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Ppp1r35 Gene Detail
Summary
  • Symbol
    Ppp1r35
  • Name
    protein phosphatase 1, regulatory subunit 35
  • Synonyms
    2010007H12Rik, 2010011D20Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1922853
    NCBI Gene: 69871
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:137778904-137780110 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 76.70 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    8 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1922853
protein coding gene Chr5:137778849-137780110 (+)
129S1/SvImJ MGP_129S1SvImJ_G0030243
protein coding gene Chr5:142575025-142576286 (+)
A/J MGP_AJ_G0030211
protein coding gene Chr5:136354507-136355768 (+)
AKR/J MGP_AKRJ_G0030144
protein coding gene Chr5:140783939-140785199 (+)
BALB/cJ MGP_BALBcJ_G0030221
protein coding gene Chr5:137741068-137742329 (+)
C3H/HeJ MGP_C3HHeJ_G0029937
protein coding gene Chr5:141446224-141447485 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030673
protein coding gene Chr5:147838648-147839909 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027891
protein coding gene Chr5:130586728-130587980 (+)
CAST/EiJ MGP_CASTEiJ_G0029347
protein coding gene Chr5:140841799-140843057 (+)
CBA/J MGP_CBAJ_G0029907
protein coding gene Chr5:153724712-153725973 (+)
DBA/2J MGP_DBA2J_G0030058
protein coding gene Chr5:136264239-136265500 (+)
FVB/NJ MGP_FVBNJ_G0030013
protein coding gene Chr5:135457059-135458320 (+)
LP/J MGP_LPJ_G0030147
protein coding gene Chr5:143056214-143057475 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030045
protein coding gene Chr5:156525341-156538959 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030714
protein coding gene Chr5:140639890-140641151 (+)
PWK/PhJ MGP_PWKPhJ_G0029060
protein coding gene Chr5:135342163-135343415 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028896
protein coding gene Chr5:138204693-138205949 (+)
WSB/EiJ MGP_WSBEiJ_G0029420
protein coding gene Chr5:141369687-141370948 (+)



Homology
more
  • Human Ortholog
    PPP1R35, protein phosphatase 1 regulatory subunit 35
  • Vertebrate Orthologs
    6
  • Human Ortholog
    PPP1R35, protein phosphatase 1 regulatory subunit 35
    Orthology source: HomoloGene, HGNC
  • Synonyms
    C7orf47
  • Links
    NCBI Gene ID: 221908
    neXtProt AC: NX_Q8TAP8
    UniProt: Q8TAP8

  • Chr Location
    7q22.1; chr7:100435282-100436615 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    16 phenotypes from 1 allele in 2 genetic backgrounds
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele show embryonic growth retardation, failure of embryo turning, distended pericardium, increased neural tube cell death, and embryonic lethality during early organogenesis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 69871 NCBI Gene Model | MGI Sequence Detail 1207 C57BL/6J ±  kb
    transcript NM_027242 RefSeq | MGI Sequence Detail 953 C57BL/6  
    polypeptide Q9D8C8 UniProt | EBI | MGI Sequence Detail 260 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000031115 protein phosphatase 1 regulatory subunit 35
    • InterPro Domains
      IPR033590 Protein phosphatase 1 regulatory subunit 35
      IPR029135 Protein phosphatase 1 regulatory subunit 35, C-terminal
    Molecular
    Reagents
    less
    • All nucleic 30
      cDNA 29
      Primer pair 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1917121, MGI:2141018
    References
    more
    • Summaries
      All 30
      Developmental Gene Expression 1
      Gene Ontology 4
      Phenotypes 7
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:236599 Dickinson ME, et al., High-throughput discovery of novel developmental phenotypes. Nature. 2016 Sep 14;537(7621):508-514

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    last database update
    05/19/2020
    MGI 6.15
    The Jackson Laboratory