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Parpbp Gene Detail
Summary
  • Symbol
    Parpbp
  • Name
    PARP1 binding protein
  • Synonyms
    4930547N16Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1922567
    NCBI Gene: 75317
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:88091432-88146941 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 43.70 cM, cytoband C2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    482 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1922567
protein coding gene Chr10:88091398-88146946 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017622
protein coding gene Chr10:89160303-89214960 (-)
A/J MGP_AJ_G0017601
protein coding gene Chr10:86159420-86207150 (-)
AKR/J MGP_AKRJ_G0017559
protein coding gene Chr10:88604900-88657441 (-)
BALB/cJ MGP_BALBcJ_G0017564
protein coding gene Chr10:86437279-86486873 (-)
C3H/HeJ MGP_C3HHeJ_G0017387
protein coding gene Chr10:88588440-88637060 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018021
protein coding gene Chr10:92153612-92211132 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015703
protein coding gene Chr10:81921947-81968673 (-)
CAST/EiJ MGP_CASTEiJ_G0016952
protein coding gene Chr10:88485530-88539960 (-)
CBA/J MGP_CBAJ_G0017356
protein coding gene Chr10:95975419-96034818 (-)
DBA/2J MGP_DBA2J_G0017462
protein coding gene Chr10:85277651-85325135 (-)
FVB/NJ MGP_FVBNJ_G0017454
protein coding gene Chr10:84505011-84552613 (-)
LP/J MGP_LPJ_G0017536
protein coding gene Chr10:89837613-89890673 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017485
protein coding gene Chr10:97491478-97546274 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018058
protein coding gene Chr10:88440918-88488461 (-)
PWK/PhJ MGP_PWKPhJ_G0016733
protein coding gene Chr10:85284965-85333832 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016520
protein coding gene Chr10:87172487-87221716 (-)
WSB/EiJ MGP_WSBEiJ_G0017011
protein coding gene Chr10:88399795-88459595 (-)



Homology
more
  • Human Ortholog
    PARPBP, PARP1 binding protein
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PARPBP, PARP1 binding protein
    Orthology source: HomoloGene, HGNC
  • Synonyms
    AROM, C12orf48, PARI
  • Links
    NCBI Gene ID: 55010
    neXtProt AC: NX_Q9NWS1
    UniProt: Q9NWS1

  • Chr Location
    12q23.2; chr12:102120171-102197520 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 49519
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: PARPBP
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotype references
  • All Mutations and Alleles
    10
  • Chemically induced (other)
    1
  • Gene trapped
    3
  • Targeted
    6
  • Genomic Mutations
    1 involving Parpbp
  • Incidental Mutations
    APF
  • Find Mice (IMSR)
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000035365 Ensembl Gene Model | MGI Sequence Detail 55510 C57BL/6J ±  kb
transcript ENSMUST00000048518 Ensembl | MGI Sequence Detail 3594 Not Applicable  
polypeptide ENSMUSP00000038375 Ensembl | MGI Sequence Detail 573 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    5 Sequences
  • InterPro Domains
    IPR038932 PCNA-interacting partner
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
Molecular
Reagents
less
  • All nucleic 27
    cDNA 27

    Microarray probesets 4
Other
Accession IDs
less
MGI:2143631
References
more
  • Summaries
    All 40
    Developmental Gene Expression 2
    Gene Ontology 2
    Phenotypes 13
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:248791 Mochizuki AL, et al., PARI Regulates Stalled Replication Fork Processing To Maintain Genome Stability upon Replication Stress in Mice. Mol Cell Biol. 2017 Dec 1;37(23)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
03/13/2019
MGI 6.13
The Jackson Laboratory