Usp47 MGI Mouse Gene Detail - MGI:1922246 - ubiquitin specific peptidase 47

Symbol

Usp47
Name

ubiquitin specific peptidase 47
Synonyms

4930502N04Rik, A630020C16Rik

Feature Type

protein coding gene
IDs

MGI:1922246
NCBI Gene: 74996
Gene Overview

MyGene.info: USP47
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr7:112023476-112111386 bp, + strand
From NCBI annotation of GRCm38

View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 58.74 cM, cytoband F2
Mapping Data

3 experiments

SNPs within 2kb

628 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1922246	protein coding gene	Chr7:112023476-112111661 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0032866	protein coding gene	Chr7:115564351-115666058 (+)
A/J	MGP_AJ_G0032849	protein coding gene	Chr7:112700518-112789915 (+)
AKR/J	MGP_AKRJ_G0032781	protein coding gene	Chr7:115536357-115624446 (+)
BALB/cJ	MGP_BALBcJ_G0032854	protein coding gene	Chr7:112380667-112468414 (+)
C3H/HeJ	MGP_C3HHeJ_G0032564	protein coding gene	Chr7:115518024-115617962 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0033360	protein coding gene	Chr7:120305310-120403536 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0030332	protein coding gene	Chr7:114300825-114390322 (+)
CAST/EiJ	MGP_CASTEiJ_G0031892	protein coding gene	Chr7:107134767-107226517 (+)
CBA/J	MGP_CBAJ_G0032537	protein coding gene	Chr7:124258783-124354960 (+)
DBA/2J	MGP_DBA2J_G0032689	protein coding gene	Chr7:110785891-110875453 (+)
FVB/NJ	MGP_FVBNJ_G0032642	protein coding gene	Chr7:110632072-110722460 (+)
LP/J	MGP_LPJ_G0032783	protein coding gene	Chr7:117082077-117174020 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0032674	protein coding gene	Chr7:125863360-125969638 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0033380	protein coding gene	Chr7:114537217-114630383 (+)
PWK/PhJ	MGP_PWKPhJ_G0031599	protein coding gene	Chr7:103623558-103712348 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0031447	protein coding gene	Chr7:101286749-101381998 (+)
WSB/EiJ	MGP_WSBEiJ_G0032005	protein coding gene	Chr7:115398280-115489720 (+)

Human Ortholog

USP47, ubiquitin specific peptidase 47

Vertebrate Orthologs

9

Human Ortholog

USP47, ubiquitin specific peptidase 47
Orthology source: HomoloGene, HGNC
Synonyms

TRFP
Links

HGNC:20076

NCBI Gene ID: 55031

neXtProt AC: NX_Q96K76

UniProt: Q96K76
Chr Location

11p15.3; chr11:11841423-11959325 (+) GRCh38.p7

HomoloGene

Vertebrate Homology Class 9929
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: USP47
Gene Tree

Usp47

less

Phenotype Summary

8 phenotypes from 2 alleles in 2 genetic backgrounds
21 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

18
Endonuclease-mediated

1
Gene trapped

11
Radiation induced

1
Targeted

5
Genomic Mutations

1 involving Usp47
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

49 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mouse embryonic fibroblasts from mice homozygous for a gene trap allele exhibit increased sensitivity to UV irradiation.

less

All GO Annotations

35
GO References

5

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

631
cDNA Data

15

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase usp47

less

Usp47 interacts with 266 markers (Mir7-1, Mir9-1, Mir9-2, ...) View All

less

All Sequences

65
RefSeq

8
UniProt

4
CCDS

CCDS40089.1, CCDS85384.1, CCDS90312.1

Ensembl

ENSMUSG00000059263 (Evidence)
NCBI Gene

74996

			Length	Strain/Species	Flank
genomic	74996	NCBI Gene Model \| MGI Sequence Detail	87911	C57BL/6J	± kb
transcript	NM_001357952	RefSeq \| MGI Sequence Detail	5600	C57BL/6
polypeptide	Q8BY87	UniProt \| EBI \| MGI Sequence Detail	1376	Not Applicable

less

UniProt

4 Sequences
Protein Ontology

PR:000017186 ubiquitin carboxyl-terminal hydrolase 47

(term hierarchy)
EC

3.4.19.12
InterPro Domains

IPR038765 Papain-like cysteine peptidase superfamily

IPR001394 Peptidase C19, ubiquitin carboxyl-terminal hydrolase

IPR029071 Ubiquitin-like domain superfamily

IPR018200 Ubiquitin specific protease, conserved site

IPR028889 Ubiquitin specific protease domain

less

All nucleic 16

cDNA 16

Microarray probesets 4

less

MGI:2444648

Summaries

All 47

Gene Ontology 5

Phenotypes 21
Earliest

J:61682 Hagiwara N, et al., Sox6 is a candidate gene for p100H myopathy, heart block, and sudden neonatal death. Proc Natl Acad Sci U S A. 2000 Apr 11;97(8):4180-5
Latest

J:236599 Dickinson ME, et al., High-throughput discovery of novel developmental phenotypes. Nature. 2016 Sep 14;537(7621):508-514

TSS for Usp47:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr68546	Chr7:112023251-112023317 (+)	-192 bp
Tssr68547	Chr7:112023433-112023444 (+)	-37 bp
Tssr68548	Chr7:112023447-112023462 (+)	-21 bp
Tssr68549	Chr7:112023469-112023566 (+)	42 bp
Tssr68550	Chr7:112023577-112023590 (+)	108 bp
Tssr68551	Chr7:112074651-112074677 (+)	51,188 bp
Tssr68555	Chr7:112093077-112093127 (+)	69,626 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 01/19/2021 MGI 6.16