Tmem225 MGI Mouse Gene Detail - MGI:1922917

Symbol

Tmem225
Name

transmembrane protein 225
Synonyms

1700030E15Rik

Feature Type

protein coding gene
IDs

MGI:1922917
NCBI Gene: 75667
Alliance

genome feature page
Transcription Start Sites

2 TSS

Sequence Map

Chr9:40059418-40062170 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 9, 21.42 cM, cytoband B
Mapping Data

2 experiments

SNPs within 2kb

210 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1922917	protein coding gene	Chr9:40059418-40062176 (+)
129S1/SvImJ	ENSMUSG00200039642	protein coding gene	Chr9:37138459-37141206 (+)
A/J	ENSMUSG00195045000	protein coding gene	Chr9:36895241-36897988 (+)
AKR/J	ENSMUSG00220045076	protein coding gene	Chr9:36971802-36974549 (+)
BALB/cJ	ENSMUSG00180041503	protein coding gene	Chr9:37018520-37021267 (+)
C3H/HeJ	ENSMUSG00175042265	protein coding gene	Chr9:37019175-37021922 (+)
C57BL/6NJ	ENSMUSG00215017424	protein coding gene	Chr9:36967307-36970059 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0032070	protein coding gene	Chr9:37014950-37017702 (+)
CAST/EiJ	ENSTCUG00005043248	protein coding gene	Chr9:36957873-36960639 (+)
CBA/J	ENSMUSG00210044961	protein coding gene	Chr9:37054328-37057088 (+)
DBA/2J	ENSMUSG00185033703	protein coding gene	Chr9:37109594-37112341 (+)
FVB/NJ	ENSMUSG00205029587	protein coding gene	Chr9:37356195-37358942 (+)
JF1/MsJ	ENSUMUG00000041695	protein coding gene	Chr9:37165843-37168611 (+)
LP/J	ENSMUSG00230031821	protein coding gene	Chr9:37427615-37430362 (+)
NOD/ShiLtJ	ENSMUSG00190027403	protein coding gene	Chr9:37196087-37198834 (+)
NZO/HlLtJ	ENSMUSG00225020163	protein coding gene	Chr9:37396031-37398778 (+)
PWK/PhJ	ENSLUMG00010045812	protein coding gene	Chr9:37130692-37133448 (+)
SPRET/EiJ	ENSMSPG00010029474	protein coding gene	Chr9:37858011-37860741 (+)
WSB/EiJ	ENSIUOG00005043660	protein coding gene	Chr9:36617047-36619804 (+)

Human Ortholog

TMEM225, transmembrane protein 225

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TMEM225, transmembrane protein 225
Synonyms

PMP22CD, PPP1R154, SPATA47
Links

HGNC:32390

NCBI Gene ID: 338661

UniProt: Q6GV28
Chr Location

11q24.1; chr11:123882920-123885670 (-) GRCh38

MGI Vertebrate Homology

Tmem225 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: TMEM225
Gene Tree

Tmem225

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Phenotype Summary

23 phenotypes from 2 alleles in 2 genetic backgrounds
5 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

2
Endonuclease-mediated

2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

13 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Male mice homozygous for a knock-out allele are infertile and exhibit asthenospermia and an abnormal hairpin-loop configuration in cauda sperm flagella associated with impaired glycolysis, decreased ATP levels, high reactive oxygen species levels, and mitochondrial dysfunction.

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All GO Annotations

6
GO References

2

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

597
cDNA Data

10

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

37
RefSeq

4
UniProt

2
CCDS

CCDS52774.1

Ensembl

ENSMUSG00000040541 (Evidence)
NCBI Gene

75667

			Length	Strain/Species	Flank
genomic	ENSMUSG00000040541	Ensembl Gene Model \| MGI Sequence Detail	2753	C57BL/6J	± kb
transcript	ENSMUST00000046333	Ensembl \| MGI Sequence Detail	987	Not Applicable
polypeptide	ENSMUSP00000036816	Ensembl \| MGI Sequence Detail	230	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000029806 transmembrane protein 225

(term hierarchy)
InterPro Domains

IPR033542 Transmembrane protein 225

IPR057351 Transmembrane protein 225 domain

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All nucleic 10

cDNA 10

Microarray probesets 4

Summaries

All 26

Gene Ontology 2

Phenotypes 5
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345843 Lv Z, et al., TMEM225 Is Essential for Sperm Maturation and Male Fertility by Modifying Protein Distribution of Sperm in Mice. Mol Cell Proteomics. 2024 Feb;23(2):100720

TSS for Tmem225:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr84429	Chr9:40059408-40059428 (+)	0 bp
Tssr84430	Chr9:40059452-40059461 (+)	39 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/08/2026 MGI 6.24