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Armc4 Gene Detail
Summary
  • Symbol
    Armc4
  • Name
    armadillo repeat containing 4
  • Synonyms
    4930463I21Rik, b2b227.1Clo, b2b643Clo
  • Feature Type
    protein coding gene
  • IDs
    MGI:1922184
    NCBI Gene: 74934
  • Alliance
Location &
Maps
more
  • Sequence Map
    Chr18:7088209-7297936 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 18, 4.53 cM, cytoband A1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    796 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1922184
protein coding gene Chr18:7088209-7298304 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024134
protein coding gene Chr18:3976884-4170724 (-)
A/J MGP_AJ_G0024096
protein coding gene Chr18:4002393-4220514 (-)
AKR/J MGP_AKRJ_G0024064
protein coding gene Chr18:4071943-4286060 (-)
BALB/cJ MGP_BALBcJ_G0024096
protein coding gene Chr18:3946310-4147342 (-)
C3H/HeJ MGP_C3HHeJ_G0023862
protein coding gene Chr18:3972868-4182468 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024541
protein coding gene Chr18:4240997-4455967 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021980
protein coding gene Chr18:3713344-3907575 (-)
CAST/EiJ MGP_CASTEiJ_G0023340
protein coding gene Chr18:3979101-4192328 (-)
CBA/J MGP_CBAJ_G0023835
protein coding gene Chr18:4150152-4370697 (-)
DBA/2J MGP_DBA2J_G0023963
protein coding gene Chr18:3841909-4047318 (-)
FVB/NJ MGP_FVBNJ_G0023929
protein coding gene Chr18:3834588-4034792 (-)
LP/J MGP_LPJ_G0024047
protein coding gene Chr18:4005244-4217268 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023957
protein coding gene Chr18:4282519-4499085 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024586
protein coding gene Chr18:3946299-4155456 (-)
PWK/PhJ MGP_PWKPhJ_G0023085
protein coding gene Chr18:3894725-4100721 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022896
protein coding gene Chr18:4204571-4422210 (-)
WSB/EiJ MGP_WSBEiJ_G0023406
protein coding gene Chr18:3917665-4127619 (-)



Homology
more
  • Human Ortholog
    ARMC4, armadillo repeat containing 4
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ARMC4, armadillo repeat containing 4
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CILD23
  • Links
    NCBI Gene ID: 55130
    neXtProt AC: NX_Q5T2S8
    UniProt: Q5T2S8

  • Chr Location
    10p12.1; chr10:27796355-27999050 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    3 with Armc4 mouse models; 1 with human ARMC4 associations

Human Disease Mouse Models
      
IDs
View 2 models
      
IDs
View 1 model
IDs
View 2 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    24 phenotypes from 2 alleles in 2 genetic backgrounds
    36 images
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for ENU-induced mutations exhibit situs inversus totalis or heterotaxia with congenital heart disease including double outlet right ventricle and ventricular septal defects. Dyskinetic, slow, or immotile airway cilia are also observed.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000061802 Ensembl Gene Model | MGI Sequence Detail 209728 C57BL/6J ±  kb
    transcript ENSMUST00000234788 Ensembl | MGI Sequence Detail 3508 Not Applicable  
    polypeptide ENSMUSP00000157197 Ensembl | MGI Sequence Detail 1037 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 4
      cDNA 4

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:5311339, MGI:5437094
    References
    more
    • Summaries
      All 25
      Developmental Gene Expression 1
      Diseases 2
      Gene Ontology 5
      Phenotypes 6
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:222159 Li Y, et al., Global genetic analysis in mice unveils central role for cilia in congenital heart disease. Nature. 2015 May 28;521(7553):520-4

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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    Funding Information
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    last database update
    08/13/2019
    MGI 6.14
    The Jackson Laboratory