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E2f8 Gene Detail
Summary
  • Symbol
    E2f8
  • Name
    E2F transcription factor 8
  • Synonyms
    4432406C08Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1922038
    NCBI Gene: 108961
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:48516177-48531344 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 31.11 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    513 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1922038
 protein coding gene Chr7:48516177-48531821 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032296
 protein coding gene Chr7:49473810-49488975 (-)
A/J MGP_AJ_G0032275
 protein coding gene Chr7:48779071-48794234 (-)
AKR/J MGP_AKRJ_G0032211
 protein coding gene Chr7:49924202-49939369 (-)
BALB/cJ MGP_BALBcJ_G0032287
 protein coding gene Chr7:48425654-48440821 (-)
C3H/HeJ MGP_C3HHeJ_G0032000
 protein coding gene Chr7:50296590-50311757 (-)
C57BL/6NJ MGP_C57BL6NJ_G0032780
 protein coding gene Chr7:51778869-51794036 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029786
 protein coding gene Chr7:51953023-51968198 (-)
CAST/EiJ MGP_CASTEiJ_G0031328
 protein coding gene Chr7:41678152-41693358 (-)
CBA/J MGP_CBAJ_G0031965
 protein coding gene Chr7:53514473-53529640 (-)
DBA/2J MGP_DBA2J_G0032122
 protein coding gene Chr7:47988175-48003342 (-)
FVB/NJ MGP_FVBNJ_G0032076
 protein coding gene Chr7:47916592-47932026 (-)
LP/J MGP_LPJ_G0032203
 protein coding gene Chr7:50436156-50452610 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032113
 protein coding gene Chr7:52637759-52652928 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0032797
 protein coding gene Chr7:48902181-48917348 (-)
PWK/PhJ MGP_PWKPhJ_G0031048
 protein coding gene Chr7:41323602-41338969 (-)
SPRET/EiJ MGP_SPRETEiJ_G0030889
 protein coding gene Chr7:37073131-37088305 (-)
WSB/EiJ MGP_WSBEiJ_G0031446
 protein coding gene Chr7:49557176-49573399 (-)



Homology
more
  • Human Ortholog
    E2F8, E2F transcription factor 8
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    E2F8, E2F transcription factor 8
  • Synonyms
    E2F-8
  • Links
    NCBI Gene ID: 79733
    UniProt: A0AVK6

  • Chr Location
    11p15.1; chr11:19224063-19241655 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    24 phenotypes from multigenic genotypes
    20 phenotype references
Mice homozygous for a knock-out allele develop normally through puberty and live to old age.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    58
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    736
  • Tissues
    30
  • cDNA Data
    19
  • Literature Summary
    10
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000046179 Ensembl Gene Model | MGI Sequence Detail 15168 C57BL/6J ±  kb
transcript ENSMUST00000058745 Ensembl | MGI Sequence Detail 3691 Not Applicable  
polypeptide ENSMUSP00000056778 Ensembl | MGI Sequence Detail 860 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 19
    cDNA 19

    Microarray probesets 6
Other
Accession IDs
less
MGI:2141825
References
more
  • Summaries
    All 63
    Developmental Gene Expression 10
    Gene Ontology 12
    Phenotypes 20
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:351856 Park SA, et al., Opposing functions of circadian protein DBP and atypical E2F family E2F8 in anti-tumor Th9 cell differentiation. Nat Commun. 2022 Oct 14;13(1):6069
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory