Rab3il1 MGI Mouse Gene Detail - MGI:1922010 - RAB3A interacting protein (rabin3)-like 1

Symbol

Rab3il1
Name

RAB3A interacting protein (rabin3)-like 1
Synonyms

1200014K04Rik, Rab3ail1

Feature Type

protein coding gene
IDs

MGI:1922010
NCBI Gene: 74760
Alliance

gene page
Transcription Start Sites

10 TSS

Sequence Map

Chr19:9979033-10015744 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 19, 6.26 cM
Mapping Data

2 experiments

SNPs within 2kb

203 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1922010	protein coding gene	Chr19:9979033-10015744 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0024835	protein coding gene	Chr19:7321843-7344625 (+)
A/J	MGP_AJ_G0024803	protein coding gene	Chr19:6806364-6844348 (+)
AKR/J	MGP_AKRJ_G0024778	protein coding gene	Chr19:7094350-7117706 (+)
BALB/cJ	MGP_BALBcJ_G0024803	protein coding gene	Chr19:6851404-6889087 (+)
C3H/HeJ	MGP_C3HHeJ_G0024569	protein coding gene	Chr19:6966154-7004398 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0025251	protein coding gene	Chr19:7646640-7677043 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022678	protein coding gene	Chr19:7225230-7261872 (+)
CAST/EiJ	MGP_CASTEiJ_G0024042	protein coding gene	Chr19:6631517-6656380 (+)
CBA/J	MGP_CBAJ_G0024543	protein coding gene	Chr19:7718489-7743615 (+)
DBA/2J	MGP_DBA2J_G0024670	protein coding gene	Chr19:6833584-6858152 (+)
FVB/NJ	MGP_FVBNJ_G0024637	protein coding gene	Chr19:6867844-6892096 (+)
LP/J	MGP_LPJ_G0024757	protein coding gene	Chr19:7303148-7324416 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0024664	protein coding gene	Chr19:7621240-7642921 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025299	protein coding gene	Chr19:7120544-7140917 (+)
PWK/PhJ	MGP_PWKPhJ_G0023787	protein coding gene	Chr19:6257185-6294832 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0023592	protein coding gene	Chr19:6292080-6328558 (+)
WSB/EiJ	MGP_WSBEiJ_G0024104	protein coding gene	Chr19:6983340-7020290 (+)

Human Ortholog

RAB3IL1, RAB3A interacting protein like 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RAB3IL1, RAB3A interacting protein like 1
Synonyms

GRAB
Links

HGNC:9780

NCBI Gene ID: 5866

neXtProt AC: NX_Q8TBN0

UniProt: Q8TBN0
Chr Location

11q12.2-q12.3; chr11:61897301-61946323 (-) GRCh38

MGI Vertebrate Homology

Rab3il1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: RAB3IL1
Gene Tree

Rab3il1

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
7 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Endonuclease-mediated

3
Gene trapped

1
Targeted

3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

20 strains or lines available

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All GO Annotations

12
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

709
Tissues

3
cDNA Data

40
Literature Summary

2

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase rab3il1

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All Sequences

92
RefSeq

37
UniProt

6
CCDS

CCDS29569.1, CCDS84416.1, CCDS84417.1

Ensembl

ENSMUSG00000024663 (Evidence)
NCBI Gene

74760

			Length	Strain/Species	Flank
genomic	74760	NCBI Gene Model \| MGI Sequence Detail	36712	C57BL/6J	± kb
transcript	NM_001347429	RefSeq \| MGI Sequence Detail	3027	C57BL/6
polypeptide	Q8VDV3	UniProt \| EBI \| MGI Sequence Detail	383	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000013623 guanine nucleotide exchange factor for Rab-3A

(term hierarchy)
InterPro Domains

IPR009449 GDP/GTP exchange factor Sec2, N-terminal

IPR040351 Guanine nucleotide exchange factor RAB3IL/RAB3IP/Sec2

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All nucleic 40

cDNA 40

Microarray probesets 9

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MGI:2147474, MGI:2147776

Summaries

All 41

Developmental Gene Expression 2

Gene Ontology 6

Phenotypes 7
Earliest

J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
Latest

J:331552 Chen M, et al., Grab regulates transferrin receptor recycling and iron uptake in developing erythroblasts. Blood. 2022 Sep 8;140(10):1145-1155

TSS for Rab3il1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr155012	Chr19:9979056-9979067 (+)	29 bp
Tssr5440	Chr19:9979069-9979076 (+)	40 bp
Tssr155013	Chr19:9979082-9979096 (+)	56 bp
Tssr155014	Chr19:9992403-9992419 (+)	13,378 bp
Tssr155015	Chr19:9995584-9995601 (+)	16,560 bp
Tssr155016	Chr19:9995605-9995621 (+)	16,580 bp
Tssr155017	Chr19:9995629-9995640 (+)	16,602 bp
Tssr155018	Chr19:10000133-10000163 (+)	21,115 bp
Tssr155019	Chr19:10005828-10005841 (+)	26,802 bp
Tssr155020	Chr19:10012036-10012053 (+)	33,012 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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