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Med25 Gene Detail
Summary
  • Symbol
    Med25
  • Name
    mediator complex subunit 25
  • Synonyms
    2610034E13Rik, 2610529E18Rik, ESTM2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1922863
    NCBI Gene: 75613
  • Gene Overview
    MyGene.info: MED25
Location & Maps
more
  • Sequence Map
    Chr7:44876765-44892712 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      15948 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 28.95 cM, cytoband B2
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    MED25, mediator complex subunit 25
  • Vertebrate Orthologs
    8
  • Human Ortholog
    MED25, mediator complex subunit 25
    Orthology source: HGNC, HomoloGene
  • Synonyms
    ACID1, ARC92, BVSYS, CMT2B2, P78, PTOV2, TCBAP0758
  • Links
    NCBI Gene ID: 81857
    neXtProt AC: NX_Q71SY5

  • Chr Location
    19q13.3; chr19:49818279-49840384 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    2 with human MED25 associations

Human Disease Mouse Models
       Basel-Vanagaite-Smirin-Yosef Syndrome; BVSYS   OMIM: 616449
Charcot-Marie-Tooth Disease, Axonal, Type 2B2; CMT2B2   OMIM: 605589
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    11
  • Gene trapped
    8
  • Targeted
    3
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000058334 VEGA Gene Model | MGI Sequence Detail 15948 C57BL/6J ±  kb
transcript OTTMUST00000143230 VEGA | MGI Sequence Detail 3693 Not Applicable  
polypeptide OTTMUSP00000074675 VEGA | MGI Sequence Detail 801 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    82 from dbSNP Build 142
  • RFLP
Protein
Information
less
  • UniProt
    9 Sequences
  • Protein Ontology
    PR:000010297 mediator of RNA polymerase II transcription subunit 25
  • InterPro Domains
    IPR021406 Mediator complex, subunit Med25, NR box
    IPR021394 Mediator complex, subunit Med25, PTOV activation and synapsin 2
    IPR021397 Mediator complex, subunit Med25, synapsin 1
    IPR021419 Mediator complex, subunit Med25, von Willebrand factor type A
    IPR002035 von Willebrand factor, type A
Molecular
Reagents
less
  • All nucleic 139
    cDNA 139

    Microarray probesets 5
Other
Accession IDs
less
MGD-MRK-28123, MGI:104829
References
more
  • Summaries
    All 36
    Developmental Gene Expression 3
    Gene Ontology 4
    Phenotypes 8
  • Earliest
    J:28401 Bettenhausen B, et al., Efficient isolation of novel mouse genes differentially expressed in early postimplantation embryos. Genomics. 1995 Aug 10;28(3):436-41
  • Latest
    J:205660 Nakamura Y, et al., Wwp2 is essential for palatogenesis mediated by the interaction between Sox9 and mediator subunit 25. Nat Commun. 2011;2:251

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory