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Dph3 Gene Detail
Summary
  • Symbol
    Dph3
  • Name
    diphthamine biosynthesis 3
  • Synonyms
    2610018L09Rik, 5730511P15Rik, DELGIP1, DESR1, KTI11, Zcsl2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1922658
    NCBI Gene: 105638
Location & Maps
more
  • Sequence Map
    Chr14:32080566-32085692 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      5127 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 19.40 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    DPH3, diphthamide biosynthesis 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    DPH3, diphthamide biosynthesis 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    DELGIP, DELGIP1, DESR1, DPH3A, KTI11, ZCSL2
  • Links
    NCBI Gene ID: 285381
    neXtProt AC: NX_Q96FX2

  • Chr Location
    3p25.1; chr3:16257061-16264989 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 44717
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: DPH3
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    11 phenotypes from 1 allele in 1 genetic background
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    18
  • Gene trapped
    13
  • Targeted
    5
  • Incidental Mutations
    APF
Homozygous null mice display embryonic lethality during organogenesis, failure of chorioallantoic fusion, impaired placental development, and embryonic growth retardation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000019770 VEGA Gene Model | MGI Sequence Detail 5127 C57BL/6J ±  kb
transcript OTTMUST00000047285 VEGA | MGI Sequence Detail 1057 Not Applicable  
polypeptide OTTMUSP00000021341 VEGA | MGI Sequence Detail 82 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    47 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
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  • All nucleic 76
    cDNA 76

    Microarray probesets 5
Other
Accession IDs
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MGI:1917878, MGI:2145713, MGI:2145777
References
more
  • Summaries
    All 30
    Gene Ontology 2
    Phenotypes 6
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory