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Mmd2
Gene Detail
Symbol

Name
ID
Mmd2
monocyte to macrophage differentiation-associated 2
MGI:1922354
Feature Type
protein coding gene
Genetic Map
Chromosome 5
81.53 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr5:142563474-142608814 bp, - strand
From NCBI annotation of GRCm38

  45341 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:18425  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 chicken; 1 zebrafish

HCOP human homology predictions: MMD2
Protein SuperFamily: hemolysin III
Gene Tree: Mmd2

Human
homologs
MMD2, monocyte to macrophage differentiation-associated 2
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 221938
neXtProt AC: NX_Q8IY49

Human Synonyms: PAQR10

Human Chr (Location): 7p22.1; chr7:4892245-4959213 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Mmd2 interacts with 232 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (12 annotations)
Process cytolysis, positive regulation of neuron differentiation, ...
Component Golgi apparatus, integral component of membrane, ...
Function protein kinase activity
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (458)    Tissues (58)    Images (52)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 446
RT-PCR 12
cDNA source data(31)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: ZFIN mmd2a    NEW 
Molecular
reagents
All nucleic(33) cDNA(31) Primer pair(2)
Microarray probesets(6)
Other database
links
Ensembl Gene Model ENSMUSG00000039533 (Evidence)
Entrez Gene 75104 (Evidence)
UniGene 48712
DFCI TC1576734, TC1665485
DoTS DT.485023, DT.101206837
NIA Mouse Gene Index U026903
Consensus CDS Project CCDS39363.1
International Mouse Phenotyping Consortium Status Mmd2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 75104 NCBI Gene Model | MGI Sequence Detail 45341 C57BL/6J ±  kb
transcript NM_175217 RefSeq | MGI Sequence Detail 2159 C57BL/6 
polypeptide Q8R189 UniProt | EBI | MGI Sequence Detail 247 Not Applicable 

For the selected sequences
All sequences(29) RefSeq(6) UniProt(2)
Polymorphisms
SNPs within 2kb(243 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004254 Hly-III-related
InterPro IPR005744 HylII
Protein Ontology PR:000010466 monocyte to macrophage differentiation factor 2
Graphical View of Protein Domain Structure
References
(Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:194893 Yu K, et al., Floor plate-derived sonic hedgehog regulates glial and ependymal cell fates in the developing spinal cord. Development. 2013 Apr;140(7):1594-604
All references(33)
Other
accession IDs
MGI:2141345

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/30/2015
MGI 5.22
The Jackson Laboratory