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Secisbp2 Gene Detail
Summary
  • Symbol
    Secisbp2
  • Name
    SECIS binding protein 2
  • Synonyms
    2210413N07Rik, 2810012K13Rik, SBP2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1922670
    NCBI Gene: 75420
  • Gene Overview
    MyGene.info: SECISBP2
Location & Maps
more
  • Sequence Map
    Chr13:51651697-51684044 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      32348 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    SECISBP2, SECIS binding protein 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SECISBP2, SECIS binding protein 2
    Orthology source: HomoloGene
  • Synonyms
    SBP2
  • Links
    NCBI Gene ID: 79048
    neXtProt AC: NX_Q96T21

  • Chr Location
    9q22.2; chr9:89318473-89367117 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human SECISBP2 associations

Human Disease Mouse Models
       Thyroid Hormone Metabolism, Abnormal   OMIM: 609698
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    14 phenotypes from 3 alleles in 4 genetic backgrounds
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    19
  • Chemically induced (other)
    1
  • Gene trapped
    15
  • Targeted
    3
  • Genomic Mutations
    1 involving Secisbp2
  • Incidental Mutations
Mice homozygous for a knock-out allele exhibit complete preweaning lethality while heterozygotes exhibit reduced serum selenium levels.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000020967 VEGA Gene Model | MGI Sequence Detail 32348 C57BL/6J ±  kb
transcript OTTMUST00000049571 VEGA | MGI Sequence Detail 3328 Not Applicable  
polypeptide OTTMUSP00000022992 VEGA | MGI Sequence Detail 858 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    193 from dbSNP Build 142
Protein
Information
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  • UniProt
    3 Sequences
  • InterPro Domains
    IPR029064 50S ribosomal protein L30e-like
    IPR004038 Ribosomal protein L7Ae/L30e/S12e/Gadd45
Molecular
Reagents
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  • All nucleic 56
    cDNA 56

    Microarray probesets 5
Other
Accession IDs
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MGI:1919610
References
more
  • Summaries
    All 38
    Developmental Gene Expression 1
    Gene Ontology 6
    Phenotypes 15
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:213480 Seeher S, et al., Impaired selenoprotein expression in brain triggers striatal neuronal loss leading to co-ordination defects in mice. Biochem J. 2014 Aug 15;462(1):67-75

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory