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Sgms2
Gene Detail
Symbol

Name
ID
Sgms2
sphingomyelin synthase 2
MGI:1921692
Synonyms
4933405A16Rik, 5133401H06Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 3
60.91 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr3:131318985-131344940 bp, - strand
From VEGA annotation of GRCm38

  25956 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:32705  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: SGMS2
Gene Tree: Sgms2

Human
homologs
SGMS2, sphingomyelin synthase 2
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 166929
neXtProt AC: NX_Q8NHU3

Human Synonyms: SMS2

Human Chr (Location): 4q25; chr4:107824335-107915047 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a knock-out allele exhibit increased ceramide levels; decreased sphingomyelin, sphingomyelin-1-phosphate, and diacylglycerol levels; and resistance to lysenin-mediated cytolysis.
 
Phenotype Images(1)
Interactions
Sgms2 interacts with 408 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (19 annotations)
Process lipid metabolic process, phosphorylation, ...
Component Golgi apparatus, integral component of cell outer membrane, ...
Function ceramide cholinephosphotransferase activity, kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (225)    Tissues (114)    Images (32)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 225
cDNA source data(30)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase sgms2    NEW 
Molecular
reagents
All nucleic(30) cDNA(30)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000022630 (Evidence)
Ensembl Gene Model ENSMUSG00000050931 (Evidence)
Entrez Gene 74442 (Evidence)
UniGene 273360
DFCI TC1704893, TC1605505
DoTS DT.50316083, DT.40174947
NIA Mouse Gene Index U024659, U256874
EC 2.7.8.27
Consensus CDS Project CCDS17843.1
International Mouse Phenotyping Consortium Status Sgms2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022630 VEGA Gene Model | MGI Sequence Detail 25956 C57BL/6J ±  kb
transcript OTTMUST00000054212 VEGA | MGI Sequence Detail 5801 Not Applicable 
polypeptide OTTMUSP00000025844 VEGA | MGI Sequence Detail 365 Not Applicable 

For the selected sequences
All sequences(40) RefSeq(16) UniProt(2)
Polymorphisms
SNPs within 2kb(143 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR025749 Sphingomyelin synthase-like domain
Protein Ontology PR:000014797 phosphatidylcholine:ceramide cholinephosphotransferase 2
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:220024 Ding T, et al., All members in the sphingomyelin synthase gene family have ceramide phosphoethanolamine synthase activity. J Lipid Res. 2015 Mar;56(3):537-45
All references(49)
Other
accession IDs
MGI:1918555, MGI:2139836

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory