Eppin MGI Mouse Gene Detail - MGI:1922776 - epididymal peptidase inhibitor

Symbol

Eppin
Name

epididymal peptidase inhibitor
Synonyms

1700024E17Rik, Spinlw1

Feature Type

protein coding gene
IDs

MGI:1922776
NCBI Gene: 75526
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr2:164430263-164435491 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 85.21 cM, cytoband H3
Mapping Data

4 experiments

SNPs within 2kb

97 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1922776	protein coding gene	Chr2:164430263-164435514 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0026860	protein coding gene	Chr2:170055795-170061048 (-)
A/J	MGP_AJ_G0026827	protein coding gene	Chr2:163121300-163126551 (-)
AKR/J	MGP_AKRJ_G0026796	protein coding gene	Chr2:167963176-167968417 (-)
BALB/cJ	MGP_BALBcJ_G0026835	protein coding gene	Chr2:163482252-163487495 (-)
C3H/HeJ	MGP_C3HHeJ_G0026576	protein coding gene	Chr2:168326031-168331284 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0027282	protein coding gene	Chr2:174995487-175000738 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024652	protein coding gene	Chr2:156525048-156530401 (-)
CAST/EiJ	MGP_CASTEiJ_G0026036	protein coding gene	Chr2:168745708-168751136 (-)
CBA/J	MGP_CBAJ_G0026554	protein coding gene	Chr2:181324513-181329762 (-)
DBA/2J	MGP_DBA2J_G0026692	protein coding gene	Chr2:162289461-162294714 (-)
FVB/NJ	MGP_FVBNJ_G0026658	protein coding gene	Chr2:160709818-160715057 (-)
LP/J	MGP_LPJ_G0026794	protein coding gene	Chr2:170137882-170143135 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0026678	protein coding gene	Chr2:184904729-184909968 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0027340	protein coding gene	Chr2:167873967-167879216 (-)
PWK/PhJ	MGP_PWKPhJ_G0025773	protein coding gene	Chr2:161889326-161894658 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0025574	protein coding gene	Chr2:166772828-166778078 (-)
WSB/EiJ	MGP_WSBEiJ_G0026108	protein coding gene	Chr2:168746764-168752013 (-)

Human Ortholog

EPPIN, epididymal peptidase inhibitor

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

EPPIN, epididymal peptidase inhibitor
Synonyms

CT71, CT72, dJ461P17.2, SPINLW1, WAP7, WFDC7
Links

HGNC:15932

NCBI Gene ID: 57119

neXtProt AC: NX_O95925

UniProt: O95925
Chr Location

20q13.12; chr20:45540626-45547752 (-) GRCh38

Human Ortholog

EPPIN-WFDC6, EPPIN-WFDC6 readthrough
Synonyms

SPINLW1-WFDC6
Links

HGNC:38825

NCBI Gene ID: 100526773

neXtProt AC: NX_O95925
Chr Location

20q13.12; chr20:45534196-45547662 (-) GRCh38

MGI Vertebrate Homology

Eppin stringent orthology
2 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: EPPIN, EPPIN-WFDC6
Gene Tree

Eppin

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Phenotype Summary

17 phenotypes from 1 allele in 1 genetic background
3 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

2
Endonuclease-mediated

2
Incidental Mutations

APF
Find Mice (IMSR)

6 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

14
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

752
Tissues

20
cDNA Data

6
Literature Summary

3

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

28
RefSeq

2
UniProt

1
CCDS

CCDS17043.1

Ensembl

ENSMUSG00000017733 (Evidence)
NCBI Gene

75526

			Length	Strain/Species	Flank
genomic	75526	NCBI Gene Model \| MGI Sequence Detail	5229	C57BL/6J	± kb
transcript	NM_029325	RefSeq \| MGI Sequence Detail	755	C57BL/6
polypeptide	Q9DA01	UniProt \| EBI \| MGI Sequence Detail	134	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000015541 eppin

(term hierarchy)
InterPro Domains

IPR036645 Elafin-like superfamily

IPR002223 Pancreatic trypsin inhibitor Kunitz domain

IPR036880 Pancreatic trypsin inhibitor Kunitz domain superfamily

IPR020901 Proteinase inhibitor I2, Kunitz, conserved site

IPR008197 WAP-type 'four-disulfide core' domain

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All nucleic 7

cDNA 6

Primer pair 1

Microarray probesets 2

Summaries

All 31

Developmental Gene Expression 3

Gene Ontology 7

Phenotypes 3
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:287735 Mariani NAP, et al., Epididymal protease inhibitor (EPPIN) is a protein hub for seminal vesicle-secreted protein SVS2 binding in mouse spermatozoa. Mol Cell Endocrinol. 2020 Apr 15;506:110754

TSS for Eppin:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr27506	Chr2:164435526-164435535 (-)	-40 bp
Tssr27505	Chr2:164435508-164435523 (-)	-25 bp
Tssr27504	Chr2:164435458-164435497 (-)	13 bp
Tssr27503	Chr2:164435453-164435457 (-)	36 bp
Tssr27502	Chr2:164435434-164435446 (-)	51 bp
Tssr27501	Chr2:164431488-164431503 (-)	3,995 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23