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Pank2
Gene Detail
Symbol

Name
ID
Pank2
pantothenate kinase 2
MGI:1921700
Synonyms
4933409I19Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 2
63.31 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr2:131262495-131299188 bp, + strand
From VEGA annotation of GRCm38

  36694 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:65126  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: PANK2
Protein SuperFamily: pantothenate kinase, acetyl-CoA regulated, stand-alone type
Gene Tree: Pank2

Human
homologs
PANK2, pantothenate kinase 2
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 80025
neXtProt AC: NX_Q9BZ23

Human Synonyms: C20orf48, HARP, HSS, NBIA1, PKAN

Human Chr (Location): 20p13; chr20:3888839-3923891 (+)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human PANK2

Mutations,
alleles, and
phenotypes
All mutations/alleles(31) : Gene trapped(26) Targeted(5)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous null mice display male infertility, arrested spermatogenesis, azoospermia, reduced female fertility, and retinal degeneration.
 
Phenotype Images(3)
Interactions
Pank2 interacts with 306 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process aerobic respiration, coenzyme A biosynthetic process, ...
Component cytosol, mitochondrion
Function pantothenate kinase activity
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (94)    Tissues (94)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 94
cDNA source data(12)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase LOC100487302    NEW 
Molecular
reagents
All nucleic(14) Genomic(1) cDNA(13)
Microarray probesets(7)
Other database
links
VEGA Gene Model OTTMUSG00000016043 (Evidence)
Ensembl Gene Model ENSMUSG00000037514 (Evidence)
Entrez Gene 74450 (Evidence)
Consensus CDS Project CCDS16761.1
International Mouse Phenotyping Consortium Status Pank2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016043 VEGA Gene Model | MGI Sequence Detail 36694 C57BL/6J ±  kb
transcript OTTMUST00000038271 VEGA | MGI Sequence Detail 4266 Not Applicable 
polypeptide OTTMUSP00000017161 VEGA | MGI Sequence Detail 443 Not Applicable 

For the selected sequences
All sequences(74) RefSeq(12) UniProt(8)
Polymorphisms
SNPs within 2kb(218 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004567 Type II pantothenate kinase
Protein Ontology PR:000012256 pantothenate kinase 2, mitochondrial
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:195468 Alfonso-Pecchio A, et al., Compartmentalization of mammalian pantothenate kinases. PLoS One. 2012;7(11):e49509
All references(38)
Disease annotation references (1)
Other
accession IDs
MGI:2139023

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory