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Timmdc1 Gene Detail
Summary
  • Symbol
    Timmdc1
  • Name
    translocase of inner mitochondrial membrane domain containing 1
  • Synonyms
    2810021C21Rik, 4930455C21Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1922139
    NCBI Gene: 76916
  • Gene Overview
    MyGene.info: TIMMDC1
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:38498347-38522663 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 26.86 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    194 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1922139
protein coding gene Chr16:38497843-38522704 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022817
protein coding gene Chr16:37029122-37054742 (-)
A/J MGP_AJ_G0022782
protein coding gene Chr16:35190384-35214495 (-)
AKR/J MGP_AKRJ_G0022754
protein coding gene Chr16:36531028-36555107 (-)
BALB/cJ MGP_BALBcJ_G0022783
protein coding gene Chr16:35314877-35339030 (-)
C3H/HeJ MGP_C3HHeJ_G0022547
protein coding gene Chr16:36635749-36662121 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023230
protein coding gene Chr16:37873631-37899461 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020745
protein coding gene Chr16:35570570-35596109 (-)
CAST/EiJ MGP_CASTEiJ_G0022073
protein coding gene Chr16:36790563-36814891 (-)
CBA/J MGP_CBAJ_G0022518
protein coding gene Chr16:39530640-39554569 (-)
DBA/2J MGP_DBA2J_G0022650
protein coding gene Chr16:35075753-35100884 (-)
FVB/NJ MGP_FVBNJ_G0022625
protein coding gene Chr16:35106138-35131071 (-)
LP/J MGP_LPJ_G0022718
protein coding gene Chr16:36709550-36734132 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022644
protein coding gene Chr16:38646193-38674069 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023245
protein coding gene Chr16:36493423-36519152 (-)
PWK/PhJ MGP_PWKPhJ_G0021813
protein coding gene Chr16:35491436-35518725 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021644
protein coding gene Chr16:36385482-36411366 (-)
WSB/EiJ MGP_WSBEiJ_G0022117
protein coding gene Chr16:36558146-36587884 (-)



Homology
more
  • Human Ortholog
    TIMMDC1, translocase of inner mitochondrial membrane domain containing 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    TIMMDC1, translocase of inner mitochondrial membrane domain containing 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    C3orf1
  • Links
    NCBI Gene ID: 51300
    neXtProt AC: NX_Q9NPL8
    UniProt: Q9NPL8

  • Chr Location
    3q13.33; chr3:119498521-119524281 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human TIMMDC1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 2 alleles in 2 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trap allele exhibit lethality. Heterozygous mice show an increased mean percentage of CD4 cells in the peripheral blood compared with controls, but no other notable heterozygous phenotype was detected.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000002846 Ensembl Gene Model | MGI Sequence Detail 24317 C57BL/6J ±  kb
transcript ENSMUST00000002925 Ensembl | MGI Sequence Detail 1573 Not Applicable  
polypeptide ENSMUSP00000002925 Ensembl | MGI Sequence Detail 285 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 18
    cDNA 18

    Microarray probesets 3
Other
Accession IDs
less
MGI:1924166, MGI:2146599
References
more
  • Summaries
    All 36
    Gene Ontology 3
    Phenotypes 12
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:261316 Perez-Garcia V, et al., Placentation defects are highly prevalent in embryonic lethal mouse mutants. Nature. 2018 Mar 22;555(7697):463-468

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory