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Spaca6 Gene Detail
Summary
  • Symbol
    Spaca6
  • Name
    sperm acrosome associated 6
  • Synonyms
    4930546H06Rik, B230206P06Rik, Ncrna00085
  • Feature Type
    protein coding gene
  • IDs
    MGI:1922452
    NCBI Gene: 75202
  • Alliance
  • Transcription Start Sites
    14 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:18047420-18063271 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 17, 10.50 cM, cytoband A3.1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    83 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1922452
protein coding gene Chr17:18045955-18063274 (+)
129S1/SvImJ MGP_129S1SvImJ_G0023184
protein coding gene Chr17:15836808-15849437 (+)
A/J MGP_AJ_G0023149
protein coding gene Chr17:15482312-15494618 (+)
AKR/J MGP_AKRJ_G0023119
protein coding gene Chr17:15557944-15570272 (+)
BALB/cJ MGP_BALBcJ_G0023149
protein coding gene Chr17:15427764-15440087 (+)
C3H/HeJ MGP_C3HHeJ_G0022909
protein coding gene Chr17:15774418-15786727 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023592
protein coding gene Chr17:16624291-16636581 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021104
protein coding gene Chr17:13331162-13341785 (+)
CAST/EiJ MGP_CASTEiJ_G0022428
protein coding gene Chr17:15585531-15597875 (+)
CBA/J MGP_CBAJ_G0022886
protein coding gene Chr17:17193172-17205482 (+)
DBA/2J MGP_DBA2J_G0023019
protein coding gene Chr17:15196655-15208970 (+)
FVB/NJ MGP_FVBNJ_G0022987
protein coding gene Chr17:15007259-15019690 (+)
LP/J MGP_LPJ_G0023093
protein coding gene Chr17:15830999-15843316 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023008
protein coding gene Chr17:16776730-16790065 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023629
protein coding gene Chr17:15744595-15756913 (+)
PWK/PhJ MGP_PWKPhJ_G0022177
protein coding gene Chr17:14828335-14840852 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022005
protein coding gene Chr17:14831177-14843391 (+)
WSB/EiJ MGP_WSBEiJ_G0022487
protein coding gene Chr17:16033575-16045922 (+)



Homology
more
  • Human Ortholog
    SPACA6, sperm acrosome associated 6
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SPACA6, sperm acrosome associated 6
  • Synonyms
    LET7EH, LINC00085, NCRNA00085, SPACA6P
  • Links
    NCBI Gene ID: 147650
    neXtProt AC: NX_W5XKT8
    UniProt: W5XKT8

  • Chr Location
    19q13.41; chr19:51682686-51713143 (+)  GRCh38

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 3 alleles in 3 genetic backgrounds
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a transgene insertion that inactivates this gene exhibit impaired fertilization and male infertility. Mice homozygous for a null allele show male infertility due to inability of spermatozoa to fuse with the oocyte membrane.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • cDNA Data
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000080316 Ensembl Gene Model | MGI Sequence Detail 15852 C57BL/6J ±  kb
    transcript ENSMUST00000172097 Ensembl | MGI Sequence Detail 1073 Not Applicable  
    polypeptide ENSMUSP00000128732 Ensembl | MGI Sequence Detail 339 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 19
      cDNA 19

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1926095
    References
    more
    • Summaries
      All 34
      Gene Ontology 5
      Phenotypes 11
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:337404 Matsumura T, et al., Sperm IZUMO1 Is Required for Binding Preceding Fusion With Oolemma in Mice and Rats. Front Cell Dev Biol. 2021;9:810118

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    last database update
    03/19/2024
    MGI 6.23
    The Jackson Laboratory