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Mgme1 Gene Detail
Summary
  • Symbol
    Mgme1
  • Name
    mitochondrial genome maintainance exonuclease 1
  • Synonyms
    8430406I07Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1921778
    NCBI Gene: 74528
Location & Maps
more
  • Sequence Map
    Chr2:144270663-144281227 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      10565 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    MGME1, mitochondrial genome maintenance exonuclease 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    MGME1, mitochondrial genome maintenance exonuclease 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    bA504H3.4, C20orf72, DDK1, MTDPS11
  • Links
    NCBI Gene ID: 92667
    neXtProt AC: NX_Q9BQP7

  • Chr Location
    20p11.23; chr20:17968853-17991122 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 12573
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: MGME1
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human MGME1 associations

Human Disease Mouse Models
       Mitochondrial DNA Depletion Syndrome 11; MTDPS11   OMIM: 615084
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    10 phenotype references
  • All Mutations and Alleles
    128
  • Chemically induced (other)
    1
  • Gene trapped
    124
  • Radiation induced
    1
  • Targeted
    2
  • Genomic Mutations
    2 involving Mgme1
  • Incidental Mutations
    APF
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000003459 VEGA Gene Model | MGI Sequence Detail 10565 C57BL/6J ±  kb
transcript OTTMUST00000007325 VEGA | MGI Sequence Detail 2308 Not Applicable  
polypeptide OTTMUSP00000003534 VEGA | MGI Sequence Detail 338 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    154 from dbSNP Build 142
Protein
Information
less
  • UniProt
    1 Sequence
  • EC
  • InterPro Domains
    IPR026970 Mitochondrial genome maintenance exonuclease 1
Molecular
Reagents
less
  • All nucleic 54
    cDNA 54

    Microarray probesets 4
Other
Accession IDs
less
MGI:2138936
References
more
  • Summaries
    All 33
    Gene Ontology 6
    Phenotypes 10
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:151002 Pagliarini DJ, et al., A mitochondrial protein compendium elucidates complex I disease biology. Cell. 2008 Jul 11;134(1):112-23

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory