Sv2c Gene Detail

Summary

• Symbol
  Sv2c
• Name
  synaptic vesicle glycoprotein 2c
• Synonyms
  4930527L09Rik

• Feature Type
  protein coding gene
• IDs
  MGI:1922459
  NCBI Gene: 75209
• Alliance
  gene page
• Transcription Start Sites
  5 TSS

Location &
Maps

• Sequence Map
  Chr13:95959443-96132577 bp, - strand
• From NCBI annotation of GRCm38
  

  View this region in JBrowse
  
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 13, 50.47 cM, cytoband D1
• Mapping Data
  3 experiments

Strain
Comparison

• SNPs within 2kb
  2236 from dbSNP Build 142
• Strain Annotations
  18

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1922459	protein coding gene	Chr13:95954594-96132577 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0020846	protein coding gene	Chr13:97456301-97640404 (-)
A/J	MGP_AJ_G0020800	protein coding gene	Chr13:93797292-93974190 (-)
AKR/J	MGP_AKRJ_G0020774	protein coding gene	Chr13:96660802-96850924 (-)
BALB/cJ	MGP_BALBcJ_G0020797	protein coding gene	Chr13:94476487-94656463 (-)
C3H/HeJ	MGP_C3HHeJ_G0020590	protein coding gene	Chr13:96354073-96540907 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0021233	protein coding gene	Chr13:100407054-100610992 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018802	protein coding gene	Chr13:89609917-89790573 (-)
CAST/EiJ	MGP_CASTEiJ_G0020109	protein coding gene	Chr13:95661903-95849576 (-)
CBA/J	MGP_CBAJ_G0020549	protein coding gene	Chr13:104386763-104580101 (-)
DBA/2J	MGP_DBA2J_G0020674	protein coding gene	Chr13:93572140-93752801 (-)
FVB/NJ	MGP_FVBNJ_G0020655	protein coding gene	Chr13:92353555-92532315 (-)
LP/J	MGP_LPJ_G0020749	protein coding gene	Chr13:97573048-97777973 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020683	protein coding gene	Chr13:104815934-105007110 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021273	protein coding gene	Chr13:96064797-96261572 (-)
PWK/PhJ	MGP_PWKPhJ_G0019861	protein coding gene	Chr13:92357099-92540291 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0019685	protein coding gene	Chr13:92350362-92543403 (-)
WSB/EiJ	MGP_WSBEiJ_G0020166	protein coding gene	Chr13:96563108-96749016 (-)

Homology

• Human Ortholog
  SV2C, synaptic vesicle glycoprotein 2C

• Vertebrate Orthologs
  10

• Human Ortholog
  SV2C, synaptic vesicle glycoprotein 2C
  Orthology source: HomoloGene, HGNC
• Links
  HGNC:30670

  NCBI Gene ID: 22987

  neXtProt AC: NX_Q496J9

  UniProt: Q496J9

  
  
• Chr Location
  5q13.3; chr5:75847463-76353939 (+)  GRCh38.p7

---

• HomoloGene
  Vertebrate Homology Class 57152
  1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  
• HCOP
  human homology predictions: SV2C
• Protein SuperFamily
  synaptic vesicle protein SV2
• Gene Tree
  Sv2c
  

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  3 phenotypes from 1 allele in 1 genetic background
  11 phenotype references
  

• All Mutations and Alleles
  9
• Gene trapped
  3
• Targeted
  6
• Incidental Mutations
  Mutagenetix , APF , CvDC
• Find Mice (IMSR)
  6 strains or lines available

Mice homozygous for a knock-out allele exhibit hypoactivity and increased anxiety-related response.

Gene Ontology
(GO)
Classifications

• All GO Annotations
  16
• GO References
  5

• External Resources
  FuncBase

Expression

• Assay Results
  759
• Tissues
  112
• cDNA Data
  7
• Literature Summary
  13

Images

Tissue x Stage Matrix

• Other Mouse Links
  Allen Institute
  GEO
  Expression Atlas

Interactions

• Sv2c interacts with 250 markers (Mir9-1, Mir9-2, Mir9-3, ...) View All

Sequences &
Gene Models

• All Sequences
  40
• RefSeq
  4
• UniProt
  3
• CCDS
  CCDS49333.1

• Ensembl
  ENSMUSG00000051111 (Evidence)
• NCBI Gene
  75209

Representative Sequences			Length	Strain/Species
genomic	75209	NCBI Gene Model | MGI Sequence Detail	173135	C57BL/6J
transcript	NM_029210	RefSeq | MGI Sequence Detail	4252	C57BL/6
polypeptide	Q69ZS6	UniProt | EBI | MGI Sequence Detail	727	Not Applicable

Protein
Information

• UniProt
  3 Sequences
• Protein Ontology
  PR:000015851 synaptic vesicle glycoprotein 2C
  (term hierarchy)
• InterPro Domains
  IPR005828 Major facilitator, sugar transporter-like
  IPR011701 Major facilitator superfamily
  IPR020846 Major facilitator superfamily domain
  IPR036259 MFS transporter superfamily
  IPR001646 Pentapeptide repeat
  IPR005829 Sugar transporter, conserved site
  IPR022308 Synaptic vesicle protein SV2

Molecular
Reagents

• All nucleic 8

  cDNA 7

  Primer pair 1

  
  

  Microarray probesets 3

Other
Accession IDs

MGI:2145291

References

• Summaries
  All 51

  Developmental Gene Expression 13

  Gene Ontology 5

  Phenotypes 11
• Earliest
  J:36947 Ahnert-Hilger G, et al., Synaptobrevin is essential for secretion but not for the development of synaptic processes. Eur J Cell Biol. 1996 May;70(1):1-11
• Latest
  J:260349 Dunn AR, et al., Immunochemical analysis of the expression of SV2C in mouse, macaque and human brain. Brain Res. 2017 Dec 21;

TSS for Sv2c:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr123558	Chr13:96132700-96132711 (-)	-129 bp
Tssr123557	Chr13:96132669-96132687 (-)	-101 bp
Tssr123556	Chr13:96132568-96132628 (-)	-21 bp
Tssr123555	Chr13:96132543-96132567 (-)	22 bp
Tssr123554	Chr13:96132521-96132530 (-)	51 bp