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Dpp3 Gene Detail
Summary
  • Symbol
    Dpp3
  • Name
    dipeptidylpeptidase 3
  • Synonyms
    4930533O14Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1922471
    NCBI Gene: 75221
  • Gene Overview
    MyGene.info: DPP3
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:4957257-4978315 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 19, 4.15 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    121 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1922471
protein coding gene Chr19:4957257-4978315 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024681
protein coding gene Chr19:1818239-1840876 (-)
A/J MGP_AJ_G0024647
protein coding gene Chr19:1726170-1747012 (-)
AKR/J MGP_AKRJ_G0024620
protein coding gene Chr19:1772466-1793308 (-)
BALB/cJ MGP_BALBcJ_G0024647
protein coding gene Chr19:1719780-1740622 (-)
C3H/HeJ MGP_C3HHeJ_G0024415
protein coding gene Chr19:1774991-1795833 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025094
protein coding gene Chr19:1871139-1897154 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022524
protein coding gene Chr19:1657271-1681333 (-)
CAST/EiJ MGP_CASTEiJ_G0023887
protein coding gene Chr19:1805058-1825955 (-)
CBA/J MGP_CBAJ_G0024386
protein coding gene Chr19:1951841-1972692 (-)
DBA/2J MGP_DBA2J_G0024514
protein coding gene Chr19:1692945-1713801 (-)
FVB/NJ MGP_FVBNJ_G0024481
protein coding gene Chr19:1715531-1736393 (-)
LP/J MGP_LPJ_G0024600
protein coding gene Chr19:1820597-1842913 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024511
protein coding gene Chr19:1846088-1866815 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025142
protein coding gene Chr19:1770221-1791607 (-)
PWK/PhJ MGP_PWKPhJ_G0023633
protein coding gene Chr19:1742859-1765648 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023438
protein coding gene Chr19:1757157-1778354 (-)
WSB/EiJ MGP_WSBEiJ_G0023949
protein coding gene Chr19:1775006-1795866 (-)



Homology
more
  • Human Ortholog
    DPP3, dipeptidyl peptidase 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DPP3, dipeptidyl peptidase 3
  • Synonyms
    DPPIII
  • Links
    NCBI Gene ID: 10072
    neXtProt AC: NX_Q9NY33
    UniProt: Q9NY33

  • Chr Location
    11q13.2; chr11:66480013-66509659 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    22 phenotypes from 2 alleles in 2 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous knockout results in increased bone resorption or decalcification, causing bone loss in 6 months old mice.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • cDNA Data
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 75221 NCBI Gene Model | MGI Sequence Detail 21059 C57BL/6J ±  kb
    transcript NM_133803 RefSeq | MGI Sequence Detail 2683 C57BL/6  
    polypeptide Q99KK7 UniProt | EBI | MGI Sequence Detail 738 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 204
      cDNA 204

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2147803
    References
    more
    • Summaries
      All 35
      Gene Ontology 5
      Phenotypes 12
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:298564 Jha S, et al., Dipeptidyl peptidase 3 modulates the renin-angiotensin system in mice. J Biol Chem. 2020 Oct 2;295(40):13711-13723

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    last database update
    09/07/2021
    MGI 6.17
    The Jackson Laboratory