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Secisbp2 Gene Detail
Summary
  • Symbol
    Secisbp2
  • Name
    SECIS binding protein 2
  • Synonyms
    2210413N07Rik, 2810012K13Rik, SBP2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1922670
    NCBI Gene: 75420
  • Gene Overview
    MyGene.info: SECISBP2
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:51651697-51684044 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 13, 26.12 cM, cytoband B1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    193 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1922670
protein coding gene Chr13:51650828-51684044 (.)
129S1/SvImJ MGP_129S1SvImJ_G0020552
protein coding gene Chr13:50874757-50911231 (+)
A/J MGP_AJ_G0020506
protein coding gene Chr13:49070926-49104397 (+)
AKR/J MGP_AKRJ_G0020484
protein coding gene Chr13:50465297-50497443 (+)
BALB/cJ MGP_BALBcJ_G0020502
protein coding gene Chr13:49259304-49291391 (+)
C3H/HeJ MGP_C3HHeJ_G0020301
protein coding gene Chr13:50305823-50340755 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020936
protein coding gene Chr13:52442196-52475354 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0018518
protein coding gene Chr13:46868588-46901541 (+)
CAST/EiJ MGP_CASTEiJ_G0019815
protein coding gene Chr13:50266749-50303383 (+)
CBA/J MGP_CBAJ_G0020261
protein coding gene Chr13:54473870-54509018 (+)
DBA/2J MGP_DBA2J_G0020384
protein coding gene Chr13:48638418-48671146 (+)
FVB/NJ MGP_FVBNJ_G0020363
protein coding gene Chr13:48066540-48098408 (+)
LP/J MGP_LPJ_G0020460
protein coding gene Chr13:51145100-51179779 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0020392
protein coding gene Chr13:54072015-54110919 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020979
protein coding gene Chr13:50038507-50074099 (+)
PWK/PhJ MGP_PWKPhJ_G0019572
protein coding gene Chr13:48559067-48593038 (+)
SPRET/EiJ MGP_SPRETEiJ_G0019399
protein coding gene Chr13:48925411-48962823 (+)
WSB/EiJ MGP_WSBEiJ_G0019877
protein coding gene Chr13:50347090-50378739 (+)



Homology
more
  • Human Ortholog
    SECISBP2, SECIS binding protein 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SECISBP2, SECIS binding protein 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    SBP2
  • Links
    NCBI Gene ID: 79048
    neXtProt AC: NX_Q96T21
    UniProt: Q96T21

  • Chr Location
    9q22.2; chr9:89318473-89367117 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    14 phenotypes from 3 alleles in 4 genetic backgrounds
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit complete preweaning lethality while heterozygotes exhibit reduced serum selenium levels.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000035139 Ensembl Gene Model | MGI Sequence Detail 32348 C57BL/6J ±  kb
    transcript ENSMUST00000040117 Ensembl | MGI Sequence Detail 3328 Not Applicable  
    polypeptide ENSMUSP00000045740 Ensembl | MGI Sequence Detail 858 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • InterPro Domains
      IPR029064 50S ribosomal protein L30e-like
      IPR004038 Ribosomal protein L7Ae/L30e/S12e/Gadd45
    Molecular
    Reagents
    less
    • All nucleic 57
      cDNA 57

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1919610
    References
    more
    • Summaries
      All 45
      Developmental Gene Expression 1
      Gene Ontology 8
      Phenotypes 15
    • Earliest
      J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
    • Latest
      J:251875 Fu J, et al., Thyroid Hormone Metabolism Defects in a Mouse Model of SBP2 Deficiency. Endocrinology. 2017 Dec 1;158(12):4317-4330

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory