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Shpk Gene Detail
Summary
  • Symbol
    Shpk
  • Name
    sedoheptulokinase
  • Synonyms
    4930431K22Rik, Carkl
  • Feature Type
    protein coding gene
  • IDs
    MGI:1921887
    NCBI Gene: 74637
Location & Maps
more
  • Sequence Map
    Chr11:73199460-73224511 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      25052 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 45.25 cM, cytoband B4
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    SHPK, sedoheptulokinase
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SHPK, sedoheptulokinase
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CARKL, SHK
  • Links
    NCBI Gene ID: 23729
    neXtProt AC: NX_Q9UHJ6

  • Chr Location
    17p13; chr17:3608262-3636322 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 8319
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: SHPK
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotype references
  • All Mutations and Alleles
    5
  • Chemically induced (other)
    1
  • Targeted
    4
  • Genomic Mutations
    2 involving Shpk
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006126 VEGA Gene Model | MGI Sequence Detail 25052 C57BL/6J ±  kb
transcript OTTMUST00000013857 VEGA | MGI Sequence Detail 2808 Not Applicable  
polypeptide OTTMUSP00000006430 VEGA | MGI Sequence Detail 476 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    158 from dbSNP Build 142
Protein
Information
less
  • UniProt
    2 Sequences
  • EC
  • InterPro Domains
    IPR018484 Carbohydrate kinase, FGGY, N-terminal
Molecular
Reagents
less
  • All nucleic 32
    cDNA 32

    Microarray probesets 3
Other
Accession IDs
less
MGI:2144081, MGI:2144522
References
more
  • Summaries
    All 31
    Developmental Gene Expression 1
    Gene Ontology 6
    Phenotypes 11
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:185274 Haschemi A, et al., The Sedoheptulose Kinase CARKL Directs Macrophage Polarization through Control of Glucose Metabolism. Cell Metab. 2012 Jun 6;15(6):813-26

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory