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Arhgap24 Gene Detail
Summary
  • Symbol
    Arhgap24
  • Name
    Rho GTPase activating protein 24
  • Synonyms
    0610025G21Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1922647
    NCBI Gene: 231532
  • Gene Overview
    MyGene.info: ARHGAP24
Location & Maps
more
  • Sequence Map
    Chr5:102481391-102897937 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      416547 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    ARHGAP24, Rho GTPase activating protein 24
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ARHGAP24, Rho GTPase activating protein 24
    Orthology source: HomoloGene
  • Synonyms
    FILGAP, p73, p73RhoGAP, RCGAP72, RC-GAP72
  • Links
    NCBI Gene ID: 83478
    neXtProt AC: NX_Q8N264

  • Chr Location
    4q22.1; chr4:85147742-86002670 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    7
  • Chemically induced (other)
    1
  • Gene trapped
    1
  • Radiation induced
    1
  • Spontaneous
    1
  • Targeted
    3
  • Genomic Mutations
    3 involving Arhgap24
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023079 VEGA Gene Model | MGI Sequence Detail 416547 C57BL/6J ±  kb
transcript OTTMUST00000055707 VEGA | MGI Sequence Detail 3346 Not Applicable  
polypeptide OTTMUSP00000026714 VEGA | MGI Sequence Detail 747 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    4810 from dbSNP Build 142
Protein
Information
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  • UniProt
    5 Sequences
  • Protein Ontology
    PR:000004230 rho GTPase-activating protein 24
  • InterPro Domains
    IPR011993 PH domain-like
    IPR001849 Pleckstrin homology domain
    IPR000198 Rho GTPase-activating protein domain
    IPR008936 Rho GTPase activation protein
Molecular
Reagents
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  • All nucleic 12
    cDNA 12

    Microarray probesets 4
References
more
  • Summaries
    All 30
    Developmental Gene Expression 5
    Gene Ontology 3
    Phenotypes 12
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:178221 Akilesh S, et al., Arhgap24 inactivates Rac1 in mouse podocytes, and a mutant form is associated with familial focal segmental glomerulosclerosis. J Clin Invest. 2011 Oct 3;121(10):4127-37

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory