About   Help   FAQ
Ddit4
Gene Detail
Symbol

Name
ID
Ddit4
DNA-damage-inducible transcript 4
MGI:1921997
Synonyms
5830413E08Rik, Dig2, REDD1, Rtp801
Feature Type
protein coding gene
Genetic Map
Chromosome 10
29.66 cM, cytoband B3
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr10:59949675-59951770 bp, - strand
From NCBI annotation of GRCm38

  2096 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:10400  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

Gene Tree: Ddit4

Human
homologs
Human Homolog DDIT4, DNA-damage-inducible transcript 4
NCBI Gene ID 54541
neXtProt AC  NX_Q9NX09
Human Synonyms  Dig2, REDD1, REDD-1
Human Chr (Location)  10q22.1; chr10:72273919-72276039 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Gene trapped(2) Targeted(5)
 
Homozygous null mice show resistance to hyperoxia-induced retinopathy. Mice homozygous for another knock-out allele exhibit normal testis development and fertility.
 
Interactions
Ddit4 interacts with 169 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (27 annotations)
Process apoptotic process, brain development, ...
Component cytoplasm, intracellular, ...
Function 14-3-3 protein binding
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (7)    Tissues (4)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 7
cDNA source data(98)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(100) Genomic(1) cDNA(99)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000020108 (Evidence)
Entrez Gene74747 (Evidence)
UniGene21697
DFCITC1574868
DoTSDT.531016, DT.91283366
NIA Mouse Gene IndexU031822
Consensus CDS ProjectCCDS23868.1
International Mouse Knockout Project StatusDdit4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 74747 NCBI Gene Model | MGI Sequence Detail 2096 C57BL/6J ±  kb
transcript NM_029083 RefSeq | MGI Sequence Detail 1685 C57BL/6 
polypeptide Q9D3F7 UniProt | EBI | MGI Sequence Detail 229 Not Applicable 

For the selected sequences
All sequences(21) RefSeq(2) UniProt(3)
Polymorphisms
SNPs within 2kb(20 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR012918 RTP801-like
Protein Ontology PR:000006348 DNA damage-inducible transcript 4 protein
Graphical View of Protein Domain Structure
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:213632 Nadon AM, et al., Rtp801 suppression of epithelial mTORC1 augments endotoxin-induced lung inflammation. Am J Pathol. 2014 Sep;184(9):2382-9
All references(54)
Other
accession IDs
MGI:2143476

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
11/18/2014
MGI 5.20
The Jackson Laboratory