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Slamf7
Gene Detail
Symbol

Name
ID
Slamf7
SLAM family member 7
MGI:1922595
Synonyms
19A, 19A24, 4930560D03Rik, CS1, novel Ly9
Feature Type
protein coding gene
Genetic Map
Chromosome 1
79.54 cM, cytoband H2
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr1:171634925-171649007 bp, - strand
From Ensembl annotation of GRCm38

  14083 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:49660  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Gene Tree: Slamf7

Human
homologs
Human Homolog SLAMF7, SLAM family member 7
NCBI Gene ID 57823
neXtProt AC  NX_Q9NQ25
Human Synonyms  19A, CD319, CRACC, CS1
Human Chr (Location)  1q23.1-q24.1; chr1:160739057-160754821 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Natural Killer cells from null homozygotes display impaired cytolysis of certain target cells.
 
Interactions
Slamf7 interacts with 55 markers (Mir19a, Mir19b-1, Mir19b-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (8 annotations)
Process regulation of natural killer cell activation
Component external side of plasma membrane, integral component of membrane, ...
Function protein binding, receptor activity
External Resources: FuncBase
Expression
cDNA source data(20)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(21) Genomic(1) cDNA(20)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000038179 (Evidence)
Entrez Gene75345 (Evidence)
UniGene164642
DFCITC1584237, TC1593064, TC1596101
DoTSDT.101364867, DT.99856922, DT.99845553, DT.97356853, DT.99856925
NIA Mouse Gene IndexU022059
Consensus CDS ProjectCCDS15500.1
International Mouse Knockout Project StatusSlamf7
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000038179 Ensembl Gene Model | MGI Sequence Detail 14083 C57BL/6J ±  kb
transcript ENSMUST00000111276 Ensembl | MGI Sequence Detail 1082 Not Applicable 
polypeptide ENSMUSP00000106907 Ensembl | MGI Sequence Detail 333 Not Applicable 

For the selected sequences
All sequences(49) RefSeq(12) UniProt(7)
Polymorphisms
SNPs within 2kb(232 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR015631 Signalling lymphocyte activation molecule family receptors
Protein Ontology PR:000001834 SLAM family member 7
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:194395 Dongre P, et al., YY1 and a unique DNA repeat element regulates the transcription of mouse CS1 (CD319, SLAMF7) gene. Mol Immunol. 2013 Jul;54(3-4):254-63
All references(35)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory