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Cdkal1 Gene Detail
Summary
  • Symbol
    Cdkal1
  • Name
    CDK5 regulatory subunit associated protein 1-like 1
  • Synonyms
    1190005B03Rik, 6620401C13Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1921765
    NCBI Gene: 68916
  • Gene Overview
    MyGene.info: CDKAL1
Location & Maps
more
  • Sequence Map
    Chr13:29191746-29855674 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      663929 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 13, 12.93 cM, cytoband A3.3
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    CDKAL1, CDK5 regulatory subunit associated protein 1 like 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    CDKAL1, CDK5 regulatory subunit associated protein 1 like 1
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 54901
    neXtProt AC: NX_Q5VV42

  • Chr Location
    6p22.3; chr6:20534457-21232404 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Cdkal1 mouse models; 1 with human CDKAL1 associations

Human Disease Mouse Models
       Diabetes Mellitus, Noninsulin-Dependent; NIDDM   OMIM: 125853 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    25 phenotypes from 6 alleles in 7 genetic backgrounds
    2 images
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    32
  • Chemically induced (other)
    1
  • Gene trapped
    22
  • Radiation induced
    1
  • Targeted
    7
  • Transgenic
    1
  • Genomic Mutations
    2 involving Cdkal1
  • Incidental Mutations
Mice homozygous for a targeted allele exhibit impaired tRNALys modification. Mice homozygous for a gene trap allele exhibit altered glucose homeostasis and lipid accumulation at early stages when fed a high fat diet.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000000663 VEGA Gene Model | MGI Sequence Detail 663929 C57BL/6J ±  kb
transcript OTTMUST00000001282 VEGA | MGI Sequence Detail 2629 Not Applicable  
polypeptide OTTMUSP00000000607 VEGA | MGI Sequence Detail 578 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    3001 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 27
    cDNA 26
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
less
MGI:1916166
References
more
  • Summaries
    All 38
    Developmental Gene Expression 4
    Diseases 1
    Gene Ontology 7
    Phenotypes 19
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:195460 Okamura T, et al., Deletion of CDKAL1 affects high-fat diet-induced fat accumulation and glucose-stimulated insulin secretion in mice, indicating relevance to diabetes. PLoS One. 2012;7(11):e49055

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory