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Tti1 Gene Detail
Summary
  • Symbol
    Tti1
  • Name
    TELO2 interacting protein 1
  • Synonyms
    2610036D13Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1922675
    NCBI Gene: 75425
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:157981803-158028433 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 78.68 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    262 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1922675
protein coding gene Chr2:157981803-158028476 (-)
129S1/SvImJ MGP_129S1SvImJ_G0026787
protein coding gene Chr2:163024550-163074590 (-)
A/J MGP_AJ_G0026753
protein coding gene Chr2:156495919-156543083 (-)
AKR/J MGP_AKRJ_G0026724
protein coding gene Chr2:161118116-161164588 (-)
BALB/cJ MGP_BALBcJ_G0026762
protein coding gene Chr2:156800830-156847707 (-)
C3H/HeJ MGP_C3HHeJ_G0026504
protein coding gene Chr2:161420959-161470757 (-)
C57BL/6NJ MGP_C57BL6NJ_G0027211
protein coding gene Chr2:167875981-167922942 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024581
protein coding gene Chr2:149937634-149988353 (-)
CAST/EiJ MGP_CASTEiJ_G0025966
protein coding gene Chr2:161781330-161828020 (-)
CBA/J MGP_CBAJ_G0026481
protein coding gene Chr2:173907087-173956675 (-)
DBA/2J MGP_DBA2J_G0026619
protein coding gene Chr2:155672149-155719082 (-)
FVB/NJ MGP_FVBNJ_G0026586
protein coding gene Chr2:154072977-154119577 (-)
LP/J MGP_LPJ_G0026722
protein coding gene Chr2:163108685-163158750 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0026607
protein coding gene Chr2:177730695-177778263 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027267
protein coding gene Chr2:160921761-160970642 (-)
PWK/PhJ MGP_PWKPhJ_G0025700
protein coding gene Chr2:155189356-155236644 (-)
SPRET/EiJ MGP_SPRETEiJ_G0025503
protein coding gene Chr2:159852403-159899226 (-)
WSB/EiJ MGP_WSBEiJ_G0026036
protein coding gene Chr2:161829632-161878021 (-)



Homology
more
  • Human Ortholog
    TTI1, TELO2 interacting protein 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    TTI1, TELO2 interacting protein 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    KIAA0406, smg-10
  • Links
    NCBI Gene ID: 9675
    neXtProt AC: NX_O43156
    UniProt: O43156

  • Chr Location
    20q11.23; chr20:37983007-38033468 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000027650 Ensembl Gene Model | MGI Sequence Detail 46631 C57BL/6J ±  kb
transcript ENSMUST00000029179 Ensembl | MGI Sequence Detail 3830 Not Applicable  
polypeptide ENSMUSP00000029179 Ensembl | MGI Sequence Detail 1085 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 52
    cDNA 52

    Microarray probesets 3
Other
Accession IDs
less
MGI:2138955
References
more
  • Summaries
    All 31
    Gene Ontology 2
    Phenotypes 8
  • Earliest
    J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-Le-Grand). 1999 Jul;45(5):737-50
  • Latest
    J:212482 Rao F, et al., Inositol pyrophosphates mediate the DNA-PK/ATM-p53 cell death pathway by regulating CK2 phosphorylation of Tti1/Tel2. Mol Cell. 2014 Apr 10;54(1):119-32

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
10/01/2019
MGI 6.14
The Jackson Laboratory