About   Help   FAQ
Neto2 Gene Detail
Summary
  • Symbol
    Neto2
  • Name
    neuropilin (NRP) and tolloid (TLL)-like 2
  • Synonyms
    5530601C23Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1921763
    NCBI Gene: 74513
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:85636588-85700919 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 41.61 cM, cytoband C4
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    314 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1921763
protein coding gene Chr8:85636588-85700924 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033904
protein coding gene Chr8:86587752-86654719 (-)
A/J MGP_AJ_G0033887
protein coding gene Chr8:83178477-83243605 (-)
AKR/J MGP_AKRJ_G0033813
protein coding gene Chr8:85654041-85720151 (-)
BALB/cJ MGP_BALBcJ_G0033880
protein coding gene Chr8:83320534-83384795 (-)
C3H/HeJ MGP_C3HHeJ_G0033591
protein coding gene Chr8:86277013-86341065 (-)
C57BL/6NJ MGP_C57BL6NJ_G0034401
protein coding gene Chr8:89929396-89992297 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031341
protein coding gene Chr8:76966080-77026666 (-)
CAST/EiJ MGP_CASTEiJ_G0032921
protein coding gene Chr8:85688401-85759876 (-)
CBA/J MGP_CBAJ_G0033566
protein coding gene Chr8:92976188-93045138 (-)
DBA/2J MGP_DBA2J_G0033719
protein coding gene Chr8:82815711-82878972 (-)
FVB/NJ MGP_FVBNJ_G0033667
protein coding gene Chr8:81760836-81825419 (-)
LP/J MGP_LPJ_G0033811
protein coding gene Chr8:86703971-86772241 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033710
protein coding gene Chr8:95498177-95568430 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0034418
protein coding gene Chr8:85638962-85706124 (-)
PWK/PhJ MGP_PWKPhJ_G0032625
protein coding gene Chr8:82058717-82127021 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032460
protein coding gene Chr8:84427050-84491656 (-)
WSB/EiJ MGP_WSBEiJ_G0033033
protein coding gene Chr8:86063475-86131424 (-)



Homology
more
  • Human Ortholog
    NETO2, neuropilin and tolloid like 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    NETO2, neuropilin and tolloid like 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    BTCL2, NEOT2
  • Links
    NCBI Gene ID: 81831
    neXtProt AC: NX_Q8NC67
    UniProt: Q8NC67

  • Chr Location
    16q12.1; chr16:47081520-47144025 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 32387
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: NETO2
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    1 phenotype from multigenic genotypes
    37 phenotype references
Mice homozygous for a null mutation show normal brain morphology and kainate receptor mediated excitatory postsynaptic currents.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 74513 NCBI Gene Model | MGI Sequence Detail 64332 C57BL/6J ±  kb
transcript NR_151665 RefSeq | MGI Sequence Detail 5694 C57BL/6  
polypeptide Q8BNJ6 UniProt | EBI | MGI Sequence Detail 525 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000011144 neuropilin and tolloid-like protein 2
  • InterPro Domains
    IPR000859 CUB domain
    IPR036055 LDL receptor-like superfamily
    IPR023415 Low-density lipoprotein (LDL) receptor class A, conserved site
    IPR002172 Low-density lipoprotein (LDL) receptor class A repeat
    IPR028868 Neuropilin and tolloid-like protein 2
    IPR035914 Spermadhesin, CUB domain superfamily
Molecular
Reagents
less
  • All nucleic 70
    cDNA 70

    Microarray probesets 4
Other
Accession IDs
less
MGI:2142645
References
more
  • Summaries
    All 71
    Developmental Gene Expression 8
    Gene Ontology 3
    Phenotypes 37
  • Earliest
    J:13049 Gruneberg H, Genetical studies on the skeleton of the mouse. XVIII. Three genes for syndactylism. J Genet. 1956;54:113-145
  • Latest
    J:266142 Grosjean F, et al., Pharmacologic control of oxidative stress and inflammation determines whether diabetic glomerulosclerosis progresses or decreases: A pilot study in sclerosis-prone mice. PLoS One. 2018;13(9):e0204366

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/13/2019
MGI 6.14
The Jackson Laboratory