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Cdkal1
Gene Detail
Symbol

Name
ID
Cdkal1
CDK5 regulatory subunit associated protein 1-like 1
MGI:1921765
Synonyms
1190005B03Rik, 6620401C13Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 13
12.93 cM, cytoband A3.3
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr13:29191746-29855674 bp, - strand
From VEGA annotation of GRCm38

  663929 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:9830  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Cdkal1

Human
homologs
Human Homolog CDKAL1, CDK5 regulatory subunit associated protein 1-like 1
NCBI Gene ID 54901
neXtProt AC  NX_Q5VV42
Human Chr (Location)  6p22.3; chr6:20534457-21232404 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human CDKAL1
Mutations,
alleles, and
phenotypes
All mutations/alleles(30) : Gene trapped(22) Radiation induced(1) Targeted(7)
Genomic Mutations involving Cdkal1 (1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a targeted allele exhibit impaired tRNALys modification. Mice homozygous for a gene trap allele exhibit altered glucose homeostasis and lipid accumulation at early stages when fed a high fat diet.
 
Human Diseases Modeled Using Mouse Cdkal1 (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(2)
Interactions
Cdkal1 interacts with 259 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (4 records)
Data Summary: Results (21)    Tissues (5)    Images (1)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 1
RT-PCR 20
cDNA source data(26)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(27) cDNA(26) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000000663 (Evidence)
Ensembl Gene ModelENSMUSG00000006191 (Evidence)
Entrez Gene68916 (Evidence)
UniGene212227
DFCITC1644610, TC1614951, TC1593824, TC1579369
DoTSDT.101710716, DT.101718484, DT.87053358, DT.110967154, DT.50315955, DT.101143456
NIA Mouse Gene IndexU034653
EC2.8.4.5
Consensus CDS ProjectCCDS26412.1
International Mouse Knockout Project StatusCdkal1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000000663 VEGA Gene Model | MGI Sequence Detail 663929 C57BL/6J ±  kb
transcript OTTMUST00000001282 VEGA | MGI Sequence Detail 2629 Not Applicable 
polypeptide OTTMUSP00000000607 VEGA | MGI Sequence Detail 578 Not Applicable 

For the selected sequences
All sequences(82) RefSeq(12) UniProt(9)
Polymorphisms
SNPs within 2kb(3006 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006638 Elongator protein 3/MiaB/NifB
InterPro IPR005839 Methylthiotransferase
InterPro IPR020612 Methylthiotransferase, conserved site
InterPro IPR013848 Methylthiotransferase, N-terminal
InterPro IPR023970 Methylthiotransferase/radical SAM-type protein
InterPro IPR006466 MiaB-like tRNA modifying enzyme, archaeal-type
InterPro IPR007197 Radical SAM
InterPro IPR023404 Radical SAM, alpha/beta horseshoe
InterPro IPR002792 TRAM domain
Protein Ontology PR:000005268 threonylcarbamoyladenosine tRNA methylthiotransferase
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:195460 Okamura T, et al., Deletion of CDKAL1 affects high-fat diet-induced fat accumulation and glucose-stimulated insulin secretion in mice, indicating relevance to diabetes. PLoS One. 2012;7(11):e49055
All references(40)
Disease annotation references (1)
Other
accession IDs
MGI:1916166

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory