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Mff Gene Detail
Summary
  • Symbol
    Mff
  • Name
    mitochondrial fission factor
  • Synonyms
    5230400G24Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1922984
    NCBI Gene: 75734
  • Gene Overview
    MyGene.info: MFF
Location & Maps
more
  • Sequence Map
    Chr1:82724890-82752394 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      27505 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 42.45 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    MFF, mitochondrial fission factor
  • Vertebrate Orthologs
    6
  • Human Ortholog
    MFF, mitochondrial fission factor
    Orthology source: HGNC
  • Synonyms
    C2orf33, GL004
  • Links
    NCBI Gene ID: 56947
    neXtProt AC: NX_Q9GZY8

  • Chr Location
    2q36.3; chr2:227325151-227357836 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotype references
  • All Mutations and Alleles
    8
  • Chemically induced (other)
    1
  • Gene trapped
    6
  • Radiation induced
    1
  • Genomic Mutations
    2 involving Mff
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034764 VEGA Gene Model | MGI Sequence Detail 27505 C57BL/6J ±  kb
transcript OTTMUST00000088345 VEGA | MGI Sequence Detail 2087 Not Applicable  
polypeptide OTTMUSP00000048133 VEGA | MGI Sequence Detail 316 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    284 from dbSNP Build 142
Protein
Information
less
  • UniProt
    7 Sequences
  • Protein Ontology
    PR:000010366 mitochondrial fission factor
  • InterPro Domains
    IPR008518 FATE/Miff/Tango-11
Molecular
Reagents
less
  • All nucleic 8
    cDNA 8

    Microarray probesets 3
Other
Accession IDs
less
MGI:2138195
References
more
  • Summaries
    All 28
    Developmental Gene Expression 1
    Gene Ontology 5
    Phenotypes 7
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:224310 Ishihara T, et al., Dynamics of mitochondrial DNA nucleoids regulated by mitochondrial fission is essential for maintenance of homogeneously active mitochondria during neonatal heart development. Mol Cell Biol. 2015 Jan;35(1):211-23

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory