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Pank2
Gene Detail
 Symbol
Name
ID
Pank2
pantothenate kinase 2
MGI:1921700
Synonyms 4933409I19Rik
Feature Type protein coding gene
Genetic Map
Chromosome 2
63.31 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr2:131262495-131299188 bp, + strand
From VEGA annotation of GRCm38

  36694 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:65126  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: pantothenate kinase, acetyl-CoA regulated, stand-alone type
Gene Tree: Pank2

Human
homologs
Human Homolog PANK2, pantothenate kinase 2
NCBI Gene ID 80025
neXtProt AC  NX_Q9BZ23
Human Synonyms  C20orf48, HARP, HSS, NBIA1, PKAN
Human Chr (Location)  20p13; chr20:3887610-3923891 (+)  GRCh38
Disease Associations  (2) Diseases Associated with Human PANK2
Alleles
and
phenotypes
All alleles(31) : Gene trapped(26) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice display male infertility, arrested spermatogenesis, azoospermia, reduced female fertility, and retinal degeneration.
 
Phenotype Images(3)
Gene Ontology
(GO)
classifications
All GO classifications: (15 annotations)
Process aerobic respiration, coenzyme A biosynthetic process, ...
Component cytosol, mitochondrion
Function kinase activity, pantothenate kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (94)    Tissues (94)   
Theiler Stages: 22
Assay TypeResults
RNA in situ 94
cDNA source data(12)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(14) Genomic(1) cDNA(13)
Microarray probesets(7)
Other database
links
VEGA Gene ModelOTTMUSG00000016043 (Evidence)
Ensembl Gene ModelENSMUSG00000037514 (Evidence)
Entrez Gene74450 (Evidence)
Consensus CDS ProjectCCDS16761.1
International Mouse Knockout Project StatusPank2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016043 VEGA Gene Model | MGI Sequence Detail 36694 C57BL/6J ±  kb
transcript OTTMUST00000038271 VEGA | MGI Sequence Detail 4266 Not Applicable 
polypeptide OTTMUSP00000017161 VEGA | MGI Sequence Detail 443 Not Applicable 

For the selected sequences
All sequences(72) RefSeq(10) UniProt(8)
Polymorphisms SNPs within 2kb(218 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004567 Type II pantothenate kinase
Protein Ontology PR:000012256 pantothenate kinase 2, mitochondrial
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:195468 Alfonso-Pecchio A, et al., Compartmentalization of mammalian pantothenate kinases. PLoS One. 2012;7(11):e49509
All references(40)
Other
accession IDs
MGI:2139023

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory