About   Help   FAQ
Pgs1 Gene Detail
Summary
  • Symbol
    Pgs1
  • Name
    phosphatidylglycerophosphate synthase 1
  • Synonyms
    2610019F11Rik, 4933424M23Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1921701
    NCBI Gene: 74451
  • Alliance
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:117877118-117914837 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 11, 82.96 cM, cytoband E2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    136 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1921701
protein coding gene Chr11:117876505-117914837 (+)
129S1/SvImJ MGP_129S1SvImJ_G0019460
protein coding gene Chr11:122289825-122330363 (+)
A/J MGP_AJ_G0019428
protein coding gene Chr11:116863449-116901987 (+)
AKR/J MGP_AKRJ_G0019398
protein coding gene Chr11:120416285-120453794 (+)
BALB/cJ MGP_BALBcJ_G0019403
protein coding gene Chr11:117231380-117268999 (+)
C3H/HeJ MGP_C3HHeJ_G0019209
protein coding gene Chr11:120711467-120751538 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019852
protein coding gene Chr11:126025947-126069117 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017477
protein coding gene Chr11:113874425-113912214 (+)
CAST/EiJ MGP_CASTEiJ_G0018763
protein coding gene Chr11:122130970-122168874 (+)
CBA/J MGP_CBAJ_G0019180
protein coding gene Chr11:130962475-131007254 (+)
DBA/2J MGP_DBA2J_G0019292
protein coding gene Chr11:116256785-116294523 (+)
FVB/NJ MGP_FVBNJ_G0019284
protein coding gene Chr11:115886248-115925462 (+)
LP/J MGP_LPJ_G0019362
protein coding gene Chr11:122610577-122648156 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019317
protein coding gene Chr11:129927571-129973382 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019891
protein coding gene Chr11:121069028-121108943 (+)
PWK/PhJ MGP_PWKPhJ_G0018529
protein coding gene Chr11:117622379-117660220 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018321
protein coding gene Chr11:120799804-120837229 (+)
WSB/EiJ MGP_WSBEiJ_G0018815
protein coding gene Chr11:121031627-121074554 (+)



Homology
more
  • Human Ortholog
    PGS1, phosphatidylglycerophosphate synthase 1
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PGS1, phosphatidylglycerophosphate synthase 1
  • Links
    NCBI Gene ID: 9489
    neXtProt AC: NX_Q32NB8
    UniProt: Q32NB8

  • Chr Location
    17q25.3; chr17:78378649-78425114 (+)  GRCh38

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000017715 Ensembl Gene Model | MGI Sequence Detail 37720 C57BL/6J ±  kb
    transcript ENSMUST00000132676 Ensembl | MGI Sequence Detail 2863 Not Applicable  
    polypeptide ENSMUSP00000121973 Ensembl | MGI Sequence Detail 553 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      6 Sequences
    • Protein Ontology
      PR:000012624 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial
    • EC
    • InterPro Domains
      IPR016270 CDP-alcohol phosphatidyltransferase class-II family
      IPR001736 Phospholipase D/Transphosphatidylase
    Molecular
    Reagents
    less
    • All nucleic 81
      cDNA 81

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:1919058
    References
    more
    • Summaries
      All 40
      Developmental Gene Expression 2
      Gene Ontology 5
      Phenotypes 11
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:236599 Dickinson ME, et al., High-throughput discovery of novel developmental phenotypes. Nature. 2016 Sep 14;537(7621):508-514

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.
    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory