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Senp6 Gene Detail
Summary
  • Symbol
    Senp6
  • Name
    SUMO/sentrin specific peptidase 6
  • Synonyms
    2810017C20Rik, E130319N12Rik, mKIAA0797
  • Feature Type
    protein coding gene
  • IDs
    MGI:1922075
    NCBI Gene: 215351
  • Gene Overview
    MyGene.info: SENP6
Location & Maps
more
  • Sequence Map
    Chr9:80066903-80144953 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      78051 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 43.88 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    SENP6, SUMO1/sentrin specific peptidase 6
  • Vertebrate Orthologs
    8
  • Human Ortholog
    SENP6, SUMO1/sentrin specific peptidase 6
    Orthology source: HomoloGene, HGNC
  • Synonyms
    SSP1, SUSP1
  • Links
    NCBI Gene ID: 26054
    neXtProt AC: NX_Q9GZR1

  • Chr Location
    6q14.1; chr6:75601509-75718285 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    49
  • Chemically induced (other)
    1
  • Gene trapped
    44
  • Radiation induced
    1
  • Targeted
    3
  • Genomic Mutations
    2 involving Senp6
  • Incidental Mutations
Mice homozygous for a gene trap insertion exhibit prenatal lethality.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000042004 VEGA Gene Model | MGI Sequence Detail 78051 C57BL/6J ±  kb
transcript OTTMUST00000110048 VEGA | MGI Sequence Detail 3495 Not Applicable  
polypeptide OTTMUSP00000061325 VEGA | MGI Sequence Detail 1139 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    381 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 163
    cDNA 163

    Microarray probesets 6
Other
Accession IDs
less
MGI:2442129
References
more
  • Summaries
    All 33
    Developmental Gene Expression 1
    Gene Ontology 4
    Phenotypes 15
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:213375 Liu X, et al., Negative regulation of TLR inflammatory signaling by the SUMO-deconjugating enzyme SENP6. PLoS Pathog. 2013;9(6):e1003480

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory