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Kcnk16 Gene Detail
Summary
  • Symbol
    Kcnk16
  • Name
    potassium channel, subfamily K, member 16
  • Synonyms
    4731413G05Rik, TALK1, TALK-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1921821
    NCBI Gene: 74571
  • Gene Overview
    MyGene.info: KCNK16
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:20262756-20269162 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 11.49 cM, cytoband B
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    83 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1921821
protein coding gene Chr14:20261376-20269199 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021029
protein coding gene Chr14:13015091-13021470 (-)
A/J MGP_AJ_G0020978
protein coding gene Chr14:12716235-12723056 (-)
AKR/J MGP_AKRJ_G0020955
protein coding gene Chr14:13234979-13241370 (-)
BALB/cJ MGP_BALBcJ_G0020981
protein coding gene Chr14:12829165-12835632 (-)
C3H/HeJ MGP_C3HHeJ_G0020765
protein coding gene Chr14:13174019-13180398 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021414
protein coding gene Chr14:13515024-13521413 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018982
protein coding gene Chr14:13028465-13034638 (-)
CAST/EiJ MGP_CASTEiJ_G0020289
protein coding gene Chr14:12925397-12931576 (-)
CBA/J MGP_CBAJ_G0020731
protein coding gene Chr14:14196216-14202611 (-)
DBA/2J MGP_DBA2J_G0020854
protein coding gene Chr14:12547153-12553521 (-)
FVB/NJ MGP_FVBNJ_G0020837
protein coding gene Chr14:12443884-12450251 (-)
LP/J MGP_LPJ_G0020930
protein coding gene Chr14:13229031-13235427 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020863
protein coding gene Chr14:13982396-13988771 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021447
protein coding gene Chr14:13030290-13036570 (-)
PWK/PhJ MGP_PWKPhJ_G0020038
protein coding gene Chr14:12104286-12110797 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019860
protein coding gene Chr14:12800721-12807151 (-)
WSB/EiJ MGP_WSBEiJ_G0020345
protein coding gene Chr14:13011572-13017936 (-)



Homology
more
  • Human Ortholog
    KCNK16, potassium two pore domain channel subfamily K member 16
  • Vertebrate Orthologs
    9
  • Human Ortholog
    KCNK16, potassium two pore domain channel subfamily K member 16
    Orthology source: HomoloGene, HGNC
  • Synonyms
    K2p16.1, TALK1, TALK-1
  • Links
    NCBI Gene ID: 83795
    neXtProt AC: NX_Q96T55
    UniProt: Q96T55

  • Chr Location
    6p21.2; chr6:39314566-39322992 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit altered beta cell electrical excitability, second-phase insulin secretion and glucose homeostasis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 74571 NCBI Gene Model | MGI Sequence Detail 6407 C57BL/6J ±  kb
transcript NM_029006 RefSeq | MGI Sequence Detail 879 C57BL/6  
polypeptide NP_083282 RefSeq | MGI Sequence Detail 292 C57BL/6  
For the selected sequence
Protein
Information
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  • UniProt
    2 Sequences
  • InterPro Domains
    IPR013099 Potassium channel domain
    IPR003280 Two pore domain potassium channel
    IPR003092 Two pore domain potassium channel, TASK family
Molecular
Reagents
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  • All nucleic 6
    Genomic 2
    cDNA 4

    Microarray probesets 2
References
more
  • Summaries
    All 28
    Gene Ontology 3
    Phenotypes 7
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:259519 Vierra NC, et al., TALK-1 channels control beta cell endoplasmic reticulum Ca(2+) homeostasis. Sci Signal. 2017 Sep 19;10(497)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory