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Shpk Gene Detail
Summary
  • Symbol
    Shpk
  • Name
    sedoheptulokinase
  • Synonyms
    4930431K22Rik, Carkl
  • Feature Type
    protein coding gene
  • IDs
    MGI:1921887
    NCBI Gene: 74637
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:73199460-73224511 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 45.25 cM, cytoband B4
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    158 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1921887
protein coding gene Chr11:73199132-73224511 (+)
129S1/SvImJ MGP_129S1SvImJ_G0018657
protein coding gene Chr11:73880703-73907070 (+)
A/J MGP_AJ_G0018625
protein coding gene Chr11:71107901-71134278 (+)
AKR/J MGP_AKRJ_G0018594
protein coding gene Chr11:73282350-73307219 (+)
BALB/cJ MGP_BALBcJ_G0018597
protein coding gene Chr11:71409836-71434653 (+)
C3H/HeJ MGP_C3HHeJ_G0018410
protein coding gene Chr11:73231807-73257669 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019048
protein coding gene Chr11:76130836-76156158 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016691
protein coding gene Chr11:67912539-67938416 (+)
CAST/EiJ MGP_CASTEiJ_G0017965
protein coding gene Chr11:73615279-73642763 (+)
CBA/J MGP_CBAJ_G0018382
protein coding gene Chr11:79479074-79503943 (+)
DBA/2J MGP_DBA2J_G0018491
protein coding gene Chr11:70734970-70759849 (+)
FVB/NJ MGP_FVBNJ_G0018482
protein coding gene Chr11:70280897-70305632 (+)
LP/J MGP_LPJ_G0018562
protein coding gene Chr11:74396008-74421923 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0018505
protein coding gene Chr11:79994067-80019850 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019090
protein coding gene Chr11:73462784-73487726 (+)
PWK/PhJ MGP_PWKPhJ_G0017738
protein coding gene Chr11:71375436-71401974 (+)
SPRET/EiJ MGP_SPRETEiJ_G0017528
protein coding gene Chr11:73176943-73204911 (+)
WSB/EiJ MGP_WSBEiJ_G0018019
protein coding gene Chr11:73213282-73239273 (+)



Homology
more
  • Human Ortholog
    SHPK, sedoheptulokinase
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SHPK, sedoheptulokinase
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CARKL, SHK
  • Links
    NCBI Gene ID: 23729
    neXtProt AC: NX_Q9UHJ6
    UniProt: Q9UHJ6

  • Chr Location
    17p13.2; chr17:3608262-3636322 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 8319
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: SHPK
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000005951 Ensembl Gene Model | MGI Sequence Detail 25052 C57BL/6J ±  kb
transcript ENSMUST00000006105 Ensembl | MGI Sequence Detail 2808 Not Applicable  
polypeptide ENSMUSP00000006105 Ensembl | MGI Sequence Detail 476 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    2 Sequences
  • EC
  • InterPro Domains
    IPR018484 Carbohydrate kinase, FGGY, N-terminal
Molecular
Reagents
less
  • All nucleic 33
    cDNA 33

    Microarray probesets 3
Other
Accession IDs
less
MGI:2144081, MGI:2144522
References
more
  • Summaries
    All 42
    Developmental Gene Expression 1
    Gene Ontology 8
    Phenotypes 12
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:185274 Haschemi A, et al., The Sedoheptulose Kinase CARKL Directs Macrophage Polarization through Control of Glucose Metabolism. Cell Metab. 2012 Jun 6;15(6):813-26

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
03/13/2019
MGI 6.13
The Jackson Laboratory