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E2f8 Gene Detail
Summary
  • Symbol
    E2f8
  • Name
    E2F transcription factor 8
  • Synonyms
    4432406C08Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1922038
    NCBI Gene: 108961
Location & Maps
more
  • Sequence Map
    Chr7:48866429-48881596 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      15168 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 31.11 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    E2F8, E2F transcription factor 8
  • Vertebrate Orthologs
    10
  • Human Ortholog
    E2F8, E2F transcription factor 8
    Orthology source: HomoloGene, HGNC
  • Synonyms
    E2F-8
  • Links
    NCBI Gene ID: 79733
    neXtProt AC: NX_A0AVK6

  • Chr Location
    11p15.1; chr11:19224063-19241655 (-)  GRCh38.p2
  • HomoloGene
    Vertebrate Homology Class 11654
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: E2F8
  • Gene Tree
    E2f8
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    24 phenotypes from multigenic genotypes
    12 phenotype references
Mice homozygous for a knock-out allele develop normally through puberty and live to old age.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    27
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    29
  • Tissues
    29
  • cDNA Data
    18
  • Literature Summary
    7
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000029718 VEGA Gene Model | MGI Sequence Detail 15168 C57BL/6J ±  kb
transcript OTTMUST00000073729 VEGA | MGI Sequence Detail 3691 Not Applicable  
polypeptide OTTMUSP00000038213 VEGA | MGI Sequence Detail 860 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    165 from dbSNP Build 142
Protein
Information
less
  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000006859 transcription factor E2F8
  • PDB
    1WZH
  • InterPro Domains
    IPR003316 E2F/DP family, winged-helix DNA-binding domain
    IPR015633 E2F Family
    IPR011991 Winged helix-turn-helix DNA-binding domain
Molecular
Reagents
less
  • All nucleic 18
    cDNA 18

    Microarray probesets 6
Other
Accession IDs
less
MGI:2141825
References
more
  • Summaries
    All 46
    Developmental Gene Expression 7
    Gene Ontology 8
    Phenotypes 12
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:233777 Ray JP, et al., The Interleukin-2-mTORc1 Kinase Axis Defines the Signaling, Differentiation, and Metabolism of T Helper 1 and Follicular B Helper T Cells. Immunity. 2015 Oct 20;43(4):690-702
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/27/2016
MGI 6.05 		The Jackson Laboratory