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Med25 Gene Detail
Summary
  • Symbol
    Med25
  • Name
    mediator complex subunit 25
  • Synonyms
    2610034E13Rik, 2610529E18Rik, ESTM2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1922863
    NCBI Gene: 75613
  • Gene Overview
    MyGene.info: MED25
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:44876765-44892664 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 28.95 cM, cytoband B2
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    82 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1922863
protein coding gene Chr7:44876765-44892712 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032184
protein coding gene Chr7:45087406-45101637 (-)
A/J MGP_AJ_G0032163
protein coding gene Chr7:44242930-44256677 (-)
AKR/J MGP_AKRJ_G0032099
protein coding gene Chr7:45460251-45474845 (-)
BALB/cJ MGP_BALBcJ_G0032175
protein coding gene Chr7:44242864-44255969 (-)
C3H/HeJ MGP_C3HHeJ_G0031891
protein coding gene Chr7:45962254-45975755 (-)
C57BL/6NJ MGP_C57BL6NJ_G0032667
protein coding gene Chr7:47353170-47365905 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029681
protein coding gene Chr7:46813162-46826165 (-)
CAST/EiJ MGP_CASTEiJ_G0031219
protein coding gene Chr7:37335049-37349133 (-)
CBA/J MGP_CBAJ_G0031855
protein coding gene Chr7:48908354-48921179 (-)
DBA/2J MGP_DBA2J_G0032013
protein coding gene Chr7:43913948-43926714 (-)
FVB/NJ MGP_FVBNJ_G0031964
protein coding gene Chr7:43691338-43704641 (-)
LP/J MGP_LPJ_G0032091
protein coding gene Chr7:45769863-45785498 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032001
protein coding gene Chr7:47641110-47655055 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0032683
protein coding gene Chr7:44684564-44699006 (-)
PWK/PhJ MGP_PWKPhJ_G0030942
protein coding gene Chr7:37278324-37291876 (-)
SPRET/EiJ MGP_SPRETEiJ_G0030779
protein coding gene Chr7:32683413-32698790 (-)
WSB/EiJ MGP_WSBEiJ_G0031336
protein coding gene Chr7:45157677-45171175 (-)



Homology
more
  • Human Ortholog
    MED25, mediator complex subunit 25
  • Vertebrate Orthologs
    8
  • Human Ortholog
    MED25, mediator complex subunit 25
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ACID1, ARC92, BVSYS, CMT2B2, P78, PTOV2, TCBAP0758
  • Links
    NCBI Gene ID: 81857
    neXtProt AC: NX_Q71SY5
    UniProt: Q71SY5

  • Chr Location
    19q13.33; chr19:49818279-49840384 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human MED25 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 75613 NCBI Gene Model | MGI Sequence Detail 15900 C57BL/6J ±  kb
    transcript NM_001331207 RefSeq | MGI Sequence Detail 3726 C57BL/6  
    polypeptide Q8VCB2 UniProt | EBI | MGI Sequence Detail 745 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      9 Sequences
    • InterPro Domains
      IPR021406 Mediator complex, subunit Med25, NR box
      IPR021394 Mediator complex, subunit Med25, PTOV domain
      IPR021397 Mediator complex, subunit Med25, synapsin 1
      IPR021419 Mediator complex, subunit Med25, von Willebrand factor type A
      IPR038196 PTOV domain superfamily
      IPR036465 von Willebrand factor A-like domain superfamily
    Molecular
    Reagents
    less
    • All nucleic 140
      cDNA 140

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-28123, MGI:104829
    References
    more
    • Summaries
      All 36
      Developmental Gene Expression 3
      Gene Ontology 4
      Phenotypes 9
    • Earliest
      J:28401 Bettenhausen B, et al., Efficient isolation of novel mouse genes differentially expressed in early postimplantation embryos. Genomics. 1995 Aug 10;28(3):436-41
    • Latest
      J:236599 Dickinson ME, et al., High-throughput discovery of novel developmental phenotypes. Nature. 2016 Sep 14;537(7621):508-514

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory