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Med25
Gene Detail
Symbol

Name
ID
Med25
mediator complex subunit 25
MGI:1922863
Synonyms
2610034E13Rik, 2610529E18Rik, ESTM2
Feature Type
protein coding gene
Genetic Map
Chromosome 7
28.95 cM, cytoband B2
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr7:44879391-44892397 bp, - strand
From Ensembl annotation of GRCm38

  13007 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:12614  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog

HCOP human homology predictions: MED25
Gene Tree: Med25

Human
homologs
MED25, mediator complex subunit 25
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 81857
neXtProt AC: NX_Q71SY5

Human Synonyms: ACID1, ARC92, BVSYS, CMT2B2, P78, PTOV2, TCBAP0758

Human Chr (Location): 19q13.3; chr19:49818279-49840384 (+)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human MED25

Mutations,
alleles, and
phenotypes
All mutations/alleles(11) : Gene trapped(8) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Med25 interacts with 6 markers (Mir298, Mir546, Mir2136, ...)
Expression
Literature Summary: (3 records)
Data Summary: Results (123)    Tissues (16)    Images (22)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 123
cDNA source data(139)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase med25 ; ZFIN med25    NEW 
Molecular
reagents
All nucleic(139) cDNA(139)
Microarray probesets(5)
Other database
links
Ensembl Gene Model ENSMUSG00000002968 (Evidence)
Entrez Gene 75613 (Evidence)
UniGene 157778
DFCI TC1574489, TC1588121, TC1598951
DoTS DT.101249218, DT.101263929, DT.490938, DT.536448, DT.91296977, DT.94374125, DT.94392902, DT.97352556, DT.97357820, DT.97386852
NIA Mouse Gene Index U028504
Consensus CDS Project CCDS21220.1
International Mouse Phenotyping Consortium Status Med25
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000002968 Ensembl Gene Model | MGI Sequence Detail 13007 C57BL/6J ±  kb
transcript ENSMUST00000003049 Ensembl | MGI Sequence Detail 2297 Not Applicable 
polypeptide ENSMUSP00000003049 Ensembl | MGI Sequence Detail 745 Not Applicable 

For the selected sequences
All sequences(59) RefSeq(16) UniProt(1)
Polymorphisms
RFLP(1) : SNPs within 2kb(71 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR021406 Mediator complex, subunit Med25, NR box
InterPro IPR021394 Mediator complex, subunit Med25, PTOV activation and synapsin 2
InterPro IPR021397 Mediator complex, subunit Med25, synapsin 1
InterPro IPR021419 Mediator complex, subunit Med25, von Willebrand factor type A
InterPro IPR002035 von Willebrand factor, type A
Protein Ontology PR:000010297 mediator of RNA polymerase II transcription subunit 25
References
(Earliest) J:28401 Bettenhausen B, et al., Efficient isolation of novel mouse genes differentially expressed in early postimplantation embryos. Genomics. 1995 Aug 10;28(3):436-41
(Latest) J:205660 Nakamura Y, et al., Wwp2 is essential for palatogenesis mediated by the interaction between Sox9 and mediator subunit 25. Nat Commun. 2011;2:251
All references(36)
Other
accession IDs
MGD-MRK-28123, MGI:104829

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory