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Senp6 Gene Detail
Summary
  • Symbol
    Senp6
  • Name
    SUMO/sentrin specific peptidase 6
  • Synonyms
    2810017C20Rik, E130319N12Rik, mKIAA0797
  • Feature Type
    protein coding gene
  • IDs
    MGI:1922075
    NCBI Gene: 215351
  • Gene Overview
    MyGene.info: SENP6
  • Alliance
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:80066903-80144782 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 43.88 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    380 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1922075
protein coding gene Chr9:80066903-80144953 (.)
129S1/SvImJ MGP_129S1SvImJ_G0035078
protein coding gene Chr9:80631579-80712734 (+)
A/J MGP_AJ_G0035059
protein coding gene Chr9:77856410-77940005 (+)
AKR/J MGP_AKRJ_G0034987
protein coding gene Chr9:79678117-79758794 (+)
BALB/cJ MGP_BALBcJ_G0035047
protein coding gene Chr9:77487638-77567419 (+)
C3H/HeJ MGP_C3HHeJ_G0034759
protein coding gene Chr9:80200958-80283661 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035570
protein coding gene Chr9:82811083-82895408 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032477
protein coding gene Chr9:76999281-77082712 (+)
CAST/EiJ MGP_CASTEiJ_G0034077
protein coding gene Chr9:80547824-80631339 (+)
CBA/J MGP_CBAJ_G0034732
protein coding gene Chr9:85767391-85855380 (+)
DBA/2J MGP_DBA2J_G0034890
protein coding gene Chr9:77468226-77551296 (+)
FVB/NJ MGP_FVBNJ_G0034833
protein coding gene Chr9:76683091-76763555 (+)
LP/J MGP_LPJ_G0034971
protein coding gene Chr9:80869291-80952986 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034875
protein coding gene Chr9:86989073-87076929 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035591
protein coding gene Chr9:79907657-79994474 (+)
PWK/PhJ MGP_PWKPhJ_G0033781
protein coding gene Chr9:77674409-77753343 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033617
protein coding gene Chr9:80046456-80129150 (+)
WSB/EiJ MGP_WSBEiJ_G0034194
protein coding gene Chr9:79836198-79922823 (+)



Homology
more
  • Human Ortholog
    SENP6, SUMO specific peptidase 6
  • Vertebrate Orthologs
    8
  • Human Ortholog
    SENP6, SUMO specific peptidase 6
    Orthology source: HGNC, HomoloGene
  • Synonyms
    SSP1, SUSP1
  • Links
    NCBI Gene ID: 26054
    neXtProt AC: NX_Q9GZR1
    UniProt: Q9GZR1

  • Chr Location
    6q14.1; chr6:75601509-75718285 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trap insertion exhibit prenatal lethality.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 215351 NCBI Gene Model | MGI Sequence Detail 77880 C57BL/6J ±  kb
transcript NM_001311110 RefSeq | MGI Sequence Detail 4976 C57BL/6  
polypeptide Q6P7W0 UniProt | EBI | MGI Sequence Detail 1132 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    8 Sequences
  • EC
  • InterPro Domains
    IPR038765 Papain-like cysteine peptidase superfamily
    IPR003653 Ulp1 protease family, C-terminal catalytic domain
Molecular
Reagents
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  • All nucleic 164
    cDNA 164

    Microarray probesets 6
Other
Accession IDs
less
MGI:2442129
References
more
  • Summaries
    All 41
    Developmental Gene Expression 1
    Gene Ontology 5
    Phenotypes 16
  • Earliest
    J:12013 Russell LB, Definition of functional units in a small chromosomal segment of the mouse and its use in interpreting the nature of radiation-induced mutations. Mutat Res. 1971 Jan;11(1):107-23
  • Latest
    J:213375 Liu X, et al., Negative regulation of TLR inflammatory signaling by the SUMO-deconjugating enzyme SENP6. PLoS Pathog. 2013;9(6):e1003480

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/04/2018
MGI 6.13
The Jackson Laboratory