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Prkd3
Gene Detail
Symbol

Name
ID
Prkd3
protein kinase D3
MGI:1922542
Synonyms
4930557O20Rik, 5730497N19Rik, MGC:47171, PKD3, Prkcn
Feature Type
protein coding gene
Genetic Map
Chromosome 17
49.69 cM, cytoband E3
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr17:78949405-79020816 bp, - strand
From VEGA annotation of GRCm38

  71412 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2055  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: protein kinase C, mu/nu/D2 types
Gene Tree: Prkd3

Human
homologs
Human Homolog PRKD3, protein kinase D3
NCBI Gene ID 23683
neXtProt AC  NX_O94806
Human Synonyms  EPK2, nPKC-NU, PKC-NU, PKD3, PRKCN
Human Chr (Location)  2p21; chr2:37250502-37324772 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(22) : Gene trapped(20) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutation of this gene results in abnormal vertebral trabecular bone morphology and abnormal femur morphology.
 
Interactions
Prkd3 interacts with 350 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process intracellular signal transduction, phosphorylation, ...
Component cytoplasm, membrane, ...
Function ATP binding, kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (158)    Tissues (135)    Images (37)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 154
RT-PCR 4
cDNA source data(15)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(19) cDNA(18) Primer pair(1)
Microarray probesets(7)
Other database
links
VEGA Gene ModelOTTMUSG00000031058 (Evidence)
Ensembl Gene ModelENSMUSG00000024070 (Evidence)
Entrez Gene75292 (Evidence)
DFCITC1574636, TC1607231, TC1658827, TC1707040
DoTSDT.101144866, DT.102547230, DT.103573944, DT.488093, DT.60103455, DT.91425841, DT.91430635
NIA Mouse Gene IndexU038073
EC2.7.11.13
Consensus CDS ProjectCCDS37699.1, CCDS50184.1, CCDS50185.1
International Mouse Knockout Project StatusPrkd3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000031058 VEGA Gene Model | MGI Sequence Detail 71412 C57BL/6J ±  kb
transcript OTTMUST00000077141 VEGA | MGI Sequence Detail 4743 Not Applicable 
polypeptide OTTMUSP00000040724 VEGA | MGI Sequence Detail 890 Not Applicable 

For the selected sequences
All sequences(71) RefSeq(8) UniProt(5)
Polymorphisms
SNPs within 2kb(879 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR020454 Diacylglycerol/phorbol-ester binding
InterPro IPR001849 Pleckstrin homology domain
InterPro IPR011993 Pleckstrin homology-like domain
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol binding
InterPro IPR015727 Protein kinase C mu-related
InterPro IPR011009 Protein kinase-like domain
InterPro IPR002290 Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
Protein Ontology PR:000013238 serine/threonine-protein kinase D3
References
(Earliest) J:120490 Morrow TA, et al., Pro-B-cell-specific transcription and proapoptotic function of protein kinase Ceta. Mol Cell Biol. 1999 Aug;19(8):5608-18
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(42)
Other
accession IDs
MGI:1917857

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory