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Taf7l Gene Detail
Summary
  • Symbol
    Taf7l
  • Name
    TATA-box binding protein associated factor 7 like
  • Synonyms
    4933438I11Rik, Taf2q
  • Feature Type
    protein coding gene
  • IDs
    MGI:1921719
    NCBI Gene: 74469
  • Alliance
Location & Maps
more
  • Sequence Map
    ChrX:134460118-134476490 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      16373 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome X, 56.18 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    TAF7L, TATA-box binding protein associated factor 7 like
  • Vertebrate Orthologs
    7
  • Human Ortholog
    TAF7L, TATA-box binding protein associated factor 7 like
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CT40, TAF2Q
  • Links
    NCBI Gene ID: 54457
    neXtProt AC: NX_Q5H9L4
    UniProt: Q5H9L4

  • Chr Location
    Xq22.1; chrX:101268253-101293071 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    21 phenotypes from 2 alleles in 4 genetic backgrounds
    3 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Targeted inactivation of this gene causes male subfertility, oligozoospermia, teratozoospermia, athenozoospermia, abnormal seminiferous tubules, and reduced testis weight on congenic but not on mixed strain backgrounds. Decreased brown fat tissue amount and enhanced skeletal muscle formation are also observed.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000019305 VEGA Gene Model | MGI Sequence Detail 16373 C57BL/6J ±  kb
    transcript OTTMUST00000046133 VEGA | MGI Sequence Detail 1933 Not Applicable  
    polypeptide OTTMUSP00000020831 VEGA | MGI Sequence Detail 471 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      30 from dbSNP Build 142
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • InterPro Domains
      IPR006751 TAFII55 protein, conserved region
      IPR037817 Transcription initiation factor TFIID subunit 7
    Molecular
    Reagents
    less
    • All nucleic 20
      cDNA 18
      Primer pair 2

      Microarray probesets 2
    References
    more
    • Summaries
      All 35
      Developmental Gene Expression 8
      Gene Ontology 6
      Phenotypes 3
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:230563 Kato Y, et al., Dazl is a target RNA suppressed by mammalian NANOS2 in sexually differentiating male germ cells. Nat Commun. 2016;7:11272

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    05/15/2018
    MGI 6.12
    The Jackson Laboratory