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Chmp4b
Gene Detail
Symbol

Name
ID
Chmp4b
charged multivesicular body protein 4B
MGI:1922858
Synonyms
2010012F05Rik, chromatin modifying protein 4B, Snf7-2
Feature Type
protein coding gene
Genetic Map
Chromosome 2
76.79 cM, cytoband H2
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr2:154651705-154694785 bp, + strand
From VEGA annotation of GRCm38

  43081 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:57102  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: CHMP4B
Protein SuperFamily: ESCRT-3 complex, Chmp4/Chmp5/Chmp6 subunits
Gene Tree: Chmp4b

Human
homologs
CHMP4B, charged multivesicular body protein 4B
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 128866
neXtProt AC: NX_Q9H444

Human Synonyms: C20orf178, CHMP4A, CTPP3, CTRCT31, dJ553F4.4, Shax1, SNF7, SNF7-2, Vps32-2, VPS32B

Human Chr (Location): 20q11.22; chr20:33811304-33854367 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human CHMP4B

Mutations,
alleles, and
phenotypes
All mutations/alleles(53) : Gene trapped(51) Targeted(2)
 
Mice homozygous for a gene trap insertion die between E7.5 and E8.5.
 
Interactions
Chmp4b interacts with 145 markers (Mir10a, Mir15a, Mir16-1, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (1 records)
Data Summary: Results (22)    Tissues (19)    Tissue x Stage Matrix (view)
Assay TypeResults
Western blot 22
cDNA source data(112)
Other mouse links: GEO   Expression Atlas
Other vertebrate links: Xenbase chmp4b ; ZFIN chmp4bb    NEW 
Molecular
reagents
All nucleic(112) cDNA(112)
Microarray probesets(6)
Other database
links
VEGA Gene Model OTTMUSG00000015914 (Evidence)
Ensembl Gene Model ENSMUSG00000038467 (Evidence)
Entrez Gene 75608 (Evidence)
UniGene 262480
DFCI TC1574209, TC1659160
DoTS DT.101400108, DT.101400110, DT.533201
NIA Mouse Gene Index U002691
Consensus CDS Project CCDS16938.1
International Mouse Phenotyping Consortium Status Chmp4b
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000015914 VEGA Gene Model | MGI Sequence Detail 43081 C57BL/6J ±  kb
transcript OTTMUST00000037805 VEGA | MGI Sequence Detail 1616 Not Applicable 
polypeptide OTTMUSP00000016972 VEGA | MGI Sequence Detail 224 Not Applicable 

For the selected sequences
All sequences(36) RefSeq(2) UniProt(1)
Polymorphisms
SNPs within 2kb(325 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR005024 Snf7
Protein Ontology PR:000005437 charged multivesicular body protein 4b
References
(Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:219860 Chassefeyre R, et al., Regulation of postsynaptic function by the dementia-related ESCRT-III subunit CHMP2B. J Neurosci. 2015 Feb 18;35(7):3155-73
All references(37)
Other
accession IDs
MGI:2139458

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory