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Gsdmc4 Gene Detail
Summary
  • Symbol
    Gsdmc4
  • Name
    gasdermin C4
  • Synonyms
    9030605I04Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1921798
    NCBI Gene: 74548
  • Alliance
Location &
Maps
more
  • Sequence Map
    Chr15:63891264-63912297 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 28.07 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    32 from dbSNP Build 142
  • Strain Annotations
    11
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1921798
protein coding gene Chr15:63889945-63912308 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021892
protein coding gene Chr15:63214095-63332088 (-)
A/J MGP_AJ_G0021853
protein coding gene Chr15:60877270-60915384 (-)
AKR/J no annotation
BALB/cJ MGP_BALBcJ_G0021860
protein coding gene Chr15:61022266-61043451 (-)
C3H/HeJ no annotation
C57BL/6NJ MGP_C57BL6NJ_G0022299
protein coding gene Chr15:65603182-65798341 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019837
protein coding gene Chr15:57735607-57762532 (-)
CAST/EiJ MGP_CASTEiJ_G0021152
protein coding gene Chr15:63353595-63365784 (-)
CBA/J no annotation
DBA/2J no annotation
FVB/NJ MGP_FVBNJ_G0021704
protein coding gene Chr15:59630377-59665905 (-)
LP/J no annotation
NOD/ShiLtJ MGP_NODShiLtJ_G0021727
protein coding gene Chr15:72915397-72974038 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022319
protein coding gene Chr15:62903828-62925642 (-)
PWK/PhJ no annotation
SPRET/EiJ MGP_SPRETEiJ_G0020733
protein coding gene Chr15:62823487-62841389 (-)
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    GSDMC, gasdermin C
  • Vertebrate Orthologs
    10
  • Human Ortholog
    GSDMC, gasdermin C
    Orthology source: HomoloGene, HGNC
  • Synonyms
    MLZE
  • Links
    NCBI Gene ID: 56169
    neXtProt AC: NX_Q9BYG8
    UniProt: Q9BYG8

  • Chr Location
    8q24.21; chr8:129705903-129786888 (-)  GRCh38.p7

Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    22 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000055748 Ensembl Gene Model | MGI Sequence Detail 21034 C57BL/6J ±  kb
transcript ENSMUST00000188108 Ensembl | MGI Sequence Detail 2085 Not Applicable  
polypeptide ENSMUSP00000140269 Ensembl | MGI Sequence Detail 480 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 4
    cDNA 4

    Microarray probesets 2
References
more
  • Summaries
    All 44
    Developmental Gene Expression 5
    Diseases 1
    Gene Ontology 3
    Phenotypes 22
  • Earliest
    J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
  • Latest
    J:241013 Grassmeyer J, et al., Elf5 is a principal cell lineage specific transcription factor in the kidney that contributes to Aqp2 and Avpr2 gene expression. Dev Biol. 2017 Apr 01;424(1):77-89

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
10/08/2019
MGI 6.14
The Jackson Laboratory