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Sgms2
Gene Detail
 Symbol
Name
ID
Sgms2
sphingomyelin synthase 2
MGI:1921692
Synonyms 4933405A16Rik, 5133401H06Rik
Feature Type protein coding gene
Genetic Map
Chromosome 3
60.91 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr3:131318985-131344940 bp, - strand
From VEGA annotation of GRCm38

  25956 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:32705  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Sgms2

Human
homologs
Human Homolog SGMS2, sphingomyelin synthase 2
NCBI Gene ID 166929
neXtProt AC  NX_Q8NHU3
Human Synonyms  SMS2
Human Chr (Location)  4q25; chr4:107824565-107915047 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit increased ceramide levels; decreased sphingomyelin, sphingomyelin-1-phosphate, and diacylglycerol levels; and resistance to lysenin-mediated cytolysis.
 
Phenotype Images(1)
Interactions
Sgms2 interacts with 409 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (19 annotations)
Process lipid metabolic process, phosphorylation, ...
Component Golgi apparatus, integral component of cell outer membrane, ...
Function ceramide cholinephosphotransferase activity, kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (225)    Tissues (114)    Images (32)
Theiler Stages: 13, 22, 23
Assay TypeResults
RNA in situ 225
cDNA source data(30)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(30) cDNA(30)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000022630 (Evidence)
Ensembl Gene ModelENSMUSG00000050931 (Evidence)
Entrez Gene74442 (Evidence)
UniGene273360
DFCITC1605505, TC1704893
DoTSDT.40174947, DT.50316083
NIA Mouse Gene IndexU024659, U256874
EC2.7.8.27
Consensus CDS ProjectCCDS17843.1
International Mouse Knockout Project StatusSgms2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022630 VEGA Gene Model | MGI Sequence Detail 25956 C57BL/6J ±  kb
transcript OTTMUST00000054212 VEGA | MGI Sequence Detail 5801 Not Applicable 
polypeptide OTTMUSP00000025844 VEGA | MGI Sequence Detail 365 Not Applicable 

For the selected sequences
All sequences(40) RefSeq(16) UniProt(2)
Polymorphisms SNPs within 2kb(143 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR025749 Sphingomyelin synthase-like domain
Protein Ontology PR:000014797 phosphatidylcholine:ceramide cholinephosphotransferase 2
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:196477 Wang Z, et al., Transcription factor Ctip2 controls epidermal lipid metabolism and regulates expression of genes involved in sphingolipid biosynthesis during skin development. J Invest Dermatol. 2013 Mar;133(3):668-76
All references(48)
Other
accession IDs
MGI:1918555, MGI:2139836

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/26/2014
MGI 5.19
The Jackson Laboratory