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Slamf8 Gene Detail
Summary
  • Symbol
    Slamf8
  • Name
    SLAM family member 8
  • Synonyms
    5830408F06Rik, Blame, SBBI42
  • Feature Type
    protein coding gene
  • IDs
    MGI:1921998
    NCBI Gene: 74748
  • Gene Overview
    MyGene.info: SLAMF8
  • Alliance
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:172581758-172590568 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 79.99 cM, cytoband H2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    209 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1921998
protein coding gene Chr1:172581377-172591191 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016793
protein coding gene Chr1:178455487-178466362 (-)
A/J MGP_AJ_G0016772
protein coding gene Chr1:171167983-171176737 (-)
AKR/J MGP_AKRJ_G0016738
protein coding gene Chr1:176328207-176338542 (-)
BALB/cJ MGP_BALBcJ_G0016733
protein coding gene Chr1:171698142-171706904 (-)
C3H/HeJ MGP_C3HHeJ_G0016557
protein coding gene Chr1:176901419-176910189 (-)
C57BL/6NJ MGP_C57BL6NJ_G0017195
protein coding gene Chr1:184381544-184391715 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014901
protein coding gene Chr1:162852723-162861735 (-)
CAST/EiJ MGP_CASTEiJ_G0016137
protein coding gene Chr1:176270241-176279687 (-)
CBA/J MGP_CBAJ_G0016531
protein coding gene Chr1:190932518-190945464 (-)
DBA/2J MGP_DBA2J_G0016638
protein coding gene Chr1:170085584-170094876 (-)
FVB/NJ MGP_FVBNJ_G0016635
protein coding gene Chr1:168345687-168354451 (-)
LP/J MGP_LPJ_G0016709
protein coding gene Chr1:179538807-179548971 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016662
protein coding gene Chr1:198162161-198172265 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017231
protein coding gene Chr1:176200367-176209096 (-)
PWK/PhJ MGP_PWKPhJ_G0015923
protein coding gene Chr1:169470142-169478954 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015705
protein coding gene Chr1:175157937-175166751 (-)
WSB/EiJ MGP_WSBEiJ_G0016199
protein coding gene Chr1:176349201-176359506 (-)



Homology
more
  • Human Ortholog
    SLAMF8, SLAM family member 8
  • Vertebrate Orthologs
    6
  • Human Ortholog
    SLAMF8, SLAM family member 8
    Orthology source: HomoloGene, HGNC
  • Synonyms
    BLAME, CD353, SBBI42
  • Links
    NCBI Gene ID: 56833
    neXtProt AC: NX_Q9P0V8
    UniProt: Q9P0V8

  • Chr Location
    1q23.2; chr1:159826650-159837497 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit increased Nox2 activity in macrophage.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000053318 Ensembl Gene Model | MGI Sequence Detail 8811 C57BL/6J ±  kb
transcript ENSMUST00000065679 Ensembl | MGI Sequence Detail 1659 Not Applicable  
polypeptide ENSMUSP00000067527 Ensembl | MGI Sequence Detail 278 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    4 Sequences
  • InterPro Domains
    IPR007110 Immunoglobulin-like domain
    IPR036179 Immunoglobulin-like domain superfamily
    IPR013783 Immunoglobulin-like fold
Molecular
Reagents
less
  • All nucleic 10
    cDNA 10

    Microarray probesets 2
References
more
  • Summaries
    All 26
    Gene Ontology 4
    Phenotypes 7
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:229624 Wang G, et al., Migration of myeloid cells during inflammation is differentially regulated by the cell surface receptors Slamf1 and Slamf8. PLoS One. 2015;10(3):e0121968

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory