Secisbp2 MGI Mouse Gene Detail - MGI:1922670

Symbol

Secisbp2
Name

SECIS binding protein 2
Synonyms

2210413N07Rik, 2810012K13Rik, SBP2

Feature Type

protein coding gene
IDs

MGI:1922670
NCBI Gene: 75420
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr13:51805733-51838080 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 13, 26.12 cM, cytoband B1
Mapping Data

2 experiments

SNPs within 2kb

190 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1922670	protein coding gene	Chr13:51805721-51838080 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0020552	protein coding gene	Chr13:50874757-50911231 (+)
A/J	MGP_AJ_G0020506	protein coding gene	Chr13:49070926-49104397 (+)
AKR/J	MGP_AKRJ_G0020484	protein coding gene	Chr13:50465297-50497443 (+)
BALB/cJ	MGP_BALBcJ_G0020502	protein coding gene	Chr13:49259304-49291391 (+)
C3H/HeJ	MGP_C3HHeJ_G0020301	protein coding gene	Chr13:50305823-50340755 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0020936	protein coding gene	Chr13:52442196-52475354 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018518	protein coding gene	Chr13:46868588-46901541 (+)
CAST/EiJ	MGP_CASTEiJ_G0019815	protein coding gene	Chr13:50266749-50303383 (+)
CBA/J	MGP_CBAJ_G0020261	protein coding gene	Chr13:54473870-54509018 (+)
DBA/2J	MGP_DBA2J_G0020384	protein coding gene	Chr13:48638418-48671146 (+)
FVB/NJ	MGP_FVBNJ_G0020363	protein coding gene	Chr13:48066540-48098408 (+)
LP/J	MGP_LPJ_G0020460	protein coding gene	Chr13:51145100-51179779 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020392	protein coding gene	Chr13:54072015-54110919 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020979	protein coding gene	Chr13:50038507-50074099 (+)
PWK/PhJ	MGP_PWKPhJ_G0019572	protein coding gene	Chr13:48559067-48593038 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0019399	protein coding gene	Chr13:48925411-48962823 (+)
WSB/EiJ	MGP_WSBEiJ_G0019877	protein coding gene	Chr13:50347090-50378739 (+)

Human Ortholog

SECISBP2, SECIS binding protein 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SECISBP2, SECIS binding protein 2
Synonyms

SBP2, THMA1
Links

HGNC:30972

NCBI Gene ID: 79048

neXtProt AC: NX_Q96T21

UniProt: Q96T21
Chr Location

9q22.2; chr9:89318500-89367117 (+) GRCh38

MGI Vertebrate Homology

Secisbp2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SECISBP2
Gene Tree

Secisbp2

Diseases

1 with human SECISBP2 associations

				Human Disease	Mouse Models
				thyroid gland disease IDs thyroid gland disease DOID:50 ICD10CM:E07.9 ICD9CM:240-246.99 ICD9CM:246.9 MESH:D013959 NCI:C26893 UMLS_CUI:C0040128

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

22 phenotypes from 5 alleles in 6 genetic backgrounds
21 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

21
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

14
Targeted

5
Genomic Mutations

1 involving Secisbp2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

56 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit complete preweaning lethality while heterozygotes exhibit reduced serum selenium levels.

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All GO Annotations

25
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

714
Tissues

4
cDNA Data

55
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase secisbp2

ZFIN secisbp2

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All Sequences

57
RefSeq

11
UniProt

2
CCDS

CCDS36665.1

Ensembl

ENSMUSG00000035139 (Evidence)
NCBI Gene

75420

			Length	Strain/Species	Flank
genomic	ENSMUSG00000035139	Ensembl Gene Model \| MGI Sequence Detail	32348	C57BL/6J	± kb
transcript	ENSMUST00000040117	Ensembl \| MGI Sequence Detail	3328	Not Applicable
polypeptide	ENSMUSP00000045740	Ensembl \| MGI Sequence Detail	858	Not Applicable

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UniProt

2 Sequences
InterPro Domains

IPR040051 Selenocysteine insertion sequence-binding protein 2

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All nucleic 57

cDNA 57

Microarray probesets 5

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MGI:1919610

Summaries

All 52

Developmental Gene Expression 1

Gene Ontology 7

Phenotypes 21
Earliest

J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
Latest

J:343229 Schoenmakers E, et al., Selenoprotein deficiency disorder predisposes to aortic aneurysm formation. Nat Commun. 2023 Dec 2;14(1):7994

TSS for Secisbp2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr119765	Chr13:51805609-51805618 (+)	-119 bp
Tssr119766	Chr13:51805727-51805738 (+)	0 bp
Tssr119767	Chr13:51805745-51805782 (+)	31 bp
Tssr119768	Chr13:51805797-51805813 (+)	72 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23