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Kdm5b
Gene Detail
Symbol

Name
ID
Kdm5b
lysine (K)-specific demethylase 5B
MGI:1922855
Synonyms
2010009J12Rik, 2210016I17Rik, D1Ertd202e, Jarid1b, Plu1, PLU-1, Rb-Bp2
Feature Type
protein coding gene
Genetic Map
Chromosome 1
58.24 cM, cytoband E4
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr1:134560171-134635285 bp, + strand
From VEGA annotation of GRCm38

  75115 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:48448  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: KDM5B
Protein SuperFamily: histone H3 lysine 4 demethylase (Jumonji/ARID domain-containing protein)
Gene Tree: Kdm5b

Human
homologs
KDM5B, lysine (K)-specific demethylase 5B
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 10765
neXtProt AC: NX_Q9UGL1

Human Synonyms: CT31, JARID1B, PLU1, PLU-1, PPP1R98, PUT1, RBBP2H1A

Human Chr (Location): 1q32.1; chr1:202727403-202808468 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(234) : Gene trapped(232) Targeted(2)
Incidental mutations (data from Mutagenetix , APF , CvDC )
Interactions
Kdm5b interacts with 305 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (11 records)
Data Summary: Results (207)    Tissues (134)    Images (40)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 144
Northern blot 10
Western blot 2
RT-PCR 51
cDNA source data(21)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase kdm5b ; ZFIN kdm5ba, kdm5bb    NEW 
Molecular
reagents
All nucleic(25) cDNA(21) Primer pair(4)
Microarray probesets(7)
Other database
links
VEGA Gene Model OTTMUSG00000017092 (Evidence)
Ensembl Gene Model ENSMUSG00000042207 (Evidence)
Entrez Gene 75605 (Evidence)
DFCI TC1572318, TC1604227, TC1586359, TC1603897, TC1602675
DoTS DT.524665, DT.110911729, DT.101388665, DT.91369634, DT.94139790, DT.97352627
NIA Mouse Gene Index U000832
EC 1.14.11.-
PDB 2EQY
Consensus CDS Project CCDS35716.1
International Mouse Phenotyping Consortium Status Kdm5b
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017092 VEGA Gene Model | MGI Sequence Detail 75115 C57BL/6J ±  kb
transcript OTTMUST00000041390 VEGA | MGI Sequence Detail 8714 Not Applicable 
polypeptide OTTMUSP00000018570 VEGA | MGI Sequence Detail 1544 Not Applicable 

For the selected sequences
All sequences(69) RefSeq(4) UniProt(4)
Polymorphisms
SNPs within 2kb(578 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001606 ARID/BRIGHT DNA-binding domain
InterPro IPR003347 JmjC domain
InterPro IPR013637 Lysine-specific demethylase-like domain
InterPro IPR003349 Transcription factor jumonji, JmjN
InterPro IPR004198 Zinc finger, C5HC2-type
InterPro IPR011011 Zinc finger, FYVE/PHD-type
InterPro IPR019787 Zinc finger, PHD-finger
InterPro IPR001965 Zinc finger, PHD-type
InterPro IPR019786 Zinc finger, PHD-type, conserved site
InterPro IPR013083 Zinc finger, RING/FYVE/PHD-type
Protein Ontology PR:000009205 lysine-specific demethylase 5B
References
(Earliest) J:28008 Harrison SM, et al., Isolation of novel tissue-specific genes from cDNA libraries representing the individual tissue constituents of the gastrulating mouse embryo. Development. 1995 Aug;121(8):2479-89
(Latest) J:218960 Zou MR, et al., Histone demethylase jumonji AT-rich interactive domain 1B (JARID1B) controls mammary gland development by regulating key developmental and lineage specification genes. J Biol Chem. 2014 Jun 20;289(25):17620-33
All references(66)
Other
accession IDs
MGI:1098818, MGI:1917371, MGI:2138618

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory