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Nkx6-3 Gene Detail
Summary
  • Symbol
    Nkx6-3
  • Name
    NK6 homeobox 3
  • Synonyms
    9130417I07Rik, Nkx6.3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1921811
    NCBI Gene: 74561
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:23153271-23158948 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 11.42 cM, cytoband A3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    24 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1921811
protein coding gene Chr8:23153269-23158948 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033462
protein coding gene Chr8:21051901-21057588 (+)
A/J MGP_AJ_G0033442
protein coding gene Chr8:20352377-20358079 (+)
AKR/J MGP_AKRJ_G0033367
protein coding gene Chr8:21020781-21026462 (+)
BALB/cJ MGP_BALBcJ_G0033438
protein coding gene Chr8:20475240-20480937 (+)
C3H/HeJ MGP_C3HHeJ_G0033152
protein coding gene Chr8:21221061-21226741 (+)
C57BL/6NJ MGP_C57BL6NJ_G0033954
protein coding gene Chr8:21915957-21921633 (+)
CAROLI/EiJ no annotation
CAST/EiJ MGP_CASTEiJ_G0032478
protein coding gene Chr8:20654225-20659931 (+)
CBA/J MGP_CBAJ_G0033127
protein coding gene Chr8:22797059-22802740 (+)
DBA/2J MGP_DBA2J_G0033282
protein coding gene Chr8:20320737-20326418 (+)
FVB/NJ MGP_FVBNJ_G0033226
protein coding gene Chr8:20120313-20125994 (+)
LP/J MGP_LPJ_G0033371
protein coding gene Chr8:21044042-21049732 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033269
protein coding gene Chr8:22359911-22365598 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0033973
protein coding gene Chr8:20927163-20932857 (+)
PWK/PhJ MGP_PWKPhJ_G0032190
protein coding gene Chr8:19914904-19920649 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032023
protein coding gene Chr8:20301577-20307850 (+)
WSB/EiJ MGP_WSBEiJ_G0032594
protein coding gene Chr8:21134235-21139918 (+)



Homology
more
  • Human Ortholog
    NKX6-3, NK6 homeobox 3
  • Vertebrate Orthologs
    8
  • Human Ortholog
    NKX6-3, NK6 homeobox 3
    Orthology source: HGNC
  • Synonyms
    NKX6.3
  • Links
    NCBI Gene ID: 157848
    neXtProt AC: NX_A6NJ46
    UniProt: A6NJ46

  • Chr Location
    8p11.21; chr8:41645177-41650818 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit a significantly decreased number of gastrin-producing (G) cells in the stomach antrum, hypogastrinemia, and increased stomach luminal pH, with a corresponding increase in antral somatostatin-producing (D) cells.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 74561 NCBI Gene Model | MGI Sequence Detail 5678 C57BL/6J ±  kb
    transcript NM_029002 RefSeq | MGI Sequence Detail 2236 C57BL/6  
    polypeptide Q3UHX8 UniProt | EBI | MGI Sequence Detail 262 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 11
      cDNA 8
      Primer pair 1
      Other 2

      Microarray probesets 2
    References
    more
    • Summaries
      All 35
      Developmental Gene Expression 10
      Gene Ontology 4
      Phenotypes 6
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:215487 Thompson CL, et al., A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. Neuron. 2014 Jul 16;83(2):309-23

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    last database update
    10/08/2019
    MGI 6.14
    The Jackson Laboratory