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Tmem225 Gene Detail
Summary
  • Symbol
    Tmem225
  • Name
    transmembrane protein 225
  • Synonyms
    1700030E15Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1922917
    NCBI Gene: 75667
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:40059418-40062170 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 21.42 cM, cytoband B
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    48 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1922917
protein coding gene Chr9:40059418-40062176 (+)
129S1/SvImJ MGP_129S1SvImJ_G0034663
protein coding gene Chr9:38344993-38347746 (+)
A/J MGP_AJ_G0034643
protein coding gene Chr9:37346195-37348948 (+)
AKR/J MGP_AKRJ_G0034569
protein coding gene Chr9:38066851-38069604 (+)
BALB/cJ MGP_BALBcJ_G0034634
protein coding gene Chr9:37116940-37119693 (+)
C3H/HeJ MGP_C3HHeJ_G0034345
protein coding gene Chr9:38573163-38575916 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035157
protein coding gene Chr9:39573893-39576651 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032070
protein coding gene Chr9:37014950-37017702 (+)
CAST/EiJ MGP_CASTEiJ_G0033667
protein coding gene Chr9:38326545-38329317 (+)
CBA/J MGP_CBAJ_G0034318
protein coding gene Chr9:40932387-40935153 (+)
DBA/2J MGP_DBA2J_G0034477
protein coding gene Chr9:37313788-37316541 (+)
FVB/NJ MGP_FVBNJ_G0034417
protein coding gene Chr9:36525964-36528717 (+)
LP/J MGP_LPJ_G0034558
protein coding gene Chr9:38627505-38630258 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034461
protein coding gene Chr9:42987184-42989937 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035176
protein coding gene Chr9:37990001-37992754 (+)
PWK/PhJ MGP_PWKPhJ_G0033372
protein coding gene Chr9:37118084-37120846 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033209
protein coding gene Chr9:38221272-38224034 (+)
WSB/EiJ MGP_WSBEiJ_G0033780
protein coding gene Chr9:38002039-38004802 (+)



Homology
more
  • Human Ortholog
    TMEM225, transmembrane protein 225
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TMEM225, transmembrane protein 225
  • Synonyms
    PMP22CD, PPP1R154, SPATA47
  • Links
    NCBI Gene ID: 338661
    neXtProt AC: NX_Q6GV28
    UniProt: Q6GV28

  • Chr Location
    11q24.1; chr11:123882920-123886763 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    9 phenotypes from 1 allele in 1 genetic background
    2 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • cDNA Data
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000040541 Ensembl Gene Model | MGI Sequence Detail 2753 C57BL/6J ±  kb
    transcript ENSMUST00000046333 Ensembl | MGI Sequence Detail 987 Not Applicable  
    polypeptide ENSMUSP00000036816 Ensembl | MGI Sequence Detail 230 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 10
      cDNA 10

      Microarray probesets 4
    References
    more
    • Summaries
      All 24
      Gene Ontology 2
      Phenotypes 2
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:244826 Matsuura M, et al., TMEM225: a possible protein phosphatase 1gamma2 (PP1gamma2) regulator localizes to the equatorial segment in mouse spermatozoa. Mol Reprod Dev. 2015 Feb;82(2):139-48

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    last database update
    06/23/2022
    MGI 6.20
    The Jackson Laboratory