3; chr2:227325151-227357836 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous knockout reduces mitochondrial hyperfusion-induced apoptotic cell death of endothelial cells of cardiac microvessels after induced ischemia/reperfusion injury.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034764 VEGA Gene Model | MGI Sequence Detail 27505 C57BL/6J ±  kb
transcript OTTMUST00000088345 VEGA | MGI Sequence Detail 2087 Not Applicable  
polypeptide OTTMUSP00000048133 VEGA | MGI Sequence Detail 316 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    284 from dbSNP Build 142
Protein
Information
less
  • UniProt
    9 Sequences
  • InterPro Domains
    IPR008518 FATE/Miff/Tango-11
Molecular
Reagents
less
  • All nucleic 8
    cDNA 8

    Microarray probesets 3
Other
Accession IDs
less
MGI:2138195
References
more
  • Summaries
    All 36
    Developmental Gene Expression 1
    Gene Ontology 6
    Phenotypes 10
  • Earliest
    J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
  • Latest
    J:255071 Zhou H, et al., Mff-Dependent Mitochondrial Fission Contributes to the Pathogenesis of Cardiac Microvasculature Ischemia/Reperfusion Injury via Induction of mROS-Mediated Cardiolipin Oxidation and HK2/VDAC1 Disassociation-Involved mPTP Opening. J Am Heart Assoc. 2017 Mar 13;6(3):None

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
06/05/2018
MGI 6.12
The Jackson Laboratory