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Lrrc8d Gene Detail
Summary
  • Symbol
    Lrrc8d
  • Name
    leucine rich repeat containing 8D
  • Synonyms
    2810473G09Rik, 4930525N13Rik, Lrrc5
  • Feature Type
    protein coding gene
  • IDs
    MGI:1922368
    NCBI Gene: 231549
  • Gene Overview
    MyGene.info: LRRC8D
  • Alliance
  • Transcription Start Sites
    18 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:105699969-105815215 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 50.68 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    701 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1922368
protein coding gene Chr5:105699969-105832436 (.)
129S1/SvImJ MGP_129S1SvImJ_G0029827
protein coding gene Chr5:107604420-107748501 (+)
A/J MGP_AJ_G0029791
protein coding gene Chr5:103507703-103639020 (+)
AKR/J MGP_AKRJ_G0029736
protein coding gene Chr5:106876296-107013073 (+)
BALB/cJ MGP_BALBcJ_G0029803
protein coding gene Chr5:104653544-104787662 (+)
C3H/HeJ MGP_C3HHeJ_G0029525
protein coding gene Chr5:107293605-107432030 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030257
protein coding gene Chr5:112079904-112223203 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027492
protein coding gene Chr5:98609880-98739308 (+)
CAST/EiJ MGP_CASTEiJ_G0028939
protein coding gene Chr5:106183252-106323126 (+)
CBA/J MGP_CBAJ_G0029493
protein coding gene Chr5:115832038-115973747 (+)
DBA/2J MGP_DBA2J_G0029639
protein coding gene Chr5:103669711-103799996 (+)
FVB/NJ MGP_FVBNJ_G0029596
protein coding gene Chr5:102386617-102516286 (+)
LP/J MGP_LPJ_G0029727
protein coding gene Chr5:108210142-108346855 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029628
protein coding gene Chr5:120863322-121001700 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030291
protein coding gene Chr5:106395022-106533855 (+)
PWK/PhJ MGP_PWKPhJ_G0028652
protein coding gene Chr5:102440143-102568975 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028490
protein coding gene Chr5:103903150-104057560 (+)
WSB/EiJ MGP_WSBEiJ_G0029012
protein coding gene Chr5:106722235-106857196 (+)



Homology
more
  • Human Ortholog
    LRRC8D, leucine rich repeat containing 8 VRAC subunit D
  • Vertebrate Orthologs
    10
  • Human Ortholog
    LRRC8D, leucine rich repeat containing 8 VRAC subunit D
    Orthology source: HomoloGene, HGNC
  • Synonyms
    LRRC5
  • Links
    NCBI Gene ID: 55144
    neXtProt AC: NX_Q7L1W4
    UniProt: Q7L1W4

  • Chr Location
    1p22.2; chr1:89821014-89936432 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 10004
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: LRRC8D
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    17 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 231549 NCBI Gene Model | MGI Sequence Detail 115247 C57BL/6J ±  kb
transcript NM_001122768 RefSeq | MGI Sequence Detail 3944 C57BL/6  
polypeptide Q8BGR2 UniProt | EBI | MGI Sequence Detail 859 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 14
    cDNA 14

    Microarray probesets 4
Other
Accession IDs
less
MGI:1920077
References
more
  • Summaries
    All 42
    Developmental Gene Expression 1
    Gene Ontology 6
    Phenotypes 17
  • Earliest
    J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
  • Latest
    J:265628 Gaudet P, et al., Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief Bioinform. 2011 Sep;12(5):449-62

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory