Stk38l MGI Mouse Gene Detail - MGI:1922250 - serine/threonine kinase 38 like

Symbol

Stk38l
Name

serine/threonine kinase 38 like
Synonyms

4930473A22Rik, Ndr2

Feature Type

protein coding gene
IDs

MGI:1922250
NCBI Gene: 232533
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr6:146626493-146680310 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 6, 77.70 cM
Mapping Data

1 experiment

SNPs within 2kb

509 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1922250	protein coding gene	Chr6:146626428-146680312 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0031490	protein coding gene	Chr6:151746159-151802885 (+)
A/J	MGP_AJ_G0031465	protein coding gene	Chr6:145735159-145792036 (+)
AKR/J	MGP_AKRJ_G0031393	protein coding gene	Chr6:150057291-150121012 (+)
BALB/cJ	MGP_BALBcJ_G0031473	protein coding gene	Chr6:145473843-145545495 (+)
C3H/HeJ	MGP_C3HHeJ_G0031194	protein coding gene	Chr6:150122265-150180794 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0031934	protein coding gene	Chr6:155802781-155859338 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0029058	protein coding gene	Chr6:144451550-144533245 (+)
CAST/EiJ	MGP_CASTEiJ_G0030563	protein coding gene	Chr6:149757855-149819467 (+)
CBA/J	MGP_CBAJ_G0031154	protein coding gene	Chr6:161742652-161798717 (+)
DBA/2J	MGP_DBA2J_G0031310	protein coding gene	Chr6:144516879-144572191 (+)
FVB/NJ	MGP_FVBNJ_G0031262	protein coding gene	Chr6:143250682-143311915 (+)
LP/J	MGP_LPJ_G0031396	protein coding gene	Chr6:151834305-151892495 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0031302	protein coding gene	Chr6:165473037-165533185 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0031967	protein coding gene	Chr6:149889173-149949251 (+)
PWK/PhJ	MGP_PWKPhJ_G0030289	protein coding gene	Chr6:143034813-143090394 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0030113	protein coding gene	Chr6:148043589-148104842 (+)
WSB/EiJ	MGP_WSBEiJ_G0030656	protein coding gene	Chr6:150512075-150568209 (+)

Human Ortholog

STK38L, serine/threonine kinase 38 like

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

STK38L, serine/threonine kinase 38 like
Synonyms

NDR2
Links

HGNC:17848

NCBI Gene ID: 23012

neXtProt AC: NX_Q9Y2H1

UniProt: Q9Y2H1
Chr Location

12p11.23; chr12:27243968-27325959 (+) GRCh38

MGI Vertebrate Homology

Stk38l stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: STK38L
Gene Tree

Stk38l

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Phenotype Summary

6 phenotypes from 2 alleles in 2 genetic backgrounds
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

27
Endonuclease-mediated

2
Gene trapped

20
Targeted

5
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

37 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous gene-trapped mice exhibit premature dendritic branching of CA3 pyramidal neurons. Mice homozygous for a knock-out allele exhibit mislocalization of opsin, increased apoptosis and proliferation of interneurons in the inner nuclear layer and disrupted localization of amacrine cells.

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All GO Annotations

26
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

42

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase stk38l

ZFIN stk38l

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All Sequences

67
RefSeq

23
UniProt

2
CCDS

CCDS39712.1

Ensembl

ENSMUSG00000001630 (Evidence)
NCBI Gene

232533

			Length	Strain/Species	Flank
genomic	ENSMUSG00000001630	Ensembl Gene Model \| MGI Sequence Detail	53818	C57BL/6J	± kb
transcript	ENSMUST00000111644	Ensembl \| MGI Sequence Detail	2274	Not Applicable
polypeptide	ENSMUSP00000107271	Ensembl \| MGI Sequence Detail	471	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000015755 serine/threonine-protein kinase 38-like

(term hierarchy)
EC

2.7.11.1
InterPro Domains

IPR000961 AGC-kinase, C-terminal

IPR017441 Protein kinase, ATP binding site

IPR017892 Protein kinase, C-terminal

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

IPR008271 Serine/threonine-protein kinase, active site

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All nucleic 42

cDNA 42

Microarray probesets 6

Summaries

All 41

Gene Ontology 10

Phenotypes 13
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:334284 Wang S, et al., LPA maintains innate antiviral immunity in a pro-active state via STK38L-mediated IRF3 Ser303 phosphorylation. Cell Rep. 2022 Nov 22;41(8):111661

TSS for Stk38l:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr59588	Chr6:146626455-146626496 (+)	-17 bp
Tssr59589	Chr6:146626503-146626525 (+)	21 bp
Tssr59590	Chr6:146653838-146653857 (+)	27,355 bp
Tssr59591	Chr6:146658529-146658544 (+)	32,044 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/09/2024 MGI 6.23