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Slamf8
Gene Detail
Symbol

Name
ID
Slamf8
SLAM family member 8
MGI:1921998
Synonyms
5830408F06Rik, Blame, SBBI42
Feature Type
protein coding gene
Genetic Map
Chromosome 1
79.99 cM, cytoband H2
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr1:172581758-172590568 bp, - strand
From VEGA annotation of GRCm38

  8811 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:10589  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle

HCOP human homology predictions: SLAMF8
Gene Tree: Slamf8

Human
homologs
SLAMF8, SLAM family member 8
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 56833
neXtProt AC: NX_Q9P0V8

Human Synonyms: BLAME, CD353, SBBI42

Human Chr (Location): 1q23.2; chr1:159826650-159837497 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Targeted(2)
Incidental mutations (data from APF , CvDC )
 
Mice homozygous for a knock-out allele exhibit increased Nox2 activity in macrophage.
 
Interactions
Slamf8 interacts with 147 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (10 annotations)
Process cellular response to drug, defense response to bacterium, ...
Component cell, integral component of membrane, ...
Function receptor activity
External Resources: FuncBase
Expression
cDNA source data(9)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase slamf8    NEW 
Molecular
reagents
All nucleic(9) cDNA(9)
Microarray probesets(2)
Other database
links
VEGA Gene Model OTTMUSG00000050153 (Evidence)
Ensembl Gene Model ENSMUSG00000053318 (Evidence)
Entrez Gene 74748 (Evidence)
UniGene 179812
DFCI TC1590744
DoTS DT.525953
NIA Mouse Gene Index U022075
Consensus CDS Project CCDS15517.1
International Mouse Phenotyping Consortium Status Slamf8
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000050153 VEGA Gene Model | MGI Sequence Detail 8811 C57BL/6J ±  kb
transcript OTTMUST00000127505 VEGA | MGI Sequence Detail 1659 Not Applicable 
polypeptide OTTMUSP00000068767 VEGA | MGI Sequence Detail 278 Not Applicable 

For the selected sequences
All sequences(28) RefSeq(4) UniProt(4)
Polymorphisms
SNPs within 2kb(208 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR015631 Signalling lymphocyte activation molecule family receptors
Protein Ontology PR:000014914 SLAM family member 8
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:188963 Wang G, et al., Cutting edge: Slamf8 is a negative regulator of Nox2 activity in macrophages. J Immunol. 2012 Jun 15;188(12):5829-32
All references(27)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/30/2015
MGI 5.22
The Jackson Laboratory