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Ndufaf2
Gene Detail
Symbol

Name
ID
Ndufaf2
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, assembly factor 2
MGI:1922847
Synonyms
1810058I14Rik, mimitin, Ndufa12l
Feature Type
protein coding gene
Genetic Map
Chromosome 13
59.63 cM, cytoband D2.1
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr13:108052590-108158625 bp, - strand
From Ensembl annotation of GRCm38

  106036 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:18372  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Ndufaf2

Human
homologs
Human Homolog NDUFAF2, NADH dehydrogenase (ubiquinone) complex I, assembly factor 2
NCBI Gene ID 91942
neXtProt AC  NX_Q8N183
Human Synonyms  B17.2L, mimitin, MMTN, NDUFA12L
Human Chr (Location)  5q12.1; chr5:60945129-61153037 (+)  GRCh38
Disease Associations  (2) Diseases Associated with Human NDUFAF2
Mutations,
alleles, and
phenotypes
All mutations/alleles(28) : Gene trapped(25) Targeted(3)
 
Mice homozygous for a knock-out allele exhibit impaired complex I mitochondrial activity.
 
Interactions
Ndufaf2 interacts with 18 markers (Mir22, Mir29b-2, Mir31, ...)
Gene Ontology
(GO)
classifications
Expression
cDNA source data(19)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(19) cDNA(19)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000068184 (Evidence)
Entrez Gene75597 (Evidence)
UniGene276040
DFCITC1612844
DoTSDT.110957050, DT.486723
Consensus CDS ProjectCCDS49357.1
International Mouse Knockout Project StatusNdufaf2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000068184 Ensembl Gene Model | MGI Sequence Detail 106036 C57BL/6J ±  kb
transcript ENSMUST00000163558 Ensembl | MGI Sequence Detail 679 Not Applicable 
polypeptide ENSMUSP00000130532 Ensembl | MGI Sequence Detail 168 Not Applicable 

For the selected sequences
All sequences(24) RefSeq(4) UniProt(2)
Polymorphisms
SNPs within 2kb(837 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
Protein Ontology PR:000011082 mimitin, mitochondrial
References
(Earliest) J:1921 Timsit SG, et al., DM-20 mRNA is expressed during the embryonic development of the nervous system of the mouse. J Neurochem. 1992 Mar;58(3):1172-5
(Latest) J:201547 Schlehe JS, et al., The mitochondrial disease associated protein Ndufaf2 is dispensable for Complex-1 assembly but critical for the regulation of oxidative stress. Neurobiol Dis. 2013 Oct;58:57-67
All references(37)
Other
accession IDs
MGI:2145529

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory