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Ddit4
Gene Detail
Symbol

Name
ID
Ddit4
DNA-damage-inducible transcript 4
MGI:1921997
Synonyms
5830413E08Rik, Dig2, REDD1, Rtp801
Feature Type
protein coding gene
Genetic Map
Chromosome 10
29.66 cM, cytoband B3
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr10:59949675-59951770 bp, - strand
From NCBI annotation of GRCm38

  2096 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:10400  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: DDIT4
Gene Tree: Ddit4

Human
homologs
DDIT4, DNA-damage-inducible transcript 4
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 54541
neXtProt AC: NX_Q9NX09

Human Synonyms: Dig2, REDD1, REDD-1

Human Chr (Location): 10q22.1; chr10:72273919-72276039 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Gene trapped(2) Targeted(5)
Incidental mutations (data from CvDC )
 
Homozygous null mice show resistance to hyperoxia-induced retinopathy. Mice homozygous for another knock-out allele exhibit normal testis development and fertility.
 
Interactions
Ddit4 interacts with 169 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (27 annotations)
Process apoptotic process, brain development, ...
Component cytoplasm, intracellular, ...
Function 14-3-3 protein binding
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (7)    Tissues (4)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 7
cDNA source data(98)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase ddit4 ; ZFIN ddit4    NEW 
Molecular
reagents
All nucleic(100) Genomic(1) cDNA(99)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000020108 (Evidence)
Entrez Gene 74747 (Evidence)
UniGene 21697
DFCI TC1574868
DoTS DT.531016, DT.91283366
NIA Mouse Gene Index U031822
Consensus CDS Project CCDS23868.1
International Mouse Phenotyping Consortium Status Ddit4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 74747 NCBI Gene Model | MGI Sequence Detail 2096 C57BL/6J ±  kb
transcript NM_029083 RefSeq | MGI Sequence Detail 1685 C57BL/6 
polypeptide Q9D3F7 UniProt | EBI | MGI Sequence Detail 229 Not Applicable 

For the selected sequences
All sequences(20) RefSeq(2) UniProt(2)
Polymorphisms
SNPs within 2kb(20 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR012918 RTP801-like
Protein Ontology PR:000006348 DNA damage-inducible transcript 4 protein
Graphical View of Protein Domain Structure
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:220295 Dungan CM, et al., Lack of REDD1 reduces whole body glucose and insulin tolerance, and impairs skeletal muscle insulin signaling. Biochem Biophys Res Commun. 2014 Oct 31;453(4):778-83
All references(56)
Other
accession IDs
MGI:2143476

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory