Prkd3
Gene Detail

Symbol Name ID

Prkd3 protein kinase D3 MGI:1922542

Synonyms

4930557O20Rik, 5730497N19Rik, MGC:47171, PKD3, Prkcn

Feature Type

protein coding gene

Genetic Map

Chromosome 17

49.69 cM, cytoband E3
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr17:78949405-79020816 bp, - strand From VEGA annotation of GRCm38   71412 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cattle; chimpanzee; dog, domestic    (Mammalian Orthology)
Comparative Map (Mouse/Human Prkd3 ± 2 cM)

Protein SuperFamily: protein kinase C, mu/nu/D2 types
Gene Tree: Prkd3

Human ortholog

PRKD3 protein kinase D3 NCBI Gene ID 23683
Human Synonyms: EPK2, nPKC-NU, PKC-NU, PKD3, PRKCN
Human Chr2:37477645-37544222 bp, - strand Reference GRCh37.p2 Primary Assembly

Alleles and phenotypes

All alleles(22) : Targeted(2) Gene trapped(20)
 

Homozygous mutation of this gene results in abnormal vertebral trabecular bone morphology and abnormal femur morphology.

 

Gene Ontology (GO) classifications

All GO classifications: (19 annotations)

Process	intracellular signal transduction, phosphorylation, ...
Component	cytoplasm, membrane
Function	ATP binding, identical protein binding, ...

External Resources: FuncBase

Expression

Literature Summary: (4 records)
Data Summary: Results (158)    Tissues (134)    Images (37)
Theiler Stages: 13, 15, 17, 20, 22, 24, 26, 28

Assay Type	Results
RNA in situ	154
RT-PCR	4

cDNA source data(15)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(19) cDNA(18) Primer pair(1)
Microarray probesets(7)

Other database links

VEGA Gene Model	OTTMUSG00000031058 (Evidence)
Ensembl Gene Model	ENSMUSG00000024070 (Evidence)
Entrez Gene	75292 (Evidence)
DFCI	TC1574636, TC1607231, TC1658827, TC1707040
DoTS	DT.101144866, DT.102547230, DT.103573944, DT.488093, DT.60103455, DT.91425841, DT.91430635
NIA Mouse Gene Index	U038073
EC	2.7.11.13
Consensus CDS Project	CCDS37699.1, CCDS50184.1, CCDS50185.1
International Mouse Knockout Project Status	Prkd3

Sequences

Length	Strain/Species
genomic	OTTMUSG00000031058	VEGA Gene Model | MGI Sequence Detail	71412	C57BL/6J
transcript	OTTMUST00000077141	VEGA | MGI Sequence Detail	4743	Not Applicable
polypeptide	OTTMUSP00000040724	VEGA | MGI Sequence Detail	890	Not Applicable

All sequences(69) RefSeq(6) UniProt(5)

Polymorphisms

SNPs(500 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR020454	Diacylglycerol/phorbol-ester binding
InterPro	IPR001849	Pleckstrin homology domain
InterPro	IPR011993	Pleckstrin homology-like domain
InterPro	IPR017441	Protein kinase, ATP binding site
InterPro	IPR000719	Protein kinase, catalytic domain
InterPro	IPR002219	Protein kinase C-like, phorbol ester/diacylglycerol binding
InterPro	IPR015727	Protein kinase C mu-related
InterPro	IPR011009	Protein kinase-like domain
InterPro	IPR002290	Serine/threonine- / dual-specificity protein kinase, catalytic domain
InterPro	IPR008271	Serine/threonine-protein kinase, active site
Protein Ontology	PR:000013238	serine/threonine-protein kinase D3

References

(Earliest) J:120490 Morrow TA, et al., Pro-B-cell-specific transcription and proapoptotic function of protein kinase Ceta. Mol Cell Biol. 1999 Aug;19(8):5608-18
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(42)

Other accession IDs

MGI:1917857