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Mgme1
Gene Detail
 Symbol
Name
ID
Mgme1
mitochondrial genome maintainance exonuclease 1
MGI:1921778
Synonyms 8430406I07Rik
Feature Type protein coding gene
Genetic Map
Chromosome 2
70.98 cM, cytoband H1
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr2:144270663-144281227 bp, + strand
From VEGA annotation of GRCm38

  10565 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:12573  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Mgme1

Human
homologs
Human Homolog MGME1, mitochondrial genome maintenance exonuclease 1
NCBI Gene ID 92667
neXtProt AC  NX_Q9BQP7
Human Synonyms  bA504H3.4, C20orf72, DDK1, MTDPS11
Human Chr (Location)  20p11.23; chr20:17968943-17991122 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human MGME1
Mutations,
alleles, and
phenotypes
All mutations/alleles(126) : Gene trapped(124) Targeted(2)
Incidental mutations (data from APF )
Interactions
Mgme1 interacts with 189 markers (Mir1b, Mir7-1, Mir15b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (20 annotations)
Process cellular response to DNA damage stimulus, DNA catabolic process, exonucleolytic, ...
Component mitochondrion
Function exonuclease activity, hydrolase activity, ...
External Resources: FuncBase
Expression
cDNA source data(54)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(54) cDNA(54)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000003459 (Evidence)
Ensembl Gene ModelENSMUSG00000027424 (Evidence)
Entrez Gene74528 (Evidence)
UniGene386817
DFCITC1579323, TC1690376
DoTSDT.531162, DT.87049939, DT.97355510, DT.99852383
NIA Mouse Gene IndexU002567
EC3.1.-.-
Consensus CDS ProjectCCDS16816.1
International Mouse Knockout Project StatusMgme1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000003459 VEGA Gene Model | MGI Sequence Detail 10565 C57BL/6J ±  kb
transcript OTTMUST00000009533 VEGA | MGI Sequence Detail 2359 Not Applicable 
polypeptide OTTMUSP00000004626 VEGA | MGI Sequence Detail 338 Not Applicable 

For the selected sequences
All sequences(46) RefSeq(8) UniProt(1)
Polymorphisms SNPs within 2kb(155 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR026970 Uncharacterised protein C20orf72
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:151002 Pagliarini DJ, et al., A mitochondrial protein compendium elucidates complex I disease biology. Cell. 2008 Jul 11;134(1):112-23
All references(37)
Other
accession IDs
MGI:2138936

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory