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Amotl1 Gene Detail
Summary
  • Symbol
    Amotl1
  • Name
    angiomotin-like 1
  • Synonyms
    2310010G08Rik, 2310067L22Rik, 4932416D09Rik, JEAP
  • Feature Type
    protein coding gene
  • IDs
    MGI:1922973
    NCBI Gene: 75723
  • Gene Overview
    MyGene.info: AMOTL1
  • Alliance
  • Transcription Start Sites
    13 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:14541966-14645056 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 4.12 cM, cytoband A3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    818 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1922973
protein coding gene Chr9:14541966-14662960 (-)
129S1/SvImJ MGP_129S1SvImJ_G0034351
protein coding gene Chr9:11495700-11561783 (-)
A/J MGP_AJ_G0034329
protein coding gene Chr9:11447045-11513126 (-)
AKR/J MGP_AKRJ_G0034257
protein coding gene Chr9:11454209-11523976 (-)
BALB/cJ MGP_BALBcJ_G0034323
protein coding gene Chr9:11218749-11285233 (-)
C3H/HeJ MGP_C3HHeJ_G0034034
protein coding gene Chr9:11745132-11838923 (-)
C57BL/6NJ MGP_C57BL6NJ_G0034845
protein coding gene Chr9:11871910-11940772 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031783
protein coding gene Chr9:10735202-10805849 (-)
CAST/EiJ MGP_CASTEiJ_G0033361
protein coding gene Chr9:11577206-11646015 (-)
CBA/J MGP_CBAJ_G0034007
protein coding gene Chr9:12424311-12520522 (-)
DBA/2J MGP_DBA2J_G0034164
protein coding gene Chr9:11321507-11412161 (-)
FVB/NJ MGP_FVBNJ_G0034109
protein coding gene Chr9:10911468-10977917 (-)
LP/J MGP_LPJ_G0034250
protein coding gene Chr9:11585358-11658686 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0034153
protein coding gene Chr9:13482813-13551318 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0034864
protein coding gene Chr9:11479890-11550118 (-)
PWK/PhJ MGP_PWKPhJ_G0033067
protein coding gene Chr9:11377387-11448598 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032903
protein coding gene Chr9:11539916-11611168 (-)
WSB/EiJ MGP_WSBEiJ_G0033477
protein coding gene Chr9:11305887-11377952 (-)



Homology
more
  • Human Ortholog
    AMOTL1, angiomotin like 1
  • Vertebrate Orthologs
    8
  • Human Ortholog
    AMOTL1, angiomotin like 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    JEAP
  • Links
    NCBI Gene ID: 154810
    neXtProt AC: NX_Q8IY63
    UniProt: Q8IY63

  • Chr Location
    11q21; chr11:94706418-94876753 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000013076 Ensembl Gene Model | MGI Sequence Detail 103091 C57BL/6J ±  kb
transcript ENSMUST00000223132 Ensembl | MGI Sequence Detail 3046 Not Applicable  
polypeptide ENSMUSP00000152834 Ensembl | MGI Sequence Detail 1005 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 141
    cDNA 141

    Microarray probesets 6
Other
Accession IDs
less
MGI:1916817, MGI:1917651
References
more
  • Summaries
    All 40
    Developmental Gene Expression 3
    Gene Ontology 9
    Phenotypes 5
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:243807 Ragni CV, et al., Amotl1 mediates sequestration of the Hippo effector Yap1 downstream of Fat4 to restrict heart growth. Nat Commun. 2017 Feb 27;8:14582

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/27/2018
MGI 6.13
The Jackson Laboratory