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Med25
Gene Detail
 Symbol
Name
ID
Med25
mediator complex subunit 25
MGI:1922863
Synonyms 2610034E13Rik, 2610529E18Rik, ESTM2
Feature Type protein coding gene
Genetic Map
Chromosome 7
28.95 cM, cytoband B2
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr7:44879386-44892366 bp, - strand
From NCBI annotation of GRCm38

  12981 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:12614  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog

Gene Tree: Med25

Human
homologs
Human Homolog MED25, mediator complex subunit 25
NCBI Gene ID 81857
neXtProt AC  NX_Q71SY5
Human Synonyms  ACID1, ARC92, CMT2B2, P78, PTOV2
Human Chr (Location)  19q13.3; chr19:49818279-49836980 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human MED25
Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Gene trapped(8) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Med25 interacts with 6 markers (Mir298, Mir546, Mir2136, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process negative regulation of fibroblast proliferation, negative regulation of transcription from RNA polymerase II promoter, ...
Component nucleus
Function retinoic acid receptor binding, retinoid X receptor binding, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (123)    Tissues (16)    Images (22)
Theiler Stages: 23
Assay TypeResults
RNA in situ 123
cDNA source data(139)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(139) cDNA(139)
Microarray probesets(5)
Other database
links
Ensembl Gene ModelENSMUSG00000002968 (Evidence)
Entrez Gene75613 (Evidence)
UniGene157778
DFCITC1574489, TC1588121, TC1598951
DoTSDT.101249218, DT.101263929, DT.490938, DT.536448, DT.91296977, DT.94374125, DT.94392902, DT.97352556, DT.97357820, DT.97386852
NIA Mouse Gene IndexU028504
Consensus CDS ProjectCCDS21220.1
International Mouse Knockout Project StatusMed25
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 75613 NCBI Gene Model | MGI Sequence Detail 12981 C57BL/6J ±  kb
transcript NM_029365 RefSeq | MGI Sequence Detail 2291 Not Specified 
polypeptide Q8VCB2 UniProt | EBI | MGI Sequence Detail 745 Not Applicable 

For the selected sequences
All sequences(53) RefSeq(14) UniProt(1)
Polymorphisms RFLP(1) : SNPs within 2kb(70 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR021406 Mediator complex, subunit Med25, NR box
InterPro IPR021394 Mediator complex, subunit Med25, PTOV activation and synapsin 2
InterPro IPR021397 Mediator complex, subunit Med25, synapsin 1
InterPro IPR021419 Mediator complex, subunit Med25, von Willebrand factor type A
InterPro IPR002035 von Willebrand factor, type A
Protein Ontology PR:000010297 mediator of RNA polymerase II transcription subunit 25
Graphical View of Protein Domain Structure
References (Earliest) J:28401 Bettenhausen B, et al., Efficient isolation of novel mouse genes differentially expressed in early postimplantation embryos. Genomics. 1995 Aug 10;28(3):436-41
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(36)
Other
accession IDs
MGD-MRK-28123, MGI:104829

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory