Kcnk16 MGI Mouse Gene Detail - MGI:1921821 - potassium channel, subfamily K, member 16

Symbol

Kcnk16
Name

potassium channel, subfamily K, member 16
Synonyms

4731413G05Rik, TALK1, TALK-1

Feature Type

protein coding gene
IDs

MGI:1921821
NCBI Gene: 74571
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr14:20311444-20319267 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 14, 11.49 cM, cytoband B
Mapping Data

2 experiments

SNPs within 2kb

93 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1921821	protein coding gene	Chr14:20311443-20319337 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0021029	protein coding gene	Chr14:13015091-13021470 (-)
A/J	MGP_AJ_G0020978	protein coding gene	Chr14:12716235-12723056 (-)
AKR/J	MGP_AKRJ_G0020955	protein coding gene	Chr14:13234979-13241370 (-)
BALB/cJ	MGP_BALBcJ_G0020981	protein coding gene	Chr14:12829165-12835632 (-)
C3H/HeJ	MGP_C3HHeJ_G0020765	protein coding gene	Chr14:13174019-13180398 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0021414	protein coding gene	Chr14:13515024-13521413 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018982	protein coding gene	Chr14:13028465-13034638 (-)
CAST/EiJ	MGP_CASTEiJ_G0020289	protein coding gene	Chr14:12925397-12931576 (-)
CBA/J	MGP_CBAJ_G0020731	protein coding gene	Chr14:14196216-14202611 (-)
DBA/2J	MGP_DBA2J_G0020854	protein coding gene	Chr14:12547153-12553521 (-)
FVB/NJ	MGP_FVBNJ_G0020837	protein coding gene	Chr14:12443884-12450251 (-)
LP/J	MGP_LPJ_G0020930	protein coding gene	Chr14:13229031-13235427 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020863	protein coding gene	Chr14:13982396-13988771 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021447	protein coding gene	Chr14:13030290-13036570 (-)
PWK/PhJ	MGP_PWKPhJ_G0020038	protein coding gene	Chr14:12104286-12110797 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0019860	protein coding gene	Chr14:12800721-12807151 (-)
WSB/EiJ	MGP_WSBEiJ_G0020345	protein coding gene	Chr14:13011572-13017936 (-)

Human Ortholog

KCNK16, potassium two pore domain channel subfamily K member 16

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

KCNK16, potassium two pore domain channel subfamily K member 16
Synonyms

K2p16.1, TALK1, TALK-1
Links

HGNC:14464

NCBI Gene ID: 83795

neXtProt AC: NX_Q96T55

UniProt: Q96T55
Chr Location

6p21.2; chr6:39314570-39322968 (-) GRCh38

MGI Vertebrate Homology

Kcnk16 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: KCNK16
Protein SuperFamily

K_channel_subfamily_K_type
Gene Tree

Kcnk16

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Phenotype Summary

4 phenotypes from 2 alleles in 2 genetic backgrounds
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Endonuclease-mediated

2
Targeted

5
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

13 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit altered beta cell electrical excitability, second-phase insulin secretion and glucose homeostasis.

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All GO Annotations

7
GO References

2

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

4

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase kcnk16

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All Sequences

29
RefSeq

2
UniProt

2
CCDS

CCDS49407.1

Ensembl

ENSMUSG00000023387 (Evidence)
NCBI Gene

74571

			Length	Strain/Species	Flank
genomic	ENSMUSG00000023387	Ensembl Gene Model \| MGI Sequence Detail	7824	C57BL/6J	± kb
transcript	ENSMUST00000024155	Ensembl \| MGI Sequence Detail	916	Not Applicable
polypeptide	ENSMUSP00000024155	Ensembl \| MGI Sequence Detail	292	Not Applicable

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UniProt

2 Sequences
InterPro Domains

IPR013099 Potassium channel domain

IPR003280 Two pore domain potassium channel

IPR003092 Two pore domain potassium channel, TASK family

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All nucleic 6

Genomic 2

cDNA 4

Microarray probesets 2

Summaries

All 33

Gene Ontology 2

Phenotypes 12
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:344958 Graff SM, et al., TALK-1-mediated alterations of beta-cell mitochondrial function and insulin secretion impair glucose homeostasis on a diabetogenic diet. Cell Rep. 2024 Jan 23;43(1):113673

TSS for Kcnk16:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr127600	Chr14:20319321-20319343 (-)	-65 bp
Tssr127599	Chr14:20319241-20319312 (-)	-10 bp
Tssr127598	Chr14:20313501-20313528 (-)	5,752 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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