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Mff Gene Detail
Summary
  • Symbol
    Mff
  • Name
    mitochondrial fission factor
  • Synonyms
    5230400G24Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1922984
    NCBI Gene: 75734
  • Gene Overview
    MyGene.info: MFF
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:82724890-82752390 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 42.45 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    284 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1922984
protein coding gene Chr1:82724890-82752394 (.)
129S1/SvImJ MGP_129S1SvImJ_G0016218
protein coding gene Chr1:83645968-83673497 (+)
A/J MGP_AJ_G0016201
protein coding gene Chr1:80677489-80705075 (+)
AKR/J MGP_AKRJ_G0016158
protein coding gene Chr1:82876266-82906291 (+)
BALB/cJ MGP_BALBcJ_G0016156
protein coding gene Chr1:80821250-80848755 (+)
C3H/HeJ MGP_C3HHeJ_G0015986
protein coding gene Chr1:83256963-83288094 (+)
C57BL/6NJ MGP_C57BL6NJ_G0016609
protein coding gene Chr1:86872469-86899970 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014329
protein coding gene Chr1:75899945-75927569 (+)
CAST/EiJ MGP_CASTEiJ_G0015572
protein coding gene Chr1:82677751-82705271 (+)
CBA/J MGP_CBAJ_G0015960
protein coding gene Chr1:89659957-89691893 (+)
DBA/2J MGP_DBA2J_G0016061
protein coding gene Chr1:79965227-79994756 (+)
FVB/NJ MGP_FVBNJ_G0016064
protein coding gene Chr1:79061224-79089136 (+)
LP/J MGP_LPJ_G0016134
protein coding gene Chr1:84761501-84789616 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016084
protein coding gene Chr1:93055657-93083160 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0016656
protein coding gene Chr1:83041620-83071083 (+)
PWK/PhJ MGP_PWKPhJ_G0015357
protein coding gene Chr1:79406769-79435535 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015135
protein coding gene Chr1:82240036-82267553 (+)
WSB/EiJ MGP_WSBEiJ_G0015632
protein coding gene Chr1:82842926-82870969 (+)



Homology
more
  • Human Ortholog
    MFF, mitochondrial fission factor
  • Vertebrate Orthologs
    6
  • Human Ortholog
    MFF, mitochondrial fission factor
    Orthology source: HGNC
  • Synonyms
    C2orf33, EMPF2, GL004
  • Links
    NCBI Gene ID: 56947
    neXtProt AC: NX_Q9GZY8
    UniProt: Q9GZY8

  • Chr Location
    2q36.3; chr2:227325151-227357836 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous knockout reduces mitochondrial hyperfusion-induced apoptotic cell death of endothelial cells of cardiac microvessels after induced ischemia/reperfusion injury.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 75734 NCBI Gene Model | MGI Sequence Detail 27501 C57BL/6J ±  kb
transcript NM_029409 RefSeq | MGI Sequence Detail 1908 C57BL/6  
polypeptide Q6PCP5 UniProt | EBI | MGI Sequence Detail 291 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 9
    Genomic 1
    cDNA 8

    Microarray probesets 3
Other
Accession IDs
less
MGI:2138195
References
more
  • Summaries
    All 36
    Developmental Gene Expression 1
    Gene Ontology 6
    Phenotypes 10
  • Earliest
    J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
  • Latest
    J:255071 Zhou H, et al., Mff-Dependent Mitochondrial Fission Contributes to the Pathogenesis of Cardiac Microvasculature Ischemia/Reperfusion Injury via Induction of mROS-Mediated Cardiolipin Oxidation and HK2/VDAC1 Disassociation-Involved mPTP Opening. J Am Heart Assoc. 2017 Mar 13;6(3)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory