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Ttll8 Gene Detail
Summary
  • Symbol
    Ttll8
  • Name
    tubulin tyrosine ligase-like family, member 8
  • Synonyms
    1700019P01Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1922902
    NCBI Gene: 239591
Location & Maps
more
  • Sequence Map
    Chr15:88890633-88954418 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      63786 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 44.39 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    TTLL8, tubulin tyrosine ligase like 8
  • Vertebrate Orthologs
    6
  • Human Ortholog
    TTLL8, tubulin tyrosine ligase like 8
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 164714
    neXtProt AC: NX_A6PVC2

  • Chr Location
    22q13.33; chr22:50018575-50059132 (-)  GRCh38.p2

Human Diseases
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  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    24 phenotype references
  • All Mutations and Alleles
    6
  • Chemically induced (other)
    1
  • Gene trapped
    1
  • Radiation induced
    2
  • Targeted
    2
  • Genomic Mutations
    3 involving Ttll8
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023602 VEGA Gene Model | MGI Sequence Detail 63786 C57BL/6J ±  kb
transcript OTTMUST00000057619 VEGA | MGI Sequence Detail 2968 Not Applicable  
polypeptide OTTMUSP00000027801 VEGA | MGI Sequence Detail 832 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    208 from dbSNP Build 142
Protein
Information
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  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000016797 protein monoglycylase TTLL8
  • EC
  • InterPro Domains
    IPR004344 Tubulin-tyrosine ligase/Tubulin polyglutamylase
Molecular
Reagents
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  • All nucleic 5
    cDNA 5

    Microarray probesets 1
References
more
  • Summaries
    All 22
    Diseases 1
    Gene Ontology 5
    Phenotypes 24
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:201638 Bosch Grau M, et al., Tubulin glycylases and glutamylases have distinct functions in stabilization and motility of ependymal cilia. J Cell Biol. 2013 Aug 5;202(3):441-51

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/27/2016
MGI 6.05
The Jackson Laboratory