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Armc4 Gene Detail
Summary
  • Symbol
    Armc4
  • Name
    armadillo repeat containing 4
  • Synonyms
    4930463I21Rik, b2b227.1Clo, b2b643Clo
  • Feature Type
    protein coding gene
  • IDs
    MGI:1922184
    NCBI Gene: 74934
Location & Maps
more
  • Sequence Map
    Chr18:7088233-7297901 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      209669 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 18, 4.53 cM, cytoband A1
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    ARMC4, armadillo repeat containing 4
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ARMC4, armadillo repeat containing 4
    Orthology source: HomoloGene
  • Synonyms
    CILD23
  • Links
    NCBI Gene ID: 55130
    neXtProt AC: NX_Q5T2S8

  • Chr Location
    10p12.1; chr10:27812164-27999067 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Armc4 mouse models; 1 with human ARMC4 associations

Human Disease Mouse Models
       Ciliary Dyskinesia, Primary, 23; CILD23   OMIM: 615451 View 2 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    24 phenotypes from 2 alleles in 2 genetic backgrounds
    36 images
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    6
  • Chemically induced (ENU)
    2
  • Gene trapped
    2
  • Targeted
    2
  • Incidental Mutations
Mice homozygous for ENU-induced mutations exhibit situs inversus totalis or heterotaxia with congenital heart disease including double outlet right ventricle and ventricular septal defects. Dyskinetic, slow, or immotile airway cilia are also observed.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000061802 Ensembl Gene Model | MGI Sequence Detail 209669 C57BL/6J ±  kb
transcript ENSMUST00000081275 Ensembl | MGI Sequence Detail 3477 Not Applicable  
polypeptide ENSMUSP00000080028 Ensembl | MGI Sequence Detail 1037 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    796 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 3
    cDNA 3

    Microarray probesets 3
Other
Accession IDs
less
MGI:5311339, MGI:5437094
References
more
  • Summaries
    All 24
    Developmental Gene Expression 1
    Diseases 2
    Gene Ontology 6
    Phenotypes 5
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:222159 Li Y, et al., Global genetic analysis in mice unveils central role for cilia in congenital heart disease. Nature. 2015 May 28;521(7553):520-4

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory