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Slamf8
Gene Detail
Symbol

Name
ID
Slamf8
SLAM family member 8
MGI:1921998
Synonyms
5830408F06Rik, Blame, SBBI42
Feature Type
protein coding gene
Genetic Map
Chromosome 1
79.99 cM, cytoband H2
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr1:172581377-172590568 bp, - strand
From Ensembl annotation of GRCm38

  9192 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:10589  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle

Gene Tree: Slamf8

Human
homologs
Human Homolog SLAMF8, SLAM family member 8
NCBI Gene ID 56833
neXtProt AC  NX_Q9P0V8
Human Synonyms  BLAME, CD353, SBBI42
Human Chr (Location)  1q23.2; chr1:159826650-159837492 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Targeted(2)
Incidental mutations (data from APF )
 
Mice homozygous for a knock-out allele exhibit increased Nox2 activity in macrophage.
 
Interactions
Slamf8 interacts with 148 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (11 annotations)
Process cellular response to drug, defense response to bacterium, ...
Component cell, integral component of membrane, ...
Function receptor activity
External Resources: FuncBase
Expression
cDNA source data(9)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(9) cDNA(9)
Microarray probesets(2)
Other database
links
Ensembl Gene ModelENSMUSG00000053318 (Evidence)
Entrez Gene74748 (Evidence)
UniGene179812
DFCITC1590744
DoTSDT.525953
NIA Mouse Gene IndexU022075
Consensus CDS ProjectCCDS15517.1
International Mouse Knockout Project StatusSlamf8
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000053318 Ensembl Gene Model | MGI Sequence Detail 9192 C57BL/6J ±  kb
transcript ENSMUST00000065679 Ensembl | MGI Sequence Detail 2040 Not Applicable 
polypeptide ENSMUSP00000067527 Ensembl | MGI Sequence Detail 278 Not Applicable 

For the selected sequences
All sequences(26) RefSeq(4) UniProt(7)
Polymorphisms
SNPs within 2kb(215 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR015631 Signalling lymphocyte activation molecule family receptors
Protein Ontology PR:000014914 SLAM family member 8
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:188963 Wang G, et al., Cutting edge: Slamf8 is a negative regulator of Nox2 activity in macrophages. J Immunol. 2012 Jun 15;188(12):5829-32
All references(28)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory