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Prkd3 Gene Detail
Summary
  • Symbol
    Prkd3
  • Name
    protein kinase D3
  • Synonyms
    4930557O20Rik, 5730497N19Rik, MGC:47171, PKD3, Prkcn
  • Feature Type
    protein coding gene
  • IDs
    MGI:1922542
    NCBI Gene: 75292
  • Gene Overview
    MyGene.info: PRKD3
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:78949405-79020816 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 49.69 cM, cytoband E3
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    855 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1922542
protein coding gene Chr17:78949405-79020816 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024048
protein coding gene Chr17:81791100-81865690 (-)
A/J MGP_AJ_G0024005
protein coding gene Chr17:79288739-79361002 (-)
AKR/J MGP_AKRJ_G0023974
protein coding gene Chr17:80493742-80564665 (-)
BALB/cJ MGP_BALBcJ_G0024007
protein coding gene Chr17:79157171-79228343 (-)
C3H/HeJ MGP_C3HHeJ_G0023771
protein coding gene Chr17:81397408-81469256 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024451
protein coding gene Chr17:84771727-84856580 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021893
protein coding gene Chr17:74686618-74757928 (-)
CAST/EiJ MGP_CASTEiJ_G0023251
protein coding gene Chr17:82000301-82079482 (-)
CBA/J MGP_CBAJ_G0023745
protein coding gene Chr17:88305295-88384763 (-)
DBA/2J MGP_DBA2J_G0023874
protein coding gene Chr17:77804370-77876248 (-)
FVB/NJ MGP_FVBNJ_G0023840
protein coding gene Chr17:77323967-77395378 (-)
LP/J MGP_LPJ_G0023957
protein coding gene Chr17:82646714-82722705 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023868
protein coding gene Chr17:88426560-88500596 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024496
protein coding gene Chr17:80969829-81045233 (-)
PWK/PhJ MGP_PWKPhJ_G0022997
protein coding gene Chr17:77302063-77374848 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022808
protein coding gene Chr17:77754685-77828432 (-)
WSB/EiJ MGP_WSBEiJ_G0023318
protein coding gene Chr17:81787531-81864748 (-)



Homology
more
  • Human Ortholog
    PRKD3, protein kinase D3
  • Vertebrate Orthologs
    9
  • Human Ortholog
    PRKD3, protein kinase D3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    EPK2, nPKC-NU, PKC-NU, PKD3, PRKCN
  • Links
    NCBI Gene ID: 23683
    neXtProt AC: NX_O94806
    UniProt: O94806

  • Chr Location
    2p22.2; chr2:37250502-37324803 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    3 phenotypes from multigenic genotypes
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in abnormal vertebral trabecular bone morphology and abnormal femur morphology.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic 75292 NCBI Gene Model | MGI Sequence Detail 71412 C57BL/6J ±  kb
    transcript NM_001171004 RefSeq | MGI Sequence Detail 5887 C57BL/6  
    polypeptide Q8K1Y2 UniProt | EBI | MGI Sequence Detail 889 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • EC
    • InterPro Domains
      IPR020454 Diacylglycerol/phorbol-ester binding
      IPR011993 PH-like domain superfamily
      IPR001849 Pleckstrin homology domain
      IPR017441 Protein kinase, ATP binding site
      IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
      IPR015727 Protein kinase C mu-related
      IPR000719 Protein kinase domain
      IPR011009 Protein kinase-like domain superfamily
      IPR008271 Serine/threonine-protein kinase, active site
    Molecular
    Reagents
    less
    • All nucleic 21
      cDNA 20
      Primer pair 1

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:1917857
    References
    more
    • Summaries
      All 43
      Developmental Gene Expression 4
      Gene Ontology 6
      Phenotypes 9
    • Earliest
      J:120490 Morrow TA, et al., Pro-B-cell-specific transcription and proapoptotic function of protein kinase Ceta. Mol Cell Biol. 1999 Aug;19(8):5608-18
    • Latest
      J:236298 Ishikawa E, et al., Protein kinase D regulates positive selection of CD4+ thymocytes through phosphorylation of SHP-1. Nat Commun. 2016 Sep 27;7:12756

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory