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Dph3 Gene Detail
Summary
  • Symbol
    Dph3
  • Name
    diphthamine biosynthesis 3
  • Synonyms
    2610018L09Rik, 5730511P15Rik, DELGIP1, DESR1, KTI11, Zcsl2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1922658
    NCBI Gene: 105638
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:32080566-32085729 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 19.40 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    47 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1922658
protein coding gene Chr14:32080517-32085729 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021136
protein coding gene Chr14:25307643-25312768 (-)
A/J MGP_AJ_G0021084
protein coding gene Chr14:24343372-24348498 (-)
AKR/J MGP_AKRJ_G0021061
protein coding gene Chr14:25477760-25482886 (-)
BALB/cJ MGP_BALBcJ_G0021088
protein coding gene Chr14:24500219-24505345 (-)
C3H/HeJ MGP_C3HHeJ_G0020871
protein coding gene Chr14:25361656-25366782 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021520
protein coding gene Chr14:26306975-26312101 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019083
protein coding gene Chr14:24417217-24430635 (-)
CAST/EiJ MGP_CASTEiJ_G0020396
protein coding gene Chr14:25156223-25161327 (-)
CBA/J MGP_CBAJ_G0020838
protein coding gene Chr14:27297393-27302519 (-)
DBA/2J MGP_DBA2J_G0020960
protein coding gene Chr14:24381758-24386884 (-)
FVB/NJ MGP_FVBNJ_G0020944
protein coding gene Chr14:24337428-24342554 (-)
LP/J MGP_LPJ_G0021029
protein coding gene Chr14:25630288-25635413 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020970
protein coding gene Chr14:26539500-26544626 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021553
protein coding gene Chr14:25260227-25265353 (-)
PWK/PhJ MGP_PWKPhJ_G0020144
protein coding gene Chr14:23850473-23855742 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019968
protein coding gene Chr14:24872372-24877486 (-)
WSB/EiJ MGP_WSBEiJ_G0020451
protein coding gene Chr14:25327720-25332846 (-)



Homology
more
  • Human Ortholog
    DPH3, diphthamide biosynthesis 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    DPH3, diphthamide biosynthesis 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    DELGIP, DELGIP1, DESR1, DPH3A, KTI11, ZCSL2
  • Links
    NCBI Gene ID: 285381
    neXtProt AC: NX_Q96FX2
    UniProt: Q96FX2

  • Chr Location
    3p25.1; chr3:16257061-16264989 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 44717
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: DPH3
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    11 phenotypes from 1 allele in 1 genetic background
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mice display embryonic lethality during organogenesis, failure of chorioallantoic fusion, impaired placental development, and embryonic growth retardation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000021905 Ensembl Gene Model | MGI Sequence Detail 5164 C57BL/6J ±  kb
transcript ENSMUST00000022461 Ensembl | MGI Sequence Detail 1057 Not Applicable  
polypeptide ENSMUSP00000022461 Ensembl | MGI Sequence Detail 82 Not Applicable  
For the selected sequence
Protein
Information
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Molecular
Reagents
less
  • All nucleic 77
    cDNA 77

    Microarray probesets 5
Other
Accession IDs
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MGI:1917878, MGI:2145713, MGI:2145777
References
more
  • Summaries
    All 32
    Gene Ontology 3
    Phenotypes 6
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:239017 Steinmetz CC, et al., Upregulation of mu3A Drives Homeostatic Plasticity by Rerouting AMPAR into the Recycling Endosomal Pathway. Cell Rep. 2016 Sep 06;16(10):2711-22

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
03/19/2019
MGI 6.13
The Jackson Laboratory