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Lrrc8d Gene Detail
Summary
  • Symbol
    Lrrc8d
  • Name
    leucine rich repeat containing 8D
  • Synonyms
    2810473G09Rik, 4930525N13Rik, Lrrc5
  • Feature Type
    protein coding gene
  • IDs
    MGI:1922368
    NCBI Gene: 231549
  • Gene Overview
    MyGene.info: LRRC8D
Location & Maps
more
  • Sequence Map
    Chr5:105699969-105832436 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      132468 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 50.68 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    LRRC8D, leucine rich repeat containing 8 family member D
  • Vertebrate Orthologs
    10
  • Human Ortholog
    LRRC8D, leucine rich repeat containing 8 family member D
    Orthology source: HGNC, HomoloGene
  • Synonyms
    LRRC5
  • Links
    NCBI Gene ID: 55144
    neXtProt AC: NX_Q7L1W4

  • Chr Location
    1p22.2; chr1:89821014-89936432 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    17 phenotype references
  • All Mutations and Alleles
    54
  • Chemically induced (other)
    1
  • Gene trapped
    48
  • Radiation induced
    1
  • Spontaneous
    1
  • Targeted
    3
  • Genomic Mutations
    3 involving Lrrc8d
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026388 VEGA Gene Model | MGI Sequence Detail 132468 C57BL/6J ±  kb
transcript OTTMUST00000065255 VEGA | MGI Sequence Detail 3923 Not Applicable  
polypeptide OTTMUSP00000032499 VEGA | MGI Sequence Detail 859 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    783 from dbSNP Build 142
Protein
Information
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  • UniProt
    5 Sequences
  • Protein Ontology
    PR:000029607 leucine-rich repeat-containing protein 8D
  • InterPro Domains
    IPR001611 Leucine-rich repeat
    IPR032675 Leucine-rich repeat domain, L domain-like
    IPR003591 Leucine-rich repeat, typical subtype
    IPR021040 LRRC8, pannexin-like TM region
Molecular
Reagents
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  • All nucleic 13
    cDNA 13

    Microarray probesets 4
Other
Accession IDs
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MGI:1920077
References
more
  • Summaries
    All 32
    Developmental Gene Expression 1
    Gene Ontology 2
    Phenotypes 17
  • Earliest
    J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-le-grand). 1999 Jul;45(5):737-50
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory