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Cul5 Gene Detail
Summary
  • Symbol
    Cul5
  • Name
    cullin 5
  • Synonyms
    4921514I20Rik, 8430423K24Rik, C030032G03Rik, C330021I08Rik, VACM-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1922967
    NCBI Gene: 75717
  • Gene Overview
    MyGene.info: CUL5
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:53614582-53667507 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 29.12 cM, cytoband C
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    42 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1922967
protein coding gene Chr9:53614582-53670014 (-)
129S1/SvImJ MGP_129S1SvImJ_G0034814
protein coding gene Chr9:52647527-52709568 (-)
A/J MGP_AJ_G0034795
protein coding gene Chr9:50988531-51042775 (-)
AKR/J MGP_AKRJ_G0034723
protein coding gene Chr9:52091991-52151864 (-)
BALB/cJ MGP_BALBcJ_G0034787
protein coding gene Chr9:50740114-50794928 (-)
C3H/HeJ MGP_C3HHeJ_G0034497
protein coding gene Chr9:52572026-52628903 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035306
protein coding gene Chr9:54126635-54188194 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032219
protein coding gene Chr9:50397868-50443908 (-)
CAST/EiJ MGP_CASTEiJ_G0033819
protein coding gene Chr9:52578045-52637245 (-)
CBA/J MGP_CBAJ_G0034468
protein coding gene Chr9:55960201-56021339 (-)
DBA/2J MGP_DBA2J_G0034627
protein coding gene Chr9:50866627-50921431 (-)
FVB/NJ MGP_FVBNJ_G0034569
protein coding gene Chr9:50047552-50101232 (-)
LP/J MGP_LPJ_G0034709
protein coding gene Chr9:52948846-53004444 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0034612
protein coding gene Chr9:57550279-57607769 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035328
protein coding gene Chr9:52096104-52165501 (-)
PWK/PhJ MGP_PWKPhJ_G0033523
protein coding gene Chr9:50844263-50900652 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033359
protein coding gene Chr9:52395394-52450113 (-)
WSB/EiJ MGP_WSBEiJ_G0033931
protein coding gene Chr9:52093824-52151046 (-)



Homology
more
  • Human Ortholog
    CUL5, cullin 5
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CUL5, cullin 5
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CUL-5, VACM1, VACM-1
  • Links
    NCBI Gene ID: 8065
    neXtProt AC: NX_Q93034
    UniProt: Q93034

  • Chr Location
    11q22.3; chr11:108008682-108107766 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 2597
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: CUL5
  • Protein SuperFamily
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit complete embryonic lethality. Mice heterozygous for a null allele exhibit decreased susceptibility to LPS-induced lung injury.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 75717 NCBI Gene Model | MGI Sequence Detail 52926 C57BL/6J ±  kb
transcript NM_027807 RefSeq | MGI Sequence Detail 6023 C57BL/6  
polypeptide Q9D5V5 UniProt | EBI | MGI Sequence Detail 780 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    8 Sequences
  • PDB
  • InterPro Domains
    IPR016157 Cullin, conserved site
    IPR016158 Cullin homology domain
    IPR036317 Cullin homology domain superfamily
    IPR001373 Cullin, N-terminal
    IPR019559 Cullin protein, neddylation domain
    IPR016159 Cullin repeat-like-containing domain superfamily
    IPR036390 Winged helix DNA-binding domain superfamily
    IPR036388 Winged helix-like DNA-binding domain superfamily
Molecular
Reagents
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  • All nucleic 22
    cDNA 22

    Microarray probesets 8
Other
Accession IDs
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MGI:1918729, MGI:1924813, MGI:1925779, MGI:2143157
References
more
  • Summaries
    All 49
    Developmental Gene Expression 6
    Gene Ontology 9
    Phenotypes 8
  • Earliest
    J:38757 Byrd PJ, et al., Identification and analysis of expression of human VACM-1, a cullin gene family member located on chromosome 11q22-23 [letter]. Genome Res. 1997 Jan;7(1):71-5
  • Latest
    J:257927 Fairchild CL, et al., RBX2 maintains final retinal cell position in a DAB1-dependent and -independent fashion. Development. 2018 Feb 2;145(3)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory