Atp13a2
Gene Detail

Symbol Name ID

Atp13a2 ATPase type 13A2 MGI:1922022

Synonyms

1110012E06Rik

Feature Type

protein coding gene

Genetic Map

Chromosome 4

73.29 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr4:140986873-141007330 bp, + strand From VEGA annotation of GRCm38   20458 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:56940  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Gene Tree: Atp13a2

Human homologs

Human Homolog		ATP13A2, ATPase type 13A2
NCBI Gene ID		23400
neXtProt AC		NX_Q9NQ11
Human Synonyms		CLN12, HSA9947, KRPPD, PARK9
Human Chr (Location)		1p36; chr1:17312453-17338423 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human ATP13A2

Alleles and phenotypes

All alleles(5) : Targeted(4) Gene trapped(1)
 

Mice homozygous for a knock-out allele exhibit neuronal ceroid lipofuscinosis, synuclein accumulation and age-dependent sensorimotor deficits.

 

Gene Ontology (GO) classifications

All GO classifications: (13 annotations)

Process	cation transport
Component	integral to membrane, lysosome, ...
Function	ATPase activity, ATP binding, ...

External Resources: FuncBase

Expression

Literature Summary: (2 records)
Data Summary: Results (54)    Tissues (11)    Images (18)
Theiler Stages: 23

Assay Type	Results
RNA in situ	54

cDNA source data(131)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(132) cDNA(131) Primer pair(1)
Microarray probesets(8)

Other database links

VEGA Gene Model	OTTMUSG00000010089 (Evidence)
Ensembl Gene Model	ENSMUSG00000036622 (Evidence)
Entrez Gene	74772 (Evidence)
UniGene	205625
DFCI	TC1572463, TC1594531, TC1642465, TC1682354
DoTS	DT.101394743, DT.101394758, DT.101723823, DT.97358759, DT.97369392
NIA Mouse Gene Index	U020750
EC	3.6.3.-
Consensus CDS Project	CCDS18859.1, CCDS51345.1
International Mouse Knockout Project Status	Atp13a2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000010089	VEGA Gene Model | MGI Sequence Detail	20458	C57BL/6J
transcript	OTTMUST00000023462	VEGA | MGI Sequence Detail	3956	Not Applicable
polypeptide	OTTMUSP00000010718	VEGA | MGI Sequence Detail	1169	Not Applicable

All sequences(86) RefSeq(4) UniProt(4)

Polymorphisms

SNPs(116 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001757	Cation-transporting P-type ATPase
InterPro	IPR004014	Cation-transporting P-type ATPase, N-terminal
InterPro	IPR006544	Cation-transporting P-type ATPase, subfamily V
InterPro	IPR023214	HAD-like domain
InterPro	IPR008250	P-type ATPase, A domain
InterPro	IPR023299	P-type ATPase, cytoplasmic domain N
InterPro	IPR018303	P-type ATPase, phosphorylation site
Protein Ontology	PR:000031171	probable cation-transporting ATPase 13A2

References

(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:194306 Schultheis PJ, et al., Atp13a2-deficient mice exhibit neuronal ceroid lipofuscinosis, limited alpha-synuclein accumulation and age-dependent sensorimotor deficits. Hum Mol Genet. 2013 Feb 26;
All references(35)

Other accession IDs

MGI:2140166