About   Help   FAQ
Prkd3 Gene Detail
Summary
  • Symbol
    Prkd3
  • Name
    protein kinase D3
  • Synonyms
    4930557O20Rik, 5730497N19Rik, MGC:47171, PKD3, Prkcn
  • Feature Type
    protein coding gene
  • IDs
    MGI:1922542
    NCBI Gene: 75292
Location & Maps
more
  • Sequence Map
    Chr17:78949405-79020816 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      71412 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    PRKD3, protein kinase D3
  • Vertebrate Orthologs
    9
  • Human Ortholog
    PRKD3, protein kinase D3
    Orthology source: HomoloGene
  • Synonyms
    EPK2, nPKC-NU, PKC-NU, PKD3, PRKCN
  • Links
    NCBI Gene ID: 23683
    neXtProt AC: NX_O94806

  • Chr Location
    2p21; chr2:37250502-37324772 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in abnormal vertebral trabecular bone morphology and abnormal femur morphology.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000031058 VEGA Gene Model | MGI Sequence Detail 71412 C57BL/6J ±  kb
transcript OTTMUST00000077141 VEGA | MGI Sequence Detail 4743 Not Applicable  
polypeptide OTTMUSP00000040724 VEGA | MGI Sequence Detail 890 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    879 from dbSNP Build 137
Protein
Information
less
  • UniProt
    5 Sequences
  • Protein Ontology
    PR:000013238 serine/threonine-protein kinase D3
  • EC
  • InterPro Domains
    IPR020454 Diacylglycerol/phorbol-ester binding
    IPR011993 PH domain-like
    IPR001849 Pleckstrin homology domain
    IPR017441 Protein kinase, ATP binding site
    IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
    IPR015727 Protein kinase C mu-related
    IPR000719 Protein kinase domain
    IPR011009 Protein kinase-like domain
    IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
    IPR008271 Serine/threonine-protein kinase, active site
Molecular
Reagents
less
  • All nucleic 19
    cDNA 18
    Primer pair 1

    Microarray probesets 7
Other
Accession IDs
less
MGI:1917857
References
more
  • Summaries
    All 38
    Developmental Gene Expression 4
    Gene Ontology 4
    Phenotypes 7
  • Earliest
    J:120490 Morrow TA, et al., Pro-B-cell-specific transcription and proapoptotic function of protein kinase Ceta. Mol Cell Biol. 1999 Aug;19(8):5608-18
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
02/02/2016
MGI 6.02
The Jackson Laboratory