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Usp50 Gene Detail
Summary
  • Symbol
    Usp50
  • Name
    ubiquitin specific peptidase 50
  • Synonyms
    1700086G18Rik, 4930511O11Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1922333
    NCBI Gene: 75083
Location & Maps
more
  • Sequence Map
    Chr2:126709096-126783458 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      74363 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 61.76 cM, cytoband F2
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    USP50, ubiquitin specific peptidase 50
  • Vertebrate Orthologs
    7
  • Human Ortholog
    USP50, ubiquitin specific peptidase 50
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 373509
    neXtProt AC: NX_Q70EL3

  • Chr Location
    15q21.1; chr15:50493681-50547439 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    14
  • Chemically induced (other)
    1
  • Gene trapped
    11
  • Radiation induced
    1
  • Targeted
    1
  • Genomic Mutations
    2 involving Usp50
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000015955 VEGA Gene Model | MGI Sequence Detail 74363 C57BL/6J ±  kb
transcript OTTMUST00000037921 VEGA | MGI Sequence Detail 1361 Not Applicable  
polypeptide OTTMUSP00000017022 VEGA | MGI Sequence Detail 390 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    640 from dbSNP Build 142
Protein
Information
less
  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000017190 inactive ubiquitin carboxyl-terminal hydrolase 50
  • EC
  • InterPro Domains
    IPR000268 DNA-directed RNA polymerase, subunit N/Rpb10
    IPR009057 Homeodomain-like
    IPR001394 Peptidase C19, ubiquitin carboxyl-terminal hydrolase
    IPR020789 RNA polymerases, subunit N, zinc binding site
    IPR023580 RNA polymerase subunit RPB10
    IPR018200 Ubiquitin specific protease, conserved site
    IPR028889 Ubiquitin specific protease domain
Molecular
Reagents
less
  • All nucleic 18
    cDNA 18

    Microarray probesets 3
Other
Accession IDs
less
MGI:1923866
References
more
  • Summaries
    All 26
    Gene Ontology 3
    Phenotypes 8
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
09/27/2016
MGI 6.05
The Jackson Laboratory