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Ralgps1 Gene Detail
Summary
  • Symbol
    Ralgps1
  • Name
    Ral GEF with PH domain and SH3 binding motif 1
  • Synonyms
    5830418G11Rik, mKIAA0351, RALGEF2, RALGPS1A
  • Feature Type
    protein coding gene
  • IDs
    MGI:1922008
    NCBI Gene: 241308
  • Gene Overview
    MyGene.info: RALGPS1
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:33133417-33371486 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 22.25 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    706 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1922008
protein coding gene Chr2:33133417-33371512 (-)
129S1/SvImJ MGP_129S1SvImJ_G0025631
protein coding gene Chr2:31644144-31888937 (-)
A/J MGP_AJ_G0025608
protein coding gene Chr2:30294205-30534932 (-)
AKR/J MGP_AKRJ_G0025578
protein coding gene Chr2:31374600-31619462 (-)
BALB/cJ MGP_BALBcJ_G0025605
protein coding gene Chr2:30414522-30622412 (-)
C3H/HeJ MGP_C3HHeJ_G0025365
protein coding gene Chr2:31267486-31476408 (-)
C57BL/6NJ MGP_C57BL6NJ_G0026049
protein coding gene Chr2:32586209-32834333 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023458
protein coding gene Chr2:29023466-29236293 (-)
CAST/EiJ MGP_CASTEiJ_G0024827
protein coding gene Chr2:31233756-31477216 (-)
CBA/J MGP_CBAJ_G0025343
protein coding gene Chr2:33835076-34085831 (-)
DBA/2J MGP_DBA2J_G0025476
protein coding gene Chr2:30057267-30296457 (-)
FVB/NJ MGP_FVBNJ_G0025438
protein coding gene Chr2:29950171-30196255 (-)
LP/J MGP_LPJ_G0025562
protein coding gene Chr2:31531959-31786503 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0025469
protein coding gene Chr2:33435151-33649937 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0026107
protein coding gene Chr2:31258692-31503666 (-)
PWK/PhJ MGP_PWKPhJ_G0024575
protein coding gene Chr2:29973539-30214984 (-)
SPRET/EiJ MGP_SPRETEiJ_G0024375
protein coding gene Chr2:31420077-31678311 (-)
WSB/EiJ MGP_WSBEiJ_G0024896
protein coding gene Chr2:31445698-31687277 (-)



Homology
more
  • Human Ortholog
    RALGPS1, Ral GEF with PH domain and SH3 binding motif 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    RALGPS1, Ral GEF with PH domain and SH3 binding motif 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    RALGEF2, RALGPS1A
  • Links
    NCBI Gene ID: 9649
    neXtProt AC: NX_Q5JS13
    UniProt: Q5JS13

  • Chr Location
    9q33.3; chr9:126914774-127223166 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000038831 Ensembl Gene Model | MGI Sequence Detail 238070 C57BL/6J ±  kb
transcript ENSMUST00000091039 Ensembl | MGI Sequence Detail 2738 Not Applicable  
polypeptide ENSMUSP00000088563 Ensembl | MGI Sequence Detail 585 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000013699 ras-specific guanine nucleotide-releasing factor RalGPS1
  • PDB
  • InterPro Domains
    IPR011993 PH-like domain superfamily
    IPR001849 Pleckstrin homology domain
    IPR036964 Ras guanine-nucleotide exchange factor catalytic domain superfamily
    IPR023578 Ras guanine nucleotide exchange factor domain superfamily
    IPR001895 Ras guanine-nucleotide exchange factors catalytic domain
    IPR008937 Ras-like guanine nucleotide exchange factor
Molecular
Reagents
less
  • All nucleic 80
    Genomic 2
    cDNA 78

    Microarray probesets 4
Other
Accession IDs
less
MGI:2139099, MGI:2139101
References
more
  • Summaries
    All 32
    Gene Ontology 3
    Phenotypes 6
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
03/13/2019
MGI 6.13
The Jackson Laboratory