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Rasd2 Gene Detail
Summary
  • Symbol
    Rasd2
  • Name
    RASD family, member 2
  • Synonyms
    4930526B11Rik, Rhes, TEM2, TEM-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1922391
    NCBI Gene: 75141
  • Gene Overview
    MyGene.info: RASD2
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:75213944-75224113 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 35.61 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    68 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1922391
protein coding gene Chr8:75213944-75224113 (.)
129S1/SvImJ MGP_129S1SvImJ_G0033797
protein coding gene Chr8:75663870-75674106 (+)
A/J MGP_AJ_G0033779
protein coding gene Chr8:72693205-72703492 (+)
AKR/J MGP_AKRJ_G0033706
protein coding gene Chr8:74910882-74920988 (+)
BALB/cJ MGP_BALBcJ_G0033773
protein coding gene Chr8:72786102-72796442 (+)
C3H/HeJ MGP_C3HHeJ_G0033482
protein coding gene Chr8:75475168-75485443 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034293
protein coding gene Chr8:78595366-78610735 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031234
protein coding gene Chr8:66955877-66965868 (+)
CAST/EiJ MGP_CASTEiJ_G0032811
protein coding gene Chr8:74748424-74762514 (+)
CBA/J MGP_CBAJ_G0033461
protein coding gene Chr8:81363680-81373896 (+)
DBA/2J MGP_DBA2J_G0033615
protein coding gene Chr8:72379100-72389332 (+)
FVB/NJ MGP_FVBNJ_G0033560
protein coding gene Chr8:71453683-71463606 (+)
LP/J MGP_LPJ_G0033704
protein coding gene Chr8:75797456-75807667 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033603
protein coding gene Chr8:83912178-83922410 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034310
protein coding gene Chr8:74871060-74881299 (+)
PWK/PhJ MGP_PWKPhJ_G0032517
protein coding gene Chr8:71648280-71658558 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032355
protein coding gene Chr8:73753585-73768781 (+)
WSB/EiJ MGP_WSBEiJ_G0032926
protein coding gene Chr8:75190401-75200623 (+)



Homology
more
  • Human Ortholog
    RASD2, RASD family member 2
  • Vertebrate Orthologs
    8
  • Human Ortholog
    RASD2, RASD family member 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    Rhes, TEM2
  • Links
    NCBI Gene ID: 23551
    neXtProt AC: NX_Q96D21
    UniProt: Q96D21

  • Chr Location
    22q12.3; chr22:35540492-35554003 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    4
  • Chemically induced (other)
    1
  • Gene trapped
    1
  • Targeted
    2
  • Genomic Mutations
    1 involving Rasd2
  • Incidental Mutations
  • Find Mice (IMSR)
Mice homozygous for a knock-out allele display reduced body weight, impaired motor coordination, hypoactivity, and a gender-dependent increase in anxiety levels.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 75141 NCBI Gene Model | MGI Sequence Detail 10170 C57BL/6J ±  kb
transcript NM_029182 RefSeq | MGI Sequence Detail 2810 C57BL/6  
polypeptide P63032 UniProt | EBI | MGI Sequence Detail 266 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 17
    Genomic 2
    cDNA 15

    Microarray probesets 3
Other
Accession IDs
less
MGI:2142722
References
more
  • Summaries
    All 44
    Developmental Gene Expression 2
    Gene Ontology 8
    Phenotypes 15
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:248783 Xie WR, et al., An Atoh1-S193A Phospho-Mutant Allele Causes Hearing Deficits and Motor Impairment. J Neurosci. 2017 Sep 6;37(36):8583-8594

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory